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Itgae Gene Detail
Summary
  • Symbol
    Itgae
  • Name
    integrin alpha E, epithelial-associated
  • Synonyms
    alpha-E1, CD103
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298377
    NCBI Gene: 16407
  • Gene Overview
    MyGene.info: ITGAE
Location & Maps
more
  • Sequence Map
    Chr11:73090583-73147446 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      56864 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ITGAE, integrin subunit alpha E
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ITGAE, integrin subunit alpha E
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD103, HUMINAE
  • Links
    NCBI Gene ID: 3682
    neXtProt AC: NX_P38570

  • Chr Location
    17p13; chr17:3714625-3801243 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    41
  • Chemically induced (other)
    1
  • Gene trapped
    33
  • Targeted
    7
  • Genomic Mutations
    2 involving Itgae
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit reductions in the numbers of intestinal and vaginal intraepithelial lymphocytes and of T lymphocytes of the lamina propria.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006122 VEGA Gene Model | MGI Sequence Detail 56864 C57BL/6J ±  kb
transcript OTTMUST00000013843 VEGA | MGI Sequence Detail 3845 Not Applicable  
polypeptide OTTMUSP00000006421 VEGA | MGI Sequence Detail 1167 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    531 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 5
References
more
  • Summaries
    All 70
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 42
  • Earliest
    J:49832 Smith TJ, et al., Murine M290 integrin expression modulated by mast cell activation. Immunity. 1994 Aug;1(5):393-403
  • Latest
    J:227569 Braun A, et al., Integrin alphaE(CD103) Is Involved in Regulatory T-Cell Function in Allergic Contact Hypersensitivity. J Invest Dermatol. 2015 Dec;135(12):2982-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory