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Bcl6b
Gene Detail
Symbol

Name
ID
Bcl6b
B cell CLL/lymphoma 6, member B
MGI:1278332
Synonyms
Bazf
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.99 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:70224128-70229798 bp, - strand
From VEGA annotation of GRCm38

  5671 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7243  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: BCL6B
Protein SuperFamily: Zinc finger and BTB domain-containing protein
Gene Tree: Bcl6b

Human
homologs
BCL6B, B-cell CLL/lymphoma 6, member B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 255877
neXtProt AC: NX_Q8N143

Human Synonyms: BAZF, ZBTB28, ZNF62

Human Chr (Location): 17p13.1; chr17:7023050-7029642 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Genomic Mutations involving Bcl6b (1)
Incidental mutations (data from APF )
 
Homozygous null mice display decreased CD4+ and CD8+ cell numbers in the thymus. Homozygous mice for one null allele display decreased secondary responses of memory CD8+ T cells.
 
Interactions
Bcl6b interacts with 194 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process negative regulation of transcription from RNA polymerase II promoter
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (177)    Tissues (160)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 169
Northern blot 8
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(19)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000006040 (Evidence)
Ensembl Gene Model ENSMUSG00000000317 (Evidence)
Entrez Gene 12029 (Evidence)
UniGene 12930
DFCI TC1583560
DoTS DT.55141484, DT.99855575
NIA Mouse Gene Index U032995
Consensus CDS Project CCDS24939.1
International Mouse Phenotyping Consortium Status Bcl6b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006040 VEGA Gene Model | MGI Sequence Detail 5671 C57BL/6J ±  kb
transcript OTTMUST00000013595 VEGA | MGI Sequence Detail 3366 Not Applicable 
polypeptide OTTMUSP00000006305 VEGA | MGI Sequence Detail 474 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000210 BTB/POZ domain
InterPro IPR011333 POZ domain
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000004701 B-cell CLL/lymphoma 6 member B protein
References
(Earliest) J:48309 Okabe S, et al., BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor. Mol Cell Biol. 1998 Jul;18(7):4235-44
(Latest) J:213579 Liao HF, et al., DNMT3L promotes quiescence in postnatal spermatogonial progenitor cells. Development. 2014 Jun;141(12):2402-13
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory