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Nid2
Gene Detail
Symbol

Name
ID
Nid2
nidogen 2
MGI:1298229
Synonyms
entactin 2, entactin-2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
10.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:19751257-19811787 bp, + strand
From NCBI annotation of GRCm38

  60531 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40575  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nid2

Human
homologs
Human Homolog NID2, nidogen 2 (osteonidogen)
NCBI Gene ID 22795
neXtProt AC  NX_Q14112
Human Synonyms  NID-2
Human Chr (Location)  14q22.1; chr14:52004802-52069228 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(25) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele appear healthy and fertile with no gross anatomical abnormalities.
 
Interactions
Nid2 interacts with 159 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell adhesion, cell-matrix adhesion
Component basement membrane, cell surface, ...
Function calcium ion binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (110)    Tissues (88)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 21
RNA in situ 89
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(15) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000021806 (Evidence)
Entrez Gene18074 (Evidence)
DFCITC1595556, TC1572473
NIA Mouse Gene IndexU015355
Consensus CDS ProjectCCDS36813.1
International Mouse Knockout Project StatusNid2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18074 NCBI Gene Model | MGI Sequence Detail 60531 C57BL/6J ±  kb
transcript NM_008695 RefSeq | MGI Sequence Detail 4913 C57BL/6 
polypeptide O88322 UniProt | EBI | MGI Sequence Detail 1403 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(11)
Polymorphisms
SNPs within 2kb(542 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026823 Complement Clr-like EGF domain
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR006605 G2 nidogen/fibulin G2F
InterPro IPR009017 Green fluorescent protein
InterPro IPR023413 Green fluorescent protein-like
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000033 LDLR class B repeat
InterPro IPR003886 Nidogen, extracellular domain
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
InterPro IPR000716 Thyroglobulin type-1
Protein Ontology PR:000011209 nidogen-2
Graphical View of Protein Domain Structure
References
(Earliest) J:48072 Kimura N, et al., Entactin-2: a new member of basement membrane protein with high homology to entactin/ nidogen. Exp Cell Res. 1998 May 25;241(1):36-45
(Latest) J:213088 Soteriou D, et al., Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. J Biol Chem. 2013 Jun 28;288(26):18716-31
All references(62)
Other
accession IDs
MGI:2145830

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory