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Tpst1
Gene Detail
 Symbol
Name
ID
Tpst1
protein-tyrosine sulfotransferase 1
MGI:1298231
Synonyms Tango13a
Feature Type protein coding gene
Genetic Map
Chromosome 5
68.53 cM, cytoband F-G1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:130073326-130135729 bp, + strand
From VEGA annotation of GRCm38

  62404 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2667  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tpst1

Human
homologs
Human Homolog TPST1, tyrosylprotein sulfotransferase 1
NCBI Gene ID 8460
neXtProt AC  NX_O60507
Human Synonyms  TANGO13A
Human Chr (Location)  7q11.21; chr7:66205272-66360451 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(15) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit reduced body weight but develop normally. Homozygous females produce smaller sized litters than control females.
 
Interactions
Tpst1 interacts with 90 markers (Mir18, Mir18b, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process peptidyl-tyrosine sulfation
Component Golgi apparatus, integral component of membrane, ...
Function protein-tyrosine sulfotransferase activity, transferase activity
External Resources: FuncBase
Expression
cDNA source data(65)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(66) Genomic(1) cDNA(65)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000027866 (Evidence)
Ensembl Gene ModelENSMUSG00000034118 (Evidence)
Entrez Gene22021 (Evidence)
UniGene332720
DFCITC1578130, TC1652242
DoTSDT.55241741, DT.97411852
NIA Mouse Gene IndexU006241
EC2.8.2.20
Consensus CDS ProjectCCDS39293.1
International Mouse Knockout Project StatusTpst1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027866 VEGA Gene Model | MGI Sequence Detail 62404 C57BL/6J ±  kb
transcript OTTMUST00000069018 VEGA | MGI Sequence Detail 1867 Not Applicable 
polypeptide OTTMUSP00000035003 VEGA | MGI Sequence Detail 370 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(252 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR026634 Protein-tyrosine sulfotransferase
Protein Ontology PR:000016594 protein-tyrosine sulfotransferase 1
References (Earliest) J:48787 Ouyang YB, et al., Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2896-901
(Latest) J:205883 Westmuckett AD, et al., Salivary gland hypofunction in tyrosylprotein sulfotransferase-2 knockout mice is due to primary hypothyroidism. PLoS One. 2013;8(8):e71822
All references(37)
Other
accession IDs
MGI:2141351

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory