Mcm6
Gene Detail

Symbol Name ID

Mcm6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) MGI:1298227

Synonyms

D1Wsu22e, Mcmd6

Feature Type

protein coding gene

Genetic Map

Chromosome 1

55.80 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:128331591-128359656 bp, - strand From NCBI annotation of GRCm38   28066 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4322  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DNA replication licensing factor MCM6
Gene Tree: Mcm6

Human homologs

Human Homolog		MCM6, minichromosome maintenance complex component 6
NCBI Gene ID		4175
neXtProt AC		NX_Q14566
Human Synonyms		MCG40308, Mis5, P105MCM
Human Chr (Location)		2q21; chr2:136597196-136634047 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MCM6

Alleles and phenotypes

All alleles(11) : Gene trapped(11)
 

Mice homozygous for a gene trapped allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit increased micronulei-containing red blood cells.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	cell cycle, DNA replication, ...
Component	MCM complex, nucleus
Function	ATP binding, ATP-dependent DNA helicase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (52)    Tissues (36)    Images (32)
Theiler Stages: 11, 15, 17, 19, 21, 24, 28

Assay Type	Results
Immunohistochemistry	27
RNA in situ	19
RT-PCR	6

cDNA source data(226)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(229) Genomic(1) cDNA(227) Primer pair(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000026355 (Evidence)
Entrez Gene	17219 (Evidence)
UniGene	4933
DFCI	TC1573175
DoTS	DT.101245609, DT.102558986, DT.110902923, DT.495748, DT.94307037, DT.94408867
NIA Mouse Gene Index	U021731
EC	3.6.4.12
Consensus CDS Project	CCDS15252.1
International Mouse Knockout Project Status	Mcm6

Sequences

Length	Strain/Species
genomic	17219	NCBI Gene Model | MGI Sequence Detail	28066	C57BL/6J
transcript	NM_008567	RefSeq | MGI Sequence Detail	2901	Not Specified
polypeptide	P97311	UniProt | EBI | MGI Sequence Detail	821	Not Applicable

All sequences(61) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(138 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008049	Mini-chromosome maintenance complex protein 6
InterPro	IPR018525	Mini-chromosome maintenance, conserved site
InterPro	IPR001208	Mini-chromosome maintenance, DNA-dependent ATPase
InterPro	IPR012340	Nucleic acid-binding, OB-fold
InterPro	IPR016027	Nucleic acid-binding, OB-fold-like
Protein Ontology	PR:000010248	DNA replication licensing factor MCM6

Graphical View of Protein Domain Structure

References

(Earliest) J:49048 Kimura H, et al., Mouse MCM proteins: complex formation and transportation to the nucleus. Genes Cells. 1996 Nov;1(11):977-93
(Latest) J:187391 Pacal M, et al., Mapping differentiation kinetics in the mouse retina reveals an extensive period of cell cycle protein expression in post-mitotic newborn neurons. Dev Dyn. 2012 Oct;241(10):1525-44
All references(51)

Other accession IDs

MGD-MRK-34267, MGI:106573