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Atf1
Gene Detail
Symbol

Name
ID
Atf1
activating transcription factor 1
MGI:1298366
Feature Type
protein coding gene
Genetic Map
Chromosome 15
56.22 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:100227819-100261244 bp, + strand
From VEGA annotation of GRCm38

  33426 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3790  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ATF1
Protein SuperFamily: cAMP response element-binding protein (CREB)
Gene Tree: Atf1

Human
homologs
ATF1, activating transcription factor 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 466
neXtProt AC: NX_P18846

Human Synonyms: EWS-ATF1, FUS/ATF-1, TREB36

Human Chr (Location): 12q13; chr12:50763710-50821167 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(417) : Gene trapped(410) Radiation induced(1) Targeted(6)
Genomic Mutations involving Atf1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene does not result in a phenotype.
 
Phenotype Images(2)
Interactions
Atf1 interacts with 197 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cellular protein complex assembly, positive regulation of DNA replication, ...
Component ATF1-ATF4 transcription factor complex, nucleoplasm, ...
Function DNA binding, protein complex binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (80)    Tissues (76)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 67
Northern blot 2
Western blot 3
RT-PCR 8
cDNA source data(66)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ATF1 ; Xenbase atf1 ; ZFIN atf1    NEW 
Molecular
reagents
All nucleic(67) cDNA(66) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000036768 (Evidence)
Ensembl Gene Model ENSMUSG00000023027 (Evidence)
Entrez Gene 11908 (Evidence)
UniGene 676
DFCI TC1587730, TC1578185
DoTS DT.87072447, DT.94268119, DT.94157094
Consensus CDS Project CCDS27832.1
International Mouse Phenotyping Consortium Status Atf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036768 VEGA Gene Model | MGI Sequence Detail 33426 C57BL/6J ±  kb
transcript OTTMUST00000094349 VEGA | MGI Sequence Detail 2365 Not Applicable 
polypeptide OTTMUSP00000052451 VEGA | MGI Sequence Detail 269 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(6) UniProt(9)
Polymorphisms
SNPs within 2kb(239 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR001630 cAMP response element binding (CREB) protein
InterPro IPR003102 Coactivator CBP, pKID
Protein Ontology PR:000004397 cyclic AMP-dependent transcription factor ATF-1
References
(Earliest) J:49483 Lee MR, et al., Isolation and characterization of nuclear proteins that bind to T cell receptor V beta decamer motif. J Immunol. 1992 Mar 15;148(6):1906-12
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(57)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory