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Itgae
Gene Detail
 Symbol
Name
ID
Itgae
integrin alpha E, epithelial-associated
MGI:1298377
Synonyms alpha-E1, CD103
Feature Type protein coding gene
Genetic Map
Chromosome 11
45.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:73090583-73147446 bp, + strand
From VEGA annotation of GRCm38

  56864 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:113560  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: integrin alpha with I domain
Gene Tree: Itgae

Human
homologs
Human Homolog ITGAE, integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
NCBI Gene ID 3682
neXtProt AC  NX_P38570
Human Synonyms  CD103, HUMINAE
Human Chr (Location)  17p13; chr17:3714625-3801243 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(33) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit reductions in the numbers of intestinal and vaginal intraepithelial lymphocytes and of T lymphocytes of the lamina propria.
 
Interactions
Itgae interacts with 137 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cell adhesion, integrin-mediated signaling pathway
Component external side of plasma membrane, integral component of membrane, ...
Function metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (4)    Tissues (4)    Images (1)
Theiler Stages: 23
Assay TypeResults
RNA in situ 4
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(19)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000006122 (Evidence)
Ensembl Gene ModelENSMUSG00000005947 (Evidence)
Entrez Gene16407 (Evidence)
UniGene96
DFCITC1584230, TC1595093, TC1659698
DoTSDT.526758, DT.91410840, DT.94154495
NIA Mouse Gene IndexU043971
Consensus CDS ProjectCCDS24995.1, CCDS24996.1
International Mouse Knockout Project StatusItgae
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006122 VEGA Gene Model | MGI Sequence Detail 56864 C57BL/6J ±  kb
transcript OTTMUST00000013843 VEGA | MGI Sequence Detail 3845 Not Applicable 
polypeptide OTTMUSP00000006421 VEGA | MGI Sequence Detail 1167 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(5)
Polymorphisms SNPs within 2kb(532 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013517 FG-GAP repeat
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000001010 integrin alpha-E
References (Earliest) J:49832 Smith TJ, et al., Murine M290 integrin expression modulated by mast cell activation. Immunity. 1994 Aug;1(5):393-403
(Latest) J:209980 Yamada D, et al., beta7 Integrin controls mast cell recruitment, whereas alphaE integrin modulates the number and function of CD8+ T cells in immune complex-mediated tissue injury. J Immunol. 2014 May 1;192(9):4112-21
All references(70)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory