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Pbk
Gene Detail
 Symbol
Name
ID
Pbk
PDZ binding kinase
MGI:1289156
Synonyms 2810434B10Rik, D14Ertd732e, TOPK
Feature Type protein coding gene
Genetic Map
Chromosome 14
34.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:65805837-65817822 bp, + strand
From VEGA annotation of GRCm38

  11986 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32415  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pbk

Human
homologs
Human Homolog PBK, PDZ binding kinase
NCBI Gene ID 55872
neXtProt AC  NX_Q96KB5
Human Synonyms  CT84, HEL164, Nori-3, SPK, TOPK
Human Chr (Location)  8p21.2; chr8:27809621-27838095 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(18) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased UV-induced loss of the horny layer, epidermis thickening, skin fibrosis, and deposition of extracellular matrix in the skin.
 
Interactions
Pbk interacts with 43 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cellular response to UV, negative regulation of inflammatory response, ...
Component cellular_component
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (338)    Tissues (140)    Images (47)
Theiler Stages: 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 338
cDNA source data(64)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(67) cDNA(65) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000027681 (Evidence)
Ensembl Gene ModelENSMUSG00000022033 (Evidence)
Entrez Gene52033 (Evidence)
UniGene24337
DFCITC1574875
DoTSDT.489006
NIA Mouse Gene IndexU015781
EC2.7.12.2
Consensus CDS ProjectCCDS27215.1
International Mouse Knockout Project StatusPbk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027681 VEGA Gene Model | MGI Sequence Detail 11986 C57BL/6J ±  kb
transcript OTTMUST00000068488 VEGA | MGI Sequence Detail 1720 Not Applicable 
polypeptide OTTMUSP00000034645 VEGA | MGI Sequence Detail 330 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000012323 lymphokine-activated killer T-cell-originated protein kinase
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:176985 Li S, et al., T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway. J Biol Chem. 2011 Aug 26;286(34):29601-9
All references(40)
Other
accession IDs
MGI:1913720, MGI:2145824

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory