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Kcnk4
Gene Detail
 Symbol
Name
ID
Kcnk4
potassium channel, subfamily K, member 4
MGI:1298234
Synonyms TRAAKt
Feature Type protein coding gene
Genetic Map
Chromosome 19
5.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:6925710-6934515 bp, - strand
From Ensembl annotation of GRCm38

  8806 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7391  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Kcnk4

Human
homologs
Human Homolog KCNK4, potassium channel, subfamily K, member 4
NCBI Gene ID 50801
neXtProt AC  NX_Q9NYG8
Human Synonyms  K2p4.1, TRAAK, TRAAK1
Human Chr (Location)  11q13; chr11:64291321-64300031 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(4) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit normal sensitivity to pharmacologically induced seizures.
 
Interactions
Kcnk4 interacts with 46 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component integral component of membrane, membrane
Function potassium channel activity, voltage-gated ion channel activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (16)    Tissues (9)   
Theiler Stages: 2, 3, 4, 25, 28
Assay TypeResults
Immunohistochemistry 3
RT-PCR 13
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(7) Primer pair(5)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000024957 (Evidence)
Entrez Gene16528 (Evidence)
UniGene12894
DFCITC1590517
DoTSDT.91333164
Consensus CDS ProjectCCDS29511.1
International Mouse Knockout Project StatusKcnk4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024957 Ensembl Gene Model | MGI Sequence Detail 8806 C57BL/6J ±  kb
transcript ENSMUST00000025908 Ensembl | MGI Sequence Detail 1715 Not Applicable 
polypeptide ENSMUSP00000025908 Ensembl | MGI Sequence Detail 398 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(14) UniProt(2)
Polymorphisms SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013099 Ion transport 2
InterPro IPR003280 Two pore domain potassium channel
InterPro IPR008074 Two pore domain potassium channel, TRAAK
Protein Ontology PR:000009265 potassium channel subfamily K member 4
References (Earliest) J:48292 Fink M, et al., A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids. EMBO J. 1998 Jun 15;17(12):3297-308
(Latest) J:197938 Hao J, et al., Kv1.1 channels act as mechanical brake in the senses of touch and pain. Neuron. 2013 Mar 6;77(5):899-914
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory