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Tax1bp1 Gene Detail
Summary
  • Symbol
    Tax1bp1
  • Name
    Tax1 (human T cell leukemia virus type I) binding protein 1
  • Synonyms
    1200003J11Rik, 1700069J21Rik, D6Ertd404e, D6Ertd772e, T6BP, TXBP151
  • Feature Type
    protein coding gene
  • IDs
    MGI:1289308
    NCBI Gene: 52440
  • Gene Overview
    MyGene.info: TAX1BP1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr6:52713729-52766780 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      53052 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 25.70 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    TAX1BP1, Tax1 binding protein 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TAX1BP1, Tax1 binding protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CALCOCO3, T6BP, TXBP151
  • Links
    NCBI Gene ID: 8887
    neXtProt AC: NX_Q86VP1
    UniProt: Q86VP1

  • Chr Location
    7p15.2; chr7:27739373-27829767 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Knockout mice are born alive but fail to thrive and develop inflammatory cardiac valvulitis and dermatitis, die prematurely, and are hypersensitive to low doses of TNF and IL-1beta. In contrast, embryos homozygous for a gene trap mutation die at E13.5 from hemorrhaging and/or cardiac defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    5
  • Tissues
    3
  • cDNA Data
    349
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022785 VEGA Gene Model | MGI Sequence Detail 53052 C57BL/6J ±  kb
    transcript OTTMUST00000054717 VEGA | MGI Sequence Detail 3285 Not Applicable  
    polypeptide OTTMUSP00000026144 VEGA | MGI Sequence Detail 814 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      241 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR012852 Calcium binding and coiled-coil domain-like
    Molecular
    Reagents
    less
    • All nucleic 353
      cDNA 351
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1196306, MGI:1889378, MGI:1914122, MGI:1920756
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:259425 Whang MI, et al., The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells. Immunity. 2017 Mar 21;46(3):405-420
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    06/12/2018
    MGI 6.12     		The Jackson Laboratory