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Naip5
Gene Detail
 Symbol
Name
ID
Naip5
NLR family, apoptosis inhibitory protein 5
MGI:1298220
Synonyms Birc1e, Lgn1, Naip-rs3
Feature Type protein coding gene
Genetic Map
Chromosome 13
53.05 cM, cytoband D1-D3
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr13:100211739-100246323 bp, - strand
From VEGA annotation of GRCm38

  34585 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:113589  Vertebrate Homology Class
3 mouse; 2 rat

Protein SuperFamily: neuronal apoptosis inhibitory protein
Gene Tree: Naip5

Alleles
and
phenotypes
All alleles(2) : Spontaneous(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
This locus controls resistance to Legionella pneumophila, the organism responsible for Legionnaire's disease. Cultured peritoneal macrophages from A/J mice are susceptible, supporting bacterial proliferation; other strains, e.g., C57BL/6 are resistant.
 
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process apoptotic process, defense response to bacterium, ...
Component cytoplasm, IPAF inflammasome complex, ...
Function ATP binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (89)    Tissues (65)    Images (13)
Theiler Stages: 17, 19, 21, 22, 23, 28
Assay TypeResults
RNA in situ 79
RT-PCR 10
cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(37) Genomic(28) cDNA(6) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000028712 (Evidence)
Ensembl Gene ModelENSMUSG00000071203 (Evidence)
Entrez Gene17951 (Evidence)
UniGene290476
DoTSDT.101126316, DT.91330967, DT.94206983, DT.99846714
Consensus CDS ProjectCCDS26727.1
International Mouse Knockout Project StatusNaip5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028712 VEGA Gene Model | MGI Sequence Detail 34585 C57BL/6J ±  kb
transcript OTTMUST00000071111 VEGA | MGI Sequence Detail 5204 Not Applicable 
polypeptide OTTMUSP00000036368 VEGA | MGI Sequence Detail 1403 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(18) UniProt(8)
Polymorphisms PCR(2) : SNPs within 2kb(297 from dbSNP Build 137)    SNPs within 2kb including multiple locations(399)
Protein-related
information
ResourceIDDescription
InterPro IPR001370 Baculoviral inhibition of apoptosis protein repeat
InterPro IPR007111 NACHT nucleoside triphosphatase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000011554 baculoviral IAP repeat-containing protein 1e
References (Earliest) J:20633 Yoshida S, et al., Genetic control of natural resistance in mouse macrophages regulating intracellular Legionella pneumophila multiplication in vitro. Infect Immun. 1991 Jan;59(1):428-32
(Latest) J:209363 Lopez-Yglesias AH, et al., Flagellin induces antibody responses through a TLR5- and inflammasome-independent pathway. J Immunol. 2014 Feb 15;192(4):1587-96
All references(59)
Other
accession IDs
MGD-MRK-16416, MGD-MRK-38482, MGI:109437, MGI:99631

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory