Tax1bp1
Gene Detail

Symbol

Name
ID

Tax1bp1
Tax1 (human T cell leukemia virus type I) binding protein 1
MGI:1289308

Synonyms

1200003J11Rik, 1700069J21Rik, D6Ertd404e, D6Ertd772e, T6BP, TXBP151

Feature Type

protein coding gene

Genetic Map

Chromosome 6
25.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr6:52713729-52766780 bp, + strand From VEGA annotation of GRCm38   53052 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:4395  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Tax1bp1

Human
homologs

Human Homolog		TAX1BP1, Tax1 (human T-cell leukemia virus type I) binding protein 1
NCBI Gene ID		8887
neXtProt AC		NX_Q86VP1
Human Synonyms		CALCOCO3, T6BP, TXBP151
Human Chr (Location)		7p15; chr7:27739373-27829767 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Knockout mice are born alive but fail to thrive and develop inflammatory cardiac valvulitis and dermatitis, die prematurely, and are hypersensitive to low doses of TNF and IL-1beta. In contrast, embryos homozygous for a gene trap mutation die at E13.5 from hemorrhaging and/or cardiac defects.

 

Interactions

Tax1bp1 interacts with 153 markers (Mir1b, Mir22, Mir25, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (9 annotations)

Process	apoptotic process, negative regulation of apoptotic process, ...
Component	extracellular vesicular exosome
Function	kinase binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (5)    Tissues (3)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	5

cDNA source data(349)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(353) cDNA(351) Primer pair(2)
Microarray probesets(8)

Other database
links

VEGA Gene Model	OTTMUSG00000022785 (Evidence)
Ensembl Gene Model	ENSMUSG00000004535 (Evidence)
Entrez Gene	52440 (Evidence)
UniGene	389757
NIA Mouse Gene Index	U006876, U266916
Consensus CDS Project	CCDS39490.1
International Mouse Knockout Project Status	Tax1bp1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022785	VEGA Gene Model | MGI Sequence Detail	53052	C57BL/6J
transcript	OTTMUST00000054717	VEGA | MGI Sequence Detail	3285	Not Applicable
polypeptide	OTTMUSP00000026144	VEGA | MGI Sequence Detail	814	Not Applicable

All sequences(59) RefSeq(8) UniProt(4)

Polymorphisms

SNPs within 2kb(240 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR012852	Coiled-coil transcriptional coactivator-like
InterPro	IPR015880	Zinc finger, C2H2-like
Protein Ontology	PR:000016090	tax1-binding protein 1

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:206485 Nakano S, et al., Commensal microbiota contributes to chronic endocarditis in TAX1BP1 deficient mice. PLoS One. 2013;8(9):e73205
All references(44)

Other
accession IDs

MGI:1196306, MGI:1889378, MGI:1914122, MGI:1920756