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Dgkz
Gene Detail
Symbol

Name
ID
Dgkz
diacylglycerol kinase zeta
MGI:1278339
Synonyms
E130307B02Rik, mDGK[z]
Feature Type
protein coding gene
Genetic Map
Chromosome 2
50.63 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:91932824-91975864 bp, - strand
From VEGA annotation of GRCm38

  43041 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37831  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dgkz

Human
homologs
Human Homolog DGKZ, diacylglycerol kinase, zeta
NCBI Gene ID 8525
neXtProt AC  NX_Q13574
Human Synonyms  DAGK5, DAGK6, DGK-ZETA, hDGKzeta
Human Chr (Location)  11p11.2; chr11:46332905-46380554 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(32) Targeted(6)
Genomic Mutations involving Dgkz (2)
Incidental mutations (data from Mutagenetix , APF )
 
The T cell response is enhanced in homozygous mutant mice, which showed a robust response to viral infection.
 
Interactions
Dgkz interacts with 326 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process intracellular signal transduction, lipid phosphorylation, ...
Component cytoplasm, lamellipodium, ...
Function ATP binding, diacylglycerol kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (255)    Tissues (129)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 245
Western blot 8
RT-PCR 2
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(17) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000014363 (Evidence)
Ensembl Gene ModelENSMUSG00000040479 (Evidence)
Entrez Gene104418 (Evidence)
NIA Mouse Gene IndexU023029
EC2.7.1.107
Consensus CDS ProjectCCDS16441.1, CCDS50643.1
International Mouse Knockout Project StatusDgkz
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014363 VEGA Gene Model | MGI Sequence Detail 43041 C57BL/6J ±  kb
transcript OTTMUST00000033981 VEGA | MGI Sequence Detail 4169 Not Applicable 
polypeptide OTTMUSP00000015219 VEGA | MGI Sequence Detail 1123 Not Applicable 

For the selected sequences
All sequences(98) RefSeq(19) UniProt(15)
Polymorphisms
SNPs within 2kb(118 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR016064 ATP-NAD kinase-like domain
InterPro IPR000756 Diacylglycerol kinase, accessory domain
InterPro IPR001206 Diacylglycerol kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
Protein Ontology PR:000006451 diacylglycerol kinase zeta
References
(Earliest) J:48141 Ding L, et al., The cloning and developmental regulation of murine diacylglycerol kinase zeta. FEBS Lett. 1998 Jun 5;429(1):109-14
(Latest) J:207172 You JS, et al., The role of diacylglycerol kinase zeta and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophy. J Biol Chem. 2014 Jan 17;289(3):1551-63
All references(54)
Other
accession IDs
MGI:2445090

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory