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Tax1bp1
Gene Detail
Symbol

Name
ID
Tax1bp1
Tax1 (human T cell leukemia virus type I) binding protein 1
MGI:1289308
Synonyms
1200003J11Rik, 1700069J21Rik, D6Ertd404e, D6Ertd772e, T6BP, TXBP151
Feature Type
protein coding gene
Genetic Map
Chromosome 6
25.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:52713729-52766780 bp, + strand
From VEGA annotation of GRCm38

  53052 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4395  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Tax1bp1

Human
homologs
Human Homolog TAX1BP1, Tax1 (human T-cell leukemia virus type I) binding protein 1
NCBI Gene ID 8887
neXtProt AC  NX_Q86VP1
Human Synonyms  CALCOCO3, T6BP, TXBP151
Human Chr (Location)  7p15; chr7:27739373-27829767 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Knockout mice are born alive but fail to thrive and develop inflammatory cardiac valvulitis and dermatitis, die prematurely, and are hypersensitive to low doses of TNF and IL-1beta. In contrast, embryos homozygous for a gene trap mutation die at E13.5 from hemorrhaging and/or cardiac defects.
 
Interactions
Tax1bp1 interacts with 153 markers (Mir1b, Mir22, Mir25, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process apoptotic process, negative regulation of apoptotic process, ...
Function kinase binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (5)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
cDNA source data(349)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(353) cDNA(351) Primer pair(2)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000022785 (Evidence)
Ensembl Gene ModelENSMUSG00000004535 (Evidence)
Entrez Gene52440 (Evidence)
UniGene389757
NIA Mouse Gene IndexU006876, U266916
Consensus CDS ProjectCCDS39490.1
International Mouse Knockout Project StatusTax1bp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022785 VEGA Gene Model | MGI Sequence Detail 53052 C57BL/6J ±  kb
transcript OTTMUST00000054717 VEGA | MGI Sequence Detail 3285 Not Applicable 
polypeptide OTTMUSP00000026144 VEGA | MGI Sequence Detail 814 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(240 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012852 Coiled-coil transcriptional coactivator-like
InterPro IPR015880 Zinc finger, C2H2-like
Protein Ontology PR:000016090 tax1-binding protein 1
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:206485 Nakano S, et al., Commensal microbiota contributes to chronic endocarditis in TAX1BP1 deficient mice. PLoS One. 2013;8(9):e73205
All references(43)
Other
accession IDs
MGI:1196306, MGI:1889378, MGI:1914122, MGI:1920756

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory