Naip1
Gene Detail

Symbol Name ID

Naip1 NLR family, apoptosis inhibitory protein 1 MGI:1298223

Synonyms

Birc1a, D13Lsd1, Naip

Feature Type

protein coding gene

Genetic Map

Chromosome 13

53.18 cM, cytoband D1-D3
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr13:100407770-100446406 bp, - strand From Ensembl annotation of GRCm38   38637 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human    (Mammalian Orthology)
Comparative Map (Mouse/Human Naip1 ± 2 cM)

Protein SuperFamily: neuronal apoptosis inhibitory protein
Gene Tree: Naip1

Human ortholog

NAIP NLR family, apoptosis inhibitory protein NCBI Gene ID 4671
Human Synonyms: BIRC1, NLRB1, psiNAIP
Human Chr5:70264310-70320941 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous for disruptions in this gene display a normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	apoptotic process, cellular response to estrogen stimulus, ...
Component	basolateral plasma membrane, cytoplasm, ...
Function	ATP binding, cysteine-type endopeptidase inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (122)    Tissues (67)    Images (3)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	24
In situ reporter (knock in)	48
RT-PCR	50

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(36) Genomic(20) cDNA(9) Primer pair(6) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000021640 (Evidence)
Entrez Gene	17940 (Evidence)
UniGene	6898
DoTS	DT.485607, DT.91335568
NIA Mouse Gene Index	U035107
Consensus CDS Project	CCDS26729.1
International Mouse Knockout Project Status	Naip1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000021640	Ensembl Gene Model | MGI Sequence Detail	38637	C57BL/6J
transcript	ENSMUST00000022142	Ensembl | MGI Sequence Detail	5353	Not Applicable
polypeptide	ENSMUSP00000022142	Ensembl | MGI Sequence Detail	1403	Not Applicable

All sequences(22) RefSeq(2) UniProt(2)

Polymorphisms

PCR(3) : SNPs(281 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR001370	Baculoviral inhibition of apoptosis protein repeat
InterPro	IPR007111	NACHT nucleoside triphosphatase
Protein Ontology	PR:000011552	baculoviral IAP repeat-containing protein 1a

References

(Earliest) J:37707 Scharf JM, et al., The mouse region syntenic for human spinal muscular atrophy lies within the Lgn1 critical interval and contains multiple copies of Naip exon 5. Genomics. 1996 Dec 15;38(3):405-17
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(48)

Other accession IDs

MGD-MRK-38374, MGD-MRK-39477, MGI:109329, MGI:109478, MGI:2145401