About   Help   FAQ
Kcnk4 Gene Detail
Summary
  • Symbol
    Kcnk4
  • Name
    potassium channel, subfamily K, member 4
  • Synonyms
    TRAAKt
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298234
    NCBI Gene: 16528
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6903030-6912261 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    224 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298234
 protein coding gene Chr19:6901334-6912261 (-)
129S1/SvImJ ENSMUSG00200051884
 protein coding gene Chr19:3627248-3638022 (-)
A/J ENSMUSG00195049972
 protein coding gene Chr19:4029161-4039936 (-)
AKR/J ENSMUSG00220046354
 protein coding gene Chr19:3798597-3809369 (-)
BALB/cJ ENSMUSG00180045712
 protein coding gene Chr19:4392733-4403506 (-)
C3H/HeJ ENSMUSG00175011785
 protein coding gene Chr19:3649172-3659949 (-)
C57BL/6NJ ENSMUSG00215041074
 protein coding gene Chr19:3867670-3878448 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022618
 protein coding gene Chr19:3596138-3604466 (-)
CAST/EiJ ENSTCUG00005028882
 protein coding gene Chr19:3770637-3781418 (-)
CBA/J ENSMUSG00210049450
 protein coding gene Chr19:3653455-3663338 (-)
DBA/2J ENSMUSG00185047463
 protein coding gene Chr19:4029007-4039813 (-)
FVB/NJ ENSMUSG00205030339
 protein coding gene Chr19:4028142-4038902 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230053675
 protein coding gene Chr19:4953980-4964753 (-)
NOD/ShiLtJ ENSMUSG00190046921
 protein coding gene Chr19:3560447-3571222 (-)
NZO/HlLtJ ENSMUSG00225026604
 protein coding gene Chr19:8662799-8673573 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010050152
 protein coding gene Chr19:3745987-3756666 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    KCNK4, potassium two pore domain channel subfamily K member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNK4, potassium two pore domain channel subfamily K member 4
  • Synonyms
    FHEIG, K2p4.1, TRAAK, TRAAK1
  • Links
    NCBI Gene ID: 50801
    UniProt: Q9NYG8

  • Chr Location
    11q13.1; chr11:64291302-64300031 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    15 phenotype references
Mice homozygous for a null allele exhibit normal sensitivity to pharmacologically induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    618
  • Tissues
    15
  • cDNA Data
    7
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16528 NCBI Gene Model | MGI Sequence Detail 9232 C57BL/6J ±  kb
transcript NM_001403916 RefSeq | MGI Sequence Detail 2060 C57BL/6  
polypeptide O88454 UniProt | EBI | MGI Sequence Detail 398 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 2
    cDNA 7
    Primer pair 6
    Other 1
    Antibodies 1

    Microarray probesets 4
References
more
  • Summaries
    All 49
    Developmental Gene Expression 4
    Gene Ontology 10
    Phenotypes 15
  • Earliest
    J:48292 Fink M, et al., A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids. EMBO J. 1998 Jun 15;17(12):3297-308
  • Latest
    J:324668 Glogowska E, et al., Piezo1 and Piezo2 foster mechanical gating of K2P channels. Cell Rep. 2021 Nov 30;37(9):110070
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory