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Mcm6 Gene Detail
Summary
  • Symbol
    Mcm6
  • Name
    minichromosome maintenance complex component 6
  • Synonyms
    D1Wsu22e, Mcmd6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298227
    NCBI Gene: 17219
  • Gene Overview
    MyGene.info: MCM6
Location & Maps
more
  • Sequence Map
    Chr1:128331590-128359664 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28075 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MCM6, minichromosome maintenance complex component 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MCM6, minichromosome maintenance complex component 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MCG40308, Mis5, P105MCM
  • Links
    NCBI Gene ID: 4175
    neXtProt AC: NX_Q14566

  • Chr Location
    2q21; chr2:135839626-135876477 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MCM6 associations

Human Disease Mouse Models
       Lactose Intolerance, Adult Type   OMIM: 223100
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    2
  • Gene trapped
    11
  • Radiation induced
    1
  • Genomic Mutations
    3 involving Mcm6
  • Incidental Mutations
Mice homozygous for a gene trapped allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit increased micronulei-containing red blood cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049360 VEGA Gene Model | MGI Sequence Detail 28075 C57BL/6J ±  kb
transcript OTTMUST00000125829 VEGA | MGI Sequence Detail 2910 Not Applicable  
polypeptide OTTMUSP00000068109 VEGA | MGI Sequence Detail 821 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    404 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 230
    Genomic 1
    cDNA 228
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-34267, MGI:106573
References
more
  • Summaries
    All 49
    Developmental Gene Expression 9
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:49048 Kimura H, et al., Mouse MCM proteins: complex formation and transportation to the nucleus. Genes Cells. 1996 Nov;1(11):977-93
  • Latest
    J:222249 Tu HC, et al., LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans. Genes Dev. 2015 May 15;29(10):1074-86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory