About   Help   FAQ
Sf3b3 Gene Detail
Summary
  • Symbol
    Sf3b3
  • Name
    splicing factor 3b, subunit 3
  • Synonyms
    1810061H24Rik, 5730409A01Rik, D8Ertd633e, mKIAA0017, RSE1, SAP130
  • Feature Type
    protein coding gene
  • IDs
    MGI:1289341
    NCBI Gene: 101943
  • Gene Overview
    MyGene.info: SF3B3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:110810492-110846806 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 57.73 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1289341
protein coding gene Chr8:110810239-110846806 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034128
protein coding gene Chr8:113500775-113537079 (-)
A/J MGP_AJ_G0034107
protein coding gene Chr8:108903693-108940197 (-)
AKR/J MGP_AKRJ_G0034034
protein coding gene Chr8:112093656-112131355 (-)
BALB/cJ MGP_BALBcJ_G0034101
protein coding gene Chr8:109093290-109129601 (-)
C3H/HeJ MGP_C3HHeJ_G0033812
protein coding gene Chr8:112810526-112847765 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034621
protein coding gene Chr8:117495114-117531413 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031563
protein coding gene Chr8:101897559-101932988 (-)
CAST/EiJ MGP_CASTEiJ_G0033139
protein coding gene Chr8:112426154-112462417 (-)
CBA/J MGP_CBAJ_G0033786
protein coding gene Chr8:121482898-121519207 (-)
DBA/2J MGP_DBA2J_G0033941
protein coding gene Chr8:108205332-108241648 (-)
FVB/NJ MGP_FVBNJ_G0033885
protein coding gene Chr8:107161061-107197350 (-)
LP/J MGP_LPJ_G0034031
protein coding gene Chr8:113690354-113726657 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033931
protein coding gene Chr8:124393216-124429509 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034640
protein coding gene Chr8:112063425-112101263 (-)
PWK/PhJ MGP_PWKPhJ_G0032842
protein coding gene Chr8:107783927-107820987 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032681
protein coding gene Chr8:110748094-110785117 (-)
WSB/EiJ MGP_WSBEiJ_G0033255
protein coding gene Chr8:112752459-112788804 (-)



Homology
more
  • Human Ortholog
    SF3B3, splicing factor 3b subunit 3
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SF3B3, splicing factor 3b subunit 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RSE1, SAP130, SF3b130, STAF130
  • Links
    NCBI Gene ID: 23450
    neXtProt AC: NX_Q15393
    UniProt: Q15393

  • Chr Location
    16q22.1; chr16:70523788-70577668 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 6579
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SF3B3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 101943 NCBI Gene Model | MGI Sequence Detail 36315 C57BL/6J ±  kb
transcript NM_133953 RefSeq | MGI Sequence Detail 4299 C57BL/6  
polypeptide Q921M3 UniProt | EBI | MGI Sequence Detail 1217 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000014737 splicing factor 3B subunit 3
  • InterPro Domains
    IPR004871 Cleavage/polyadenylation specificity factor, A subunit, C-terminal
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Molecular
Reagents
less
  • All nucleic 26
    cDNA 24
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1917095, MGI:1917756, MGI:2142412
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory