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Dgkz Gene Detail
Summary
  • Symbol
    Dgkz
  • Name
    diacylglycerol kinase zeta
  • Synonyms
    E130307B02Rik, mDGK[z]
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278339
    NCBI Gene: 104418
Location & Maps
more
  • Sequence Map
    Chr2:91932824-91975864 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43041 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DGKZ, diacylglycerol kinase zeta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DGKZ, diacylglycerol kinase zeta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DAGK5, DAGK6, DGK-ZETA, hDGKzeta
  • Links
    NCBI Gene ID: 8525
    neXtProt AC: NX_Q13574

  • Chr Location
    11p11.2; chr11:46332905-46380554 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 37831
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DGKZ
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    40
  • Chemically induced (other)
    1
  • Gene trapped
    32
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    4 involving Dgkz
  • Incidental Mutations
The T cell response is enhanced in homozygous mutant mice, which showed a robust response to viral infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014363 VEGA Gene Model | MGI Sequence Detail 43041 C57BL/6J ±  kb
transcript OTTMUST00000033981 VEGA | MGI Sequence Detail 4169 Not Applicable  
polypeptide OTTMUSP00000015219 VEGA | MGI Sequence Detail 1123 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    118 from dbSNP Build 137
Protein
Information
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  • UniProt
    8 Sequences
  • EC
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
    IPR000756 Diacylglycerol kinase, accessory domain
    IPR001206 Diacylglycerol kinase, catalytic domain
    IPR016064 NAD kinase/diacylglycerol kinase-like domain
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Molecular
Reagents
less
  • All nucleic 20
    Genomic 1
    cDNA 17
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2445090
References
more
  • Summaries
    All 51
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 26
  • Earliest
    J:48141 Ding L, et al., The cloning and developmental regulation of murine diacylglycerol kinase zeta. FEBS Lett. 1998 Jun 5;429(1):109-14
  • Latest
    J:227844 Lee D, et al., Functional and Physical Interaction of Diacylglycerol Kinase zeta with Protein Kinase Calpha Is Required for Cerebellar Long-Term Depression. J Neurosci. 2015 Nov 18;35(46):15453-65

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory