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Scyl2 Gene Detail
Summary
  • Symbol
    Scyl2
  • Name
    SCY1-like 2 (S. cerevisiae)
  • Synonyms
    CVAK104, D10Ertd802e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1289172
    NCBI Gene: 213326
  • Gene Overview
    MyGene.info: SCYL2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:89638721-89686285 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 45.05 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    442 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1289172
protein coding gene Chr10:89638720-89686291 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017638
protein coding gene Chr10:90832747-90882863 (-)
A/J MGP_AJ_G0017617
protein coding gene Chr10:87728956-87776516 (-)
AKR/J MGP_AKRJ_G0017575
protein coding gene Chr10:90218813-90267316 (-)
BALB/cJ MGP_BALBcJ_G0017580
protein coding gene Chr10:87989182-88038327 (-)
C3H/HeJ MGP_C3HHeJ_G0017403
protein coding gene Chr10:90226495-90275923 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018037
protein coding gene Chr10:93870564-93926427 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015719
protein coding gene Chr10:83438009-83486957 (-)
CAST/EiJ MGP_CASTEiJ_G0016968
protein coding gene Chr10:90146627-90199512 (-)
CBA/J MGP_CBAJ_G0017372
protein coding gene Chr10:97743398-97794604 (-)
DBA/2J MGP_DBA2J_G0017478
protein coding gene Chr10:86847672-86895879 (-)
FVB/NJ MGP_FVBNJ_G0017470
protein coding gene Chr10:86070371-86118486 (-)
LP/J MGP_LPJ_G0017552
protein coding gene Chr10:91472341-91522583 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017501
protein coding gene Chr10:99224520-99277873 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018074
protein coding gene Chr10:90105024-90157493 (-)
PWK/PhJ MGP_PWKPhJ_G0016749
protein coding gene Chr10:86876744-86926084 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016537
protein coding gene Chr10:88857954-88907074 (-)
WSB/EiJ MGP_WSBEiJ_G0017027
protein coding gene Chr10:90094196-90142558 (-)



Homology
more
  • Human Ortholog
    SCYL2, SCY1 like pseudokinase 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SCYL2, SCY1 like pseudokinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CVAK104
  • Links
    NCBI Gene ID: 55681
    neXtProt AC: NX_Q6P3W7
    UniProt: Q6P3W7

  • Chr Location
    12q23.1; chr12:100267137-100341724 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality, absent gastric milk in neonates, postnatal growth retardation, sensory-motor deficits and limb grapsing. Mice homozygous for a conditional allele exhibit similar phenotypes with near complete loss of CA3 neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000069539 Ensembl Gene Model | MGI Sequence Detail 47565 C57BL/6J ±  kb
transcript ENSMUST00000174252 Ensembl | MGI Sequence Detail 4817 Not Applicable  
polypeptide ENSMUSP00000133992 Ensembl | MGI Sequence Detail 930 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 66
    cDNA 65
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2143723, MGI:2143847, MGI:2446127
References
more
  • Summaries
    All 37
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:225808 Gingras S, et al., SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus. J Neurosci. 2015 Jul 22;35(29):10510-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory