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Zfand5 Gene Detail
Summary
  • Symbol
    Zfand5
  • Name
    zinc finger, AN1-type domain 5
  • Synonyms
    2310057A04Rik, 5830475F03Rik, Za20d2, Zfp216
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278334
    NCBI Gene: 22682
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:21272278-21282289 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 14.32 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    146 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1278334
protein coding gene Chr19:21271891-21286840 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024976
protein coding gene Chr19:19293336-19301997 (+)
A/J MGP_AJ_G0024953
protein coding gene Chr19:18238330-18257225 (+)
AKR/J MGP_AKRJ_G0024923
protein coding gene Chr19:18942621-18954407 (+)
BALB/cJ MGP_BALBcJ_G0024952
protein coding gene Chr19:18251195-18261224 (+)
C3H/HeJ MGP_C3HHeJ_G0024710
protein coding gene Chr19:18898924-18908610 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025394
protein coding gene Chr19:19960654-19974065 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022813
protein coding gene Chr19:18488783-18498836 (+)
CAST/EiJ MGP_CASTEiJ_G0024178
protein coding gene Chr19:18555504-18571934 (+)
CBA/J MGP_CBAJ_G0024688
protein coding gene Chr19:20776844-20786614 (+)
DBA/2J MGP_DBA2J_G0024820
protein coding gene Chr19:18256380-18268938 (+)
FVB/NJ MGP_FVBNJ_G0024781
protein coding gene Chr19:18113033-18123043 (+)
LP/J MGP_LPJ_G0024904
protein coding gene Chr19:19265908-19277842 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024808
protein coding gene Chr19:20908527-20917454 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025449
protein coding gene Chr19:18876933-18887362 (+)
PWK/PhJ MGP_PWKPhJ_G0023927
protein coding gene Chr19:17788502-17802282 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023732
protein coding gene Chr19:18152446-18159438 (+)
WSB/EiJ MGP_WSBEiJ_G0024246
protein coding gene Chr19:18960351-18969095 (+)



Homology
more
  • Human Ortholog
    ZFAND5, zinc finger AN1-type containing 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZFAND5, zinc finger AN1-type containing 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ZA20D2, ZFAND5A, ZNF216
  • Links
    NCBI Gene ID: 7763
    neXtProt AC: NX_O76080
    UniProt: O76080

  • Chr Location
    9q21.13; chr9:72351425-72365247 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 21215
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZFAND5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display resistance to age related obesity and resistance to induced muscular atrophy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024750 Ensembl Gene Model | MGI Sequence Detail 10012 C57BL/6J ±  kb
    transcript ENSMUST00000025659 Ensembl | MGI Sequence Detail 2834 Not Applicable  
    polypeptide ENSMUSP00000025659 Ensembl | MGI Sequence Detail 213 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 1
      cDNA 24
      Primer pair 1
      Other 1

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGI:1919194, MGI:1923353, MGI:2145558
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 8
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:49546 Scott DA, et al., Identification and mutation analysis of a cochlear-expressed, zinc finger protein gene at the DFNB7/11 and dn hearing-loss loci on human chromosome 9q and mouse chromosome 19. Gene. 1998 Jul 30;215(2):461-9
    • Latest
      J:266562 Lee D, et al., ZFAND5/ZNF216 is an activator of the 26S proteasome that stimulates overall protein degradation. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9550-E9559

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory