About   Help   FAQ
Pip5k1c
Gene Detail
Symbol

Name
ID
Pip5k1c
phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
MGI:1298224
Synonyms
mKIAA0589, PIP5KIgamma
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:81292963-81319973 bp, + strand
From VEGA annotation of GRCm38

  27011 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69032  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Pip5k1c

Human
homologs
Human Homolog PIP5K1C, phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
NCBI Gene ID 23396
neXtProt AC  NX_O60331
Human Synonyms  LCCS3, PIP5K1-gamma, PIP5Kgamma, PIP5K-GAMMA
Human Chr (Location)  19p13.3; chr19:3630181-3700486 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PIP5K1C
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(5) Targeted(9)
Incidental mutations (data from APF )
 
Mutations in this locus cause variable phenotypes. One allele shows embryonic lethality, abnormal cardiovascular and neuronal development and impaired integrity of the megakaryocyte membrane cytoskeleton. Another allele exhibits neonatal lethality, synaptic transmission and plasticity defects.
 
Phenotype Images(5)
Interactions
Pip5k1c interacts with 356 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process axonogenesis, cell adhesion, ...
Component cell, cell junction, ...
Function 1-phosphatidylinositol-4-phosphate 5-kinase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (292)    Tissues (152)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 291
Northern blot 1
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(14) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000033475 (Evidence)
Ensembl Gene ModelENSMUSG00000034902 (Evidence)
Entrez Gene18717 (Evidence)
DFCITC1572536, TC1724005, TC1588828
DoTSDT.101398631, DT.101238306, DT.50316779, DT.101398633, DT.94306331
NIA Mouse Gene IndexU011778
EC2.7.1.68
PDB2H7D, 2H7E, 1Y19
Consensus CDS ProjectCCDS35994.1, CCDS48643.1
International Mouse Knockout Project StatusPip5k1c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033475 VEGA Gene Model | MGI Sequence Detail 27011 C57BL/6J ±  kb
transcript OTTMUST00000084129 VEGA | MGI Sequence Detail 4323 Not Applicable 
polypeptide OTTMUSP00000045293 VEGA | MGI Sequence Detail 687 Not Applicable 

For the selected sequences
All sequences(106) RefSeq(10) UniProt(13)
Polymorphisms
SNPs within 2kb(70 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023610 Phosphatidylinositol-4-phosphate 5-kinase
InterPro IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
InterPro IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
InterPro IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
InterPro IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
Protein Ontology PR:000012746 phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
References
(Earliest) J:46962 Ishihara H, et al., Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/ substitution analysis of members of this novel lipid kinase family. J Biol Chem. 1998 Apr 10;273(15):8741-8
(Latest) J:214303 Wright BD, et al., The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron. 2014 May 21;82(4):836-47
All references(63)
Other
accession IDs
MGI:2143524, MGI:2143672

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory