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F2rl2 Gene Detail
Summary
  • Symbol
    F2rl2
  • Name
    coagulation factor II (thrombin) receptor-like 2
  • Synonyms
    PAR3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298208
    NCBI Gene: 14064
  • Gene Overview
    MyGene.info: F2RL2
Location & Maps
more
  • Sequence Map
    Chr13:95696853-95702739 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5887 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 50.38 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    F2RL2, coagulation factor II thrombin receptor like 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    F2RL2, coagulation factor II thrombin receptor like 2
    Orthology source: HomoloGene
  • Synonyms
    PAR3, PAR-3
  • Links
    NCBI Gene ID: 2151
    neXtProt AC: NX_O00254

  • Chr Location
    5q13; chr5:76615482-76623434 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in prolonged bleeding times, delayed and reduced thrombin responses in platelets, and protection against thrombosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036603 VEGA Gene Model | MGI Sequence Detail 5887 C57BL/6J ±  kb
transcript OTTMUST00000093842 VEGA | MGI Sequence Detail 2502 Not Applicable  
polypeptide OTTMUSP00000052147 VEGA | MGI Sequence Detail 369 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    181 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001663 proteinase-activated receptor 3
  • PDB
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR003912 Protease-activated receptor
    IPR003943 Protease-activated receptor 3
Molecular
Reagents
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  • All nucleic 17
    Genomic 3
    cDNA 11
    Primer pair 2
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 43
    Developmental Gene Expression 6
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:49190 Ishihara H, et al., Protease-activated receptor 3 is a second thrombin receptor in humans. Nature. 1997 Apr 3;386(6624):502-6
  • Latest
    J:224622 Ellery PE, et al., A balance between TFPI and thrombin-mediated platelet activation is required for murine embryonic development. Blood. 2015 Jun 25;125(26):4078-84

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory