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Naip1 Gene Detail
Summary
  • Symbol
    Naip1
  • Name
    NLR family, apoptosis inhibitory protein 1
  • Synonyms
    Birc1a, D13Lsd1, Naip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298223
    NCBI Gene: 17940
  • Member of
    Naipc cluster
  • Gene Overview
    MyGene.info: NAIP
Location & Maps
more
  • Sequence Map
    Chr13:100407770-100446406 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      38637 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 53.18 cM, cytoband D1-D3
  • Mapping Data
    13 experiments
Homology
more
  • Human Ortholog
    NAIP, NLR family apoptosis inhibitory protein
  • Vertebrate Orthologs
    5
  • Human Ortholog
    NAIP, NLR family apoptosis inhibitory protein
    Orthology source: HGNC
  • Synonyms
    BIRC1, NLRB1, psiNAIP
  • Links
    NCBI Gene ID: 4671
    neXtProt AC: NX_Q13075

  • Chr Location
    5q13.2; chr5:70968483-71025114 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Targeted
    7
  • Genomic Mutations
    1 involving Naip1
  • Incidental Mutations
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021640 Ensembl Gene Model | MGI Sequence Detail 38637 C57BL/6J ±  kb
transcript ENSMUST00000022142 Ensembl | MGI Sequence Detail 5353 Not Applicable  
polypeptide ENSMUSP00000022142 Ensembl | MGI Sequence Detail 1403 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    321 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000011552 baculoviral IAP repeat-containing protein 1a
  • InterPro Domains
    IPR001370 BIR repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR007111 NACHT nucleoside triphosphatase
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 36
    Genomic 20
    cDNA 9
    Primer pair 6
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-38374, MGD-MRK-39477, MGI:109329, MGI:109478, MGI:2145401
References
more
  • Summaries
    All 49
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:37707 Scharf JM, et al., The mouse region syntenic for human spinal muscular atrophy lies within the Lgn1 critical interval and contains multiple copies of Naip exon 5. Genomics. 1996 Dec 15;38(3):405-17
  • Latest
    J:233320 Rauch I, et al., NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. J Exp Med. 2016 May 2;213(5):657-65

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory