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F2rl3 Gene Detail
Summary
  • Symbol
    F2rl3
  • Name
    coagulation factor II (thrombin) receptor-like 3
  • Synonyms
    PAR4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298207
    NCBI Gene: 14065
  • Gene Overview
    MyGene.info: F2RL3
Location & Maps
more
  • Sequence Map
    Chr8:72761880-72763874 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1995 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 35.08 cM, cytoband B3.3
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    F2RL3, F2R like thrombin/trypsin receptor 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    F2RL3, F2R like thrombin/trypsin receptor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PAR4
  • Links
    NCBI Gene ID: 9002
    neXtProt AC: NX_Q96RI0

  • Chr Location
    19p12; chr19:16889015-16892019 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 1 genetic background
    1 phenotype from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving F2rl3
  • Incidental Mutations
Homozygous mutation of this gene results in prolonged bleeding time and protection against thrombosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050147 Ensembl Gene Model | MGI Sequence Detail 1995 C57BL/6J ±  kb
transcript ENSMUST00000058099 Ensembl | MGI Sequence Detail 1751 Not Applicable  
polypeptide ENSMUSP00000054426 Ensembl | MGI Sequence Detail 396 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    17 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001664 proteinase-activated receptor 4
  • PDB
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR003912 Protease-activated receptor
    IPR003944 Protease-activated receptor 4
Molecular
Reagents
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  • All nucleic 15
    Genomic 4
    cDNA 11

    Microarray probesets 3
References
more
  • Summaries
    All 53
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 28
  • Earliest
    J:49283 Kahn ML, et al., A dual thrombin receptor system for platelet activation. Nature. 1998 Aug 13;394(6694):690-4
  • Latest
    J:230686 Miyakawa K, et al., Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice. Blood. 2015 Oct 8;126(15):1835-43

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory