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Atf1
Gene Detail
 Symbol
Name
ID
Atf1
activating transcription factor 1
MGI:1298366
Feature Type protein coding gene
Genetic Map
Chromosome 15
56.22 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:100227819-100261244 bp, + strand
From VEGA annotation of GRCm38

  33426 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3790  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cAMP response element-binding protein (CREB)
Gene Tree: Atf1

Human
homologs
Human Homolog ATF1, activating transcription factor 1
NCBI Gene ID 466
neXtProt AC  NX_P18846
Human Synonyms  EWS-ATF1, FUS/ATF-1, TREB36
Human Chr (Location)  12q13; chr12:50764006-50821160 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(415) : Gene trapped(410) Radiation induced(1) Targeted(4)
Genomic Mutations involving Atf1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene does not result in a phenotype.
 
Interactions
Atf1 interacts with 197 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cellular protein complex assembly, positive regulation of DNA replication, ...
Component nucleus, transcription factor complex
Function DNA binding, protein complex binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (84)    Tissues (78)    Images (10)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 19, 20, 21, 22, 23, 28
Assay TypeResults
RNA in situ 67
Northern blot 2
RT-PCR 15
cDNA source data(66)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(67) cDNA(66) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036768 (Evidence)
Ensembl Gene ModelENSMUSG00000023027 (Evidence)
Entrez Gene11908 (Evidence)
UniGene676
DFCITC1578185, TC1587730
DoTSDT.87072447, DT.94157094, DT.94268119
Consensus CDS ProjectCCDS27832.1
International Mouse Knockout Project StatusAtf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036768 VEGA Gene Model | MGI Sequence Detail 33426 C57BL/6J ±  kb
transcript OTTMUST00000094349 VEGA | MGI Sequence Detail 2365 Not Applicable 
polypeptide OTTMUSP00000052451 VEGA | MGI Sequence Detail 269 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(6) UniProt(9)
Polymorphisms SNPs within 2kb(239 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR001630 cAMP response element binding (CREB) protein
InterPro IPR003102 Coactivator CBP, pKID
Protein Ontology PR:000004397 cyclic AMP-dependent transcription factor ATF-1
References (Earliest) J:49483 Lee MR, et al., Isolation and characterization of nuclear proteins that bind to T cell receptor V beta decamer motif. J Immunol. 1992 Mar 15;148(6):1906-12
(Latest) J:191723 Mackenzie KF, et al., PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A-SIK-CRTC3 Pathway. J Immunol. 2013 Jan 15;190(2):565-77
All references(56)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory