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Dgkz Gene Detail
Summary
  • Symbol
    Dgkz
  • Name
    diacylglycerol kinase zeta
  • Synonyms
    E130307B02Rik, mDGK[z]
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278339
    NCBI Gene: 104418
  • Gene Overview
    MyGene.info: DGKZ
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:91932824-91975864 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 50.63 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    119 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1278339
protein coding gene Chr2:91932822-91976443 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026160
protein coding gene Chr2:93316609-93364714 (-)
A/J MGP_AJ_G0026121
protein coding gene Chr2:89558014-89601698 (-)
AKR/J MGP_AKRJ_G0026102
protein coding gene Chr2:92031681-92076816 (-)
BALB/cJ MGP_BALBcJ_G0026130
protein coding gene Chr2:89744064-89787496 (-)
C3H/HeJ MGP_C3HHeJ_G0025881
protein coding gene Chr2:92331709-92380615 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026581
protein coding gene Chr2:96545008-96591419 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023972
protein coding gene Chr2:86051919-86094503 (-)
CAST/EiJ MGP_CASTEiJ_G0025346
protein coding gene Chr2:92871911-92917223 (-)
CBA/J MGP_CBAJ_G0025859
protein coding gene Chr2:99884506-99927356 (-)
DBA/2J MGP_DBA2J_G0025995
protein coding gene Chr2:89154722-89197714 (-)
FVB/NJ MGP_FVBNJ_G0025958
protein coding gene Chr2:88252439-88305798 (-)
LP/J MGP_LPJ_G0026099
protein coding gene Chr2:93514252-93563736 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025984
protein coding gene Chr2:102881753-102928742 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026635
protein coding gene Chr2:92117456-92162307 (-)
PWK/PhJ MGP_PWKPhJ_G0025081
protein coding gene Chr2:88891338-88935888 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024882
protein coding gene Chr2:91678294-91724972 (-)
WSB/EiJ MGP_WSBEiJ_G0025413
protein coding gene Chr2:92720837-92769778 (-)



Homology
more
  • Human Ortholog
    DGKZ, diacylglycerol kinase zeta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DGKZ, diacylglycerol kinase zeta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DAGK5, DAGK6, DGK-ZETA, hDGKzeta
  • Links
    NCBI Gene ID: 8525
    neXtProt AC: NX_Q13574
    UniProt: Q13574

  • Chr Location
    11p11.2; chr11:46332905-46380554 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37831
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DGKZ
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
The T cell response is enhanced in homozygous mutant mice, which showed a robust response to viral infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040479 Ensembl Gene Model | MGI Sequence Detail 43041 C57BL/6J ±  kb
transcript ENSMUST00000111303 Ensembl | MGI Sequence Detail 4169 Not Applicable  
polypeptide ENSMUSP00000106934 Ensembl | MGI Sequence Detail 1123 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • EC
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
    IPR036770 Ankyrin repeat-containing domain superfamily
    IPR037607 Diacylglycerol kinase
    IPR000756 Diacylglycerol kinase, accessory domain
    IPR001206 Diacylglycerol kinase, catalytic domain
    IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal
    IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Molecular
Reagents
less
  • All nucleic 21
    Genomic 1
    cDNA 18
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2445090
References
more
  • Summaries
    All 69
    Developmental Gene Expression 4
    Gene Ontology 10
    Phenotypes 34
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:256898 Benziane B, et al., DGKzeta deficiency protects against peripheral insulin resistance and improves energy metabolism. J Lipid Res. 2017 Dec;58(12):2324-2333

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory