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Tpst1 Gene Detail
Summary
  • Symbol
    Tpst1
  • Name
    protein-tyrosine sulfotransferase 1
  • Synonyms
    Tango13a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298231
    NCBI Gene: 22021
Location & Maps
more
  • Sequence Map
    Chr5:130073326-130135729 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      62404 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 68.53 cM, cytoband F-G1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TPST1, tyrosylprotein sulfotransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TPST1, tyrosylprotein sulfotransferase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TANGO13A
  • Links
    NCBI Gene ID: 8460
    neXtProt AC: NX_O60507

  • Chr Location
    7q11.21; chr7:66205272-66360451 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2667
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TPST1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    22
  • Chemically induced (other)
    1
  • Gene trapped
    15
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Tpst1
  • Incidental Mutations
Homozygous null mice exhibit reduced body weight but develop normally. Homozygous females produce smaller sized litters than control females.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027866 VEGA Gene Model | MGI Sequence Detail 62404 C57BL/6J ±  kb
transcript OTTMUST00000069018 VEGA | MGI Sequence Detail 1867 Not Applicable  
polypeptide OTTMUSP00000035003 VEGA | MGI Sequence Detail 370 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    252 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016594 protein-tyrosine sulfotransferase 1
  • EC
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR026634 Protein-tyrosine sulfotransferase
Molecular
Reagents
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  • All nucleic 66
    Genomic 1
    cDNA 65

    Microarray probesets 3
Other
Accession IDs
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MGI:2141351
References
more
  • Summaries
    All 35
    Gene Ontology 3
    Phenotypes 20
  • Earliest
    J:48787 Ouyang YB, et al., Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2896-901
  • Latest
    J:205883 Westmuckett AD, et al., Salivary gland hypofunction in tyrosylprotein sulfotransferase-2 knockout mice is due to primary hypothyroidism. PLoS One. 2013;8(8):e71822

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory