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Bcl6b
Gene Detail
 Symbol
Name
ID
Bcl6b
B cell CLL/lymphoma 6, member B
MGI:1278332
Synonyms Bazf
Feature Type protein coding gene
Genetic Map
Chromosome 11
42.99 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:70224128-70229798 bp, - strand
From VEGA annotation of GRCm38

  5671 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7243  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: Zinc finger and BTB domain-containing protein
Gene Tree: Bcl6b

Human
homologs
Human Homolog BCL6B, B-cell CLL/lymphoma 6, member B
NCBI Gene ID 255877
neXtProt AC  NX_Q8N143
Human Synonyms  BAZF, ZBTB28, ZNF62
Human Chr (Location)  17p13.1; chr17:7023050-7029642 (+)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Targeted(7)
Incidental mutations (data from APF )
 
Homozygous null mice display decreased CD4+ and CD8+ cell numbers in the thymus. Homozygous mice for one null allele display decreased secondary responses of memory CD8+ T cells.
 
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process negative regulation of transcription from RNA polymerase II promoter
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (177)    Tissues (160)    Images (4)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 169
Northern blot 8
cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(19)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006040 (Evidence)
Ensembl Gene ModelENSMUSG00000000317 (Evidence)
Entrez Gene12029 (Evidence)
UniGene12930
DFCITC1583560
DoTSDT.55141484, DT.99855575
NIA Mouse Gene IndexU032995
Consensus CDS ProjectCCDS24939.1
International Mouse Knockout Project StatusBcl6b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006040 VEGA Gene Model | MGI Sequence Detail 5671 C57BL/6J ±  kb
transcript OTTMUST00000013595 VEGA | MGI Sequence Detail 3366 Not Applicable 
polypeptide OTTMUSP00000006305 VEGA | MGI Sequence Detail 474 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000004701 B-cell CLL/lymphoma 6 member B protein
References (Earliest) J:48309 Okabe S, et al., BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor. Mol Cell Biol. 1998 Jul;18(7):4235-44
(Latest) J:184004 Yu J, et al., Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development. 2012 May;139(10):1863-73
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory