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Matr3 Gene Detail
Summary
  • Symbol
    Matr3
  • Name
    matrin 3
  • Synonyms
    1110061A14Rik, 2810017I02Rik, D030046F20Rik, mKIAA0723
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298379
    NCBI Gene: 17184
  • Gene Overview
    MyGene.info: MATR3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:35562146-35593835 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31690 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 19.14 cM, cytoband C
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    MATR3, matrin 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MATR3, matrin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALS21, MPD2, VCPDM
  • Links
    NCBI Gene ID: 9782
    neXtProt AC: NX_P43243
    UniProt: P43243

  • Chr Location
    5q31.2; chr5:139273752-139331677 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human MATR3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele are early embryonic lethal. Heterozygotes show congenital heart defects including abnormal heart apex morphology, subaortic ventricular septal defects, double-outlet right ventricle, bicuspid aortic valve, aorta coarctation, and patent ductus arteriosus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000045440 VEGA Gene Model | MGI Sequence Detail 31690 C57BL/6J ±  kb
    transcript OTTMUST00000119248 VEGA | MGI Sequence Detail 3107 Not Applicable  
    polypeptide OTTMUSP00000066404 VEGA | MGI Sequence Detail 846 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      73 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      15 Sequences
    • PDB
    • InterPro Domains
      IPR034928 Matrin-3, RNA recognition motif 1
      IPR034930 Matrin-3, RNA recognition motif 2
      IPR000690 Matrin/U1-C, C2H2-type zinc finger
      IPR003604 Matrin/U1-C-like, C2H2-type zinc finger
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR036236 Zinc finger C2H2 superfamily
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 1
      cDNA 27
      Primer pair 4
      Other 1

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGI:1916077, MGI:1917217, MGI:2147265, MGI:2147377, MGI:3026954
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 5
    • Earliest
      J:49740 Matsushima Y, et al., Cloning and genomic mapping of the mouse matrin 3 gene and its pseudogenes. Cytogenet Cell Genet. 1998;81(3-4):194-8
    • Latest
      J:256883 Zhou J, et al., Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system. Biochim Biophys Acta. 2017 Dec;1860(12):1159-1168

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory