Tax1bp1 MGI Mouse Gene Detail - MGI:1289308 - Tax1 (human T cell leukemia virus type I) binding protein 1

Tax1bp1 Gene Detail

Symbol

Tax1bp1
Name

Tax1 (human T cell leukemia virus type I) binding protein 1
Synonyms

1200003J11Rik, 1700069J21Rik, D6Ertd404e, D6Ertd772e, T6BP, TXBP151

Feature Type

protein coding gene
IDs

MGI:1289308
NCBI Gene: 52440
Gene Overview

MyGene.info: TAX1BP1

Sequence Map

Chr6:52713729-52766780 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

53052 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 25.70 cM
Mapping Data

5 experiments

Human Ortholog

TAX1BP1, Tax1 binding protein 1

Vertebrate Orthologs

11

Human Ortholog

TAX1BP1, Tax1 binding protein 1
Orthology source: HomoloGene, HGNC
Synonyms

CALCOCO3, T6BP, TXBP151
Links

HGNC:11575

NCBI Gene ID: 8887

neXtProt AC: NX_Q86VP1
Chr Location

7p15; chr7:27739373-27829767 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 4395
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
HCOP

human homology predictions: TAX1BP1
Gene Tree

Tax1bp1

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Gene trapped

6
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC

Knockout mice are born alive but fail to thrive and develop inflammatory cardiac valvulitis and dermatitis, die prematurely, and are hypersensitive to low doses of TNF and IL-1beta. In contrast, embryos homozygous for a gene trap mutation die at E13.5 from hemorrhaging and/or cardiac defects.

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All GO Annotations

9
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

5
Tissues

3
cDNA Data

349
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase tax1bp1

ZFIN tax1bp1a, tax1bp1b

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Tax1bp1 interacts with 152 markers (Mir1b, Mir22, Mir25, ...) View All

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All Sequences

57
RefSeq

8
UniProt

4
CCDS

CCDS39490.1
UniGene

389757

			Length	Strain/Species	Flank
genomic	OTTMUSG00000022785	VEGA Gene Model \| MGI Sequence Detail	53052	C57BL/6J	± kb
transcript	OTTMUST00000054717	VEGA \| MGI Sequence Detail	3285	Not Applicable
polypeptide	OTTMUSP00000026144	VEGA \| MGI Sequence Detail	814	Not Applicable

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SNPs within 2kb

241 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000016090 tax1-binding protein 1
InterPro Domains

IPR012852 Calcium binding and coiled-coil domain-like

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All nucleic 353

cDNA 351

Primer pair 2

Microarray probesets 8

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MGI:1196306, MGI:1889378, MGI:1914122, MGI:1920756

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:206485 Nakano S, et al., Commensal microbiota contributes to chronic endocarditis in TAX1BP1 deficient mice. PLoS One. 2013;8(9):e73205

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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