Naip6
Gene Detail

Symbol Name ID

Naip6 NLR family, apoptosis inhibitory protein 6 MGI:1298222

Synonyms

Birc1f, Naip-rs4, Naip-rs4A

Feature Type

protein coding gene

Genetic Map

Chromosome 13

53.09 cM, cytoband D1-D3
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr13:100281121-100317674 bp, - strand From VEGA annotation of GRCm38   36554 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:113589  Vertebrate Homology Class
1 human; 3 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Protein SuperFamily: neuronal apoptosis inhibitory protein
Gene Tree: Naip6

Human homologs

Human Homolog		NAIP, NLR family, apoptosis inhibitory protein
NCBI Gene ID		4671
neXtProt AC		NX_Q13075
Human Synonyms		BIRC1, NLRB1, psiNAIP
Human Chr (Location)		5q13.2; chr5:70264310-70320941 (-)  GRCh37.p10

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	apoptotic process, cellular response to estrogen stimulus, ...
Component	cytoplasm, IPAF inflammasome complex, ...
Function	ATP binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (23)    Tissues (21)    Images (2)
Theiler Stages: 17, 22, 23, 28

Assay Type	Results
RNA in situ	13
RT-PCR	10

cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) Genomic(9) cDNA(3) Primer pair(3) Other(1)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000028714 (Evidence)
Ensembl Gene Model	ENSMUSG00000078942 (Evidence)
Entrez Gene	17952 (Evidence)
Consensus CDS Project	CCDS26728.1
International Mouse Knockout Project Status	Naip6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028714	VEGA Gene Model | MGI Sequence Detail	36554	C57BL/6J
transcript	OTTMUST00000071113	VEGA | MGI Sequence Detail	6827	Not Applicable
polypeptide	OTTMUSP00000036369	VEGA | MGI Sequence Detail	1403	Not Applicable

All sequences(28) RefSeq(2) UniProt(3)

Polymorphisms

PCR(2) : SNPs(149 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001370	Baculoviral inhibition of apoptosis protein repeat
InterPro	IPR007111	NACHT nucleoside triphosphatase
Protein Ontology	PR:000011555	baculoviral IAP repeat-containing protein 1f

References

(Earliest) J:37707 Scharf JM, et al., The mouse region syntenic for human spinal muscular atrophy lies within the Lgn1 critical interval and contains multiple copies of Naip exon 5. Genomics. 1996 Dec 15;38(3):405-17
(Latest) J:176197 Kofoed EM, et al., Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature. 2011 Sep 29;477(7366):592-5
All references(29)

Other accession IDs

MGD-MRK-38481, MGI:109436