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Scyl2 Gene Detail
Summary
  • Symbol
    Scyl2
  • Name
    SCY1-like 2 (S. cerevisiae)
  • Synonyms
    CVAK104, D10Ertd802e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1289172
    NCBI Gene: 213326
  • Gene Overview
    MyGene.info: SCYL2
Location & Maps
more
  • Sequence Map
    Chr10:89638721-89686285 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      47565 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 45.05 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SCYL2, SCY1 like pseudokinase 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SCYL2, SCY1 like pseudokinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CVAK104
  • Links
    NCBI Gene ID: 55681
    neXtProt AC: NX_Q6P3W7

  • Chr Location
    12q23.1; chr12:100267137-100341722 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Targeted
    5
  • Transposon induced
    1
  • Genomic Mutations
    2 involving Scyl2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit neonatal lethality, absent gastric milk in neonates, postnatal growth retardation, sensory-motor deficits and limb grapsing. Mice homozygous for a conditional allele exhibit similar phenotypes with near complete loss of CA3 neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037018 VEGA Gene Model | MGI Sequence Detail 47565 C57BL/6J ±  kb
transcript OTTMUST00000095202 VEGA | MGI Sequence Detail 4817 Not Applicable  
polypeptide OTTMUSP00000053105 VEGA | MGI Sequence Detail 930 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    442 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    cDNA 64
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2143723, MGI:2143847, MGI:2446127
References
more
  • Summaries
    All 32
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:225808 Gingras S, et al., SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus. J Neurosci. 2015 Jul 22;35(29):10510-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory