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Cnot7 Gene Detail
Summary
  • Symbol
    Cnot7
  • Name
    CCR4-NOT transcription complex, subunit 7
  • Synonyms
    Caf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298230
    NCBI Gene: 18983
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:40945581-40968888 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 23.89 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    174 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298230
 protein coding gene Chr8:40945579-40968888 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033553
 protein coding gene Chr8:39295222-39318371 (-)
A/J MGP_AJ_G0033533
 protein coding gene Chr8:37796895-37820539 (-)
AKR/J MGP_AKRJ_G0033457
 protein coding gene Chr8:38915161-38938278 (-)
BALB/cJ MGP_BALBcJ_G0033529
 protein coding gene Chr8:37886754-37909885 (-)
C3H/HeJ MGP_C3HHeJ_G0033241
 protein coding gene Chr8:39307580-39331559 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034045
 protein coding gene Chr8:40819563-40844438 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030994
 protein coding gene Chr8:34427875-34465393 (-)
CAST/EiJ MGP_CASTEiJ_G0032569
 protein coding gene Chr8:38830993-38859890 (-)
CBA/J MGP_CBAJ_G0033219
 protein coding gene Chr8:42480885-42504015 (-)
DBA/2J MGP_DBA2J_G0033372
 protein coding gene Chr8:37649065-37672733 (-)
FVB/NJ MGP_FVBNJ_G0033317
 protein coding gene Chr8:37226514-37249791 (-)
LP/J MGP_LPJ_G0033462
 protein coding gene Chr8:39315689-39340149 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033359
 protein coding gene Chr8:42263426-42290051 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034064
 protein coding gene Chr8:39116293-39140425 (-)
PWK/PhJ MGP_PWKPhJ_G0032278
 protein coding gene Chr8:37194474-37218107 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032110
 protein coding gene Chr8:38318473-38341796 (-)
WSB/EiJ MGP_WSBEiJ_G0032684
 protein coding gene Chr8:39311612-39336309 (-)



Homology
more
  • Human Ortholog
    CNOT7, CCR4-NOT transcription complex subunit 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNOT7, CCR4-NOT transcription complex subunit 7
  • Synonyms
    CAF1, CAF-1, Caf1a, hCAF-1
  • Links
    NCBI Gene ID: 29883
    neXtProt AC: NX_Q9UIV1
    UniProt: Q9UIV1

  • Chr Location
    8p22; chr8:17224966-17246878 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display male sterility with oligo-teratozoospermia, impaired sperm motility, unsynchronized spermatid maturation, and Sertoli cell abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    870
  • Tissues
    75
  • cDNA Data
    119
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031601 Ensembl Gene Model | MGI Sequence Detail 23308 C57BL/6J ±  kb
    transcript ENSMUST00000034012 Ensembl | MGI Sequence Detail 2615 Not Applicable  
    polypeptide ENSMUSP00000034012 Ensembl | MGI Sequence Detail 285 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 121
      cDNA 120
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2142708
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 18
      Gene Ontology 18
      Phenotypes 14
    • Earliest
      J:26204 Draper MP, et al., Identification of a mouse protein whose homolog in Saccharomyces cerevisiae is a component of the CCR4 transcriptional regulatory complex. Mol Cell Biol. 1995 Jul;15(7):3487-95
    • Latest
      J:343009 Soeda S, et al., The CCR4-NOT complex suppresses untimely translational activation of maternal mRNAs. Development. 2023 Nov 1;150(21):dev201773
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory