About   Help   FAQ
Naip5 Gene Detail
Summary
  • Symbol
    Naip5
  • Name
    NLR family, apoptosis inhibitory protein 5
  • Synonyms
    Birc1e, Lgn1, Naip-rs3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298220
    NCBI Gene: 17951
  • Member of
    Naipc cluster
Location & Maps
more
  • Sequence Map
    Chr13:100211739-100246323 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34585 bp   ±  kb flank

  • Genome Browsers
Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Spontaneous
    1
  • Targeted
    2
  • Transgenic
    1
  • Genomic Mutations
    1 involving Naip5
  • Incidental Mutations
This locus controls resistance to Legionella pneumophila, the organism responsible for Legionnaire's disease. Cultured peritoneal macrophages from A/J mice are susceptible, supporting bacterial proliferation; other strains, e.g., C57BL/6 are resistant.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028712 VEGA Gene Model | MGI Sequence Detail 34585 C57BL/6J ±  kb
transcript OTTMUST00000071111 VEGA | MGI Sequence Detail 5204 Not Applicable  
polypeptide OTTMUSP00000036368 VEGA | MGI Sequence Detail 1403 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    71 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000011554 baculoviral IAP repeat-containing protein 1e
  • InterPro Domains
    IPR001370 BIR repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR007111 NACHT nucleoside triphosphatase
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 37
    Genomic 28
    cDNA 6
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16416, MGD-MRK-38482, MGI:109437, MGI:99631
References
more
  • Summaries
    All 61
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 23
  • Earliest
    J:20633 Yoshida S, et al., Genetic control of natural resistance in mouse macrophages regulating intracellular Legionella pneumophila multiplication in vitro. Infect Immun. 1991 Jan;59(1):428-32
  • Latest
    J:217657 Matusiak M, et al., Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1541-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/19/2016
MGI 6.03
The Jackson Laboratory