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Nid2 Gene Detail
Summary
  • Symbol
    Nid2
  • Name
    nidogen 2
  • Synonyms
    entactin 2, entactin-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298229
    NCBI Gene: 18074
  • Gene Overview
    MyGene.info: NID2
Location & Maps
more
  • Sequence Map
    Chr14:19751257-19811787 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      60531 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 10.73 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NID2, nidogen 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NID2, nidogen 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NID-2
  • Links
    NCBI Gene ID: 22795
    neXtProt AC: NX_Q14112

  • Chr Location
    14q22.1; chr14:52004802-52069231 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 40575
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NID2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null alleleexhibit calcification of joint cartilage and osteoarthritis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18074 NCBI Gene Model | MGI Sequence Detail 60531 C57BL/6J ±  kb
transcript NM_008695 RefSeq | MGI Sequence Detail 4913 C57BL/6  
polypeptide O88322 UniProt | EBI | MGI Sequence Detail 1403 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    539 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 16
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2145830
References
more
  • Summaries
    All 61
    Developmental Gene Expression 23
    Gene Ontology 9
    Phenotypes 17
  • Earliest
    J:48072 Kimura N, et al., Entactin-2: a new member of basement membrane protein with high homology to entactin/ nidogen. Exp Cell Res. 1998 May 25;241(1):36-45
  • Latest
    J:229684 Schminke B, et al., Laminins and Nidogens in the Pericellular Matrix of Chondrocytes: Their Role in Osteoarthritis and Chondrogenic Differentiation. Am J Pathol. 2016 Feb;186(2):410-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory