About   Help   FAQ
Mcm6
Gene Detail
Symbol

Name
ID
Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
MGI:1298227
Synonyms
D1Wsu22e, Mcmd6
Feature Type
protein coding gene
Genetic Map
Chromosome 1
55.80 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:128331590-128359664 bp, - strand
From VEGA annotation of GRCm38

  28075 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4322  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: DNA replication licensing factor MCM6
Gene Tree: Mcm6

Human
homologs
Human Homolog MCM6, minichromosome maintenance complex component 6
NCBI Gene ID 4175
neXtProt AC  NX_Q14566
Human Synonyms  MCG40308, Mis5, P105MCM
Human Chr (Location)  2q21; chr2:135839626-135876477 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MCM6
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(11)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit increased micronulei-containing red blood cells.
 
Interactions
Mcm6 interacts with 69 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell cycle, DNA replication, ...
Component MCM complex, nucleus
Function ATP binding, ATP-dependent DNA helicase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (52)    Tissues (37)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 27
RNA in situ 19
RT-PCR 6
cDNA source data(227)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(230) Genomic(1) cDNA(228) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000049360 (Evidence)
Ensembl Gene ModelENSMUSG00000026355 (Evidence)
Entrez Gene17219 (Evidence)
UniGene4933
DFCITC1573175
DoTSDT.101245609, DT.102558986, DT.110902923, DT.495748, DT.94307037, DT.94408867
NIA Mouse Gene IndexU021731
EC3.6.4.12
Consensus CDS ProjectCCDS15252.1
International Mouse Knockout Project StatusMcm6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049360 VEGA Gene Model | MGI Sequence Detail 28075 C57BL/6J ±  kb
transcript OTTMUST00000125829 VEGA | MGI Sequence Detail 2910 Not Applicable 
polypeptide OTTMUSP00000068109 VEGA | MGI Sequence Detail 821 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(406 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008049 DNA replication licensing factor Mcm6
InterPro IPR018525 Mini-chromosome maintenance, conserved site
InterPro IPR001208 Mini-chromosome maintenance, DNA-dependent ATPase
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR004039 Rubredoxin-type fold
Protein Ontology PR:000010248 DNA replication licensing factor MCM6
References
(Earliest) J:49048 Kimura H, et al., Mouse MCM proteins: complex formation and transportation to the nucleus. Genes Cells. 1996 Nov;1(11):977-93
(Latest) J:197897 Mi D, et al., Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb. Neuron. 2013 Apr 24;78(2):269-84
All references(53)
Other
accession IDs
MGD-MRK-34267, MGI:106573

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/21/2014
MGI 5.20
The Jackson Laboratory