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Kcnk4 Gene Detail
Summary
  • Symbol
    Kcnk4
  • Name
    potassium channel, subfamily K, member 4
  • Synonyms
    TRAAKt
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298234
    NCBI Gene: 16528
  • Gene Overview
    MyGene.info: KCNK4
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6925710-6934515 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298234
protein coding gene Chr19:6924866-6934772 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024772
protein coding gene Chr19:4015235-4026523 (-)
A/J MGP_AJ_G0024738
protein coding gene Chr19:3686989-3696811 (-)
AKR/J MGP_AKRJ_G0024711
protein coding gene Chr19:3802473-3814822 (-)
BALB/cJ MGP_BALBcJ_G0024738
protein coding gene Chr19:3796272-3804999 (-)
C3H/HeJ MGP_C3HHeJ_G0024506
protein coding gene Chr19:3929297-3938964 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025184
protein coding gene Chr19:4107135-4118914 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022618
protein coding gene Chr19:3596138-3604466 (-)
CAST/EiJ MGP_CASTEiJ_G0023977
protein coding gene Chr19:3835862-3847306 (-)
CBA/J MGP_CBAJ_G0024478
protein coding gene Chr19:4156481-4168653 (-)
DBA/2J MGP_DBA2J_G0024605
protein coding gene Chr19:3660615-3669187 (-)
FVB/NJ MGP_FVBNJ_G0024571
protein coding gene Chr19:3689075-3696578 (-)
LP/J MGP_LPJ_G0024691
protein coding gene Chr19:3877970-3886333 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024600
protein coding gene Chr19:4061224-4070238 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025232
protein coding gene Chr19:3937223-3946010 (-)
PWK/PhJ MGP_PWKPhJ_G0023723
protein coding gene Chr19:3700554-3712161 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023529
protein coding gene Chr19:3759681-3772399 (-)
WSB/EiJ MGP_WSBEiJ_G0024040
protein coding gene Chr19:3839651-3850227 (-)



Homology
more
  • Human Ortholog
    KCNK4, potassium two pore domain channel subfamily K member 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KCNK4, potassium two pore domain channel subfamily K member 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    K2p4.1, TRAAK, TRAAK1
  • Links
    NCBI Gene ID: 50801
    neXtProt AC: NX_Q9NYG8
    UniProt: Q9NYG8

  • Chr Location
    11q13.1; chr11:64291302-64300031 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    10 phenotype references
Mice homozygous for a null allele exhibit normal sensitivity to pharmacologically induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024957 Ensembl Gene Model | MGI Sequence Detail 8806 C57BL/6J ±  kb
transcript ENSMUST00000025908 Ensembl | MGI Sequence Detail 1715 Not Applicable  
polypeptide ENSMUSP00000025908 Ensembl | MGI Sequence Detail 398 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 2
    cDNA 7
    Primer pair 5

    Microarray probesets 4
References
more
  • Summaries
    All 38
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:48292 Fink M, et al., A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids. EMBO J. 1998 Jun 15;17(12):3297-308
  • Latest
    J:251470 Schwingshackl A, et al., Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1030-L1046

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory