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Atf1 Gene Detail
Summary
  • Symbol
    Atf1
  • Name
    activating transcription factor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298366
    NCBI Gene: 11908
  • Gene Overview
    MyGene.info: ATF1
Location & Maps
more
  • Sequence Map
    Chr15:100227819-100261244 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33426 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 56.22 cM, cytoband F3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ATF1, activating transcription factor 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ATF1, activating transcription factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EWS-ATF1, FUS/ATF-1, TREB36
  • Links
    NCBI Gene ID: 466
    neXtProt AC: NX_P18846

  • Chr Location
    12q13; chr12:50763710-50821167 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    32 phenotypes from multigenic genotypes
    34 phenotype references
  • All Mutations and Alleles
    419
  • Chemically induced (other)
    1
  • Gene trapped
    410
  • Radiation induced
    2
  • Targeted
    6
  • Genomic Mutations
    3 involving Atf1
  • Incidental Mutations
Homozygous mutation of this gene does not result in a phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036768 VEGA Gene Model | MGI Sequence Detail 33426 C57BL/6J ±  kb
transcript OTTMUST00000094349 VEGA | MGI Sequence Detail 2365 Not Applicable  
polypeptide OTTMUSP00000052451 VEGA | MGI Sequence Detail 269 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    237 from dbSNP Build 142
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000004397 cyclic AMP-dependent transcription factor ATF-1
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR029825 cAMP-dependent transcription factor ATF1
    IPR001630 cAMP response element binding (CREB) protein
    IPR003102 Coactivator CBP, pKID
Molecular
Reagents
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  • All nucleic 67
    cDNA 66
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 56
    Developmental Gene Expression 16
    Diseases 1
    Gene Ontology 7
    Phenotypes 34
  • Earliest
    J:49483 Lee MR, et al., Isolation and characterization of nuclear proteins that bind to T cell receptor V beta decamer motif. J Immunol. 1992 Mar 15;148(6):1906-12
  • Latest
    J:224317 Takii R, et al., ATF1 modulates the heat shock response by regulating the stress-inducible heat shock factor 1 transcription complex. Mol Cell Biol. 2015 Jan;35(1):11-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory