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Bcl2a1b Gene Detail
Summary
  • Symbol
    Bcl2a1b
  • Name
    B cell leukemia/lymphoma 2 related protein A1b
  • Synonyms
    A1-b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278326
    NCBI Gene: 12045
  • Gene Overview
    MyGene.info: BCL2A1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:89199273-89207838 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 47.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    9 from dbSNP Build 142
  • Strain Annotations
    10
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1278326
protein coding gene Chr9:89199209-89207838 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035113
protein coding gene Chr9:89851201-89856280 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0035027
protein coding gene Chr9:89055406-89067324 (+)
BALB/cJ MGP_BALBcJ_G0035086
protein coding gene Chr9:86640567-86641415 (+)
C3H/HeJ MGP_C3HHeJ_G0034797
protein coding gene Chr9:89486713-89487643 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035882
protein coding gene Chr9:119924547-119925209 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0034927
protein coding gene Chr9:86020951-86032261 (-)
FVB/NJ MGP_FVBNJ_G0034871
protein coding gene Chr9:85079884-85084915 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0034912
protein coding gene Chr9:97456356-97472989 (+)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0034229
protein coding gene Chr9:89143992-89149670 (+)



Homology
more
  • Human Ortholog
    BCL2A1, BCL2 related protein A1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BCL2A1, BCL2 related protein A1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACC1, ACC-1, ACC2, ACC-2, BCL2L5, BFL1, GRS, HBPA1
  • Links
    NCBI Gene ID: 597
    neXtProt AC: NX_Q16548
    UniProt: Q16548

  • Chr Location
    15q25.1; chr15:79960890-79971301 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from multigenic genotypes
    5 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12045 NCBI Gene Model | MGI Sequence Detail 8566 C57BL/6J ±  kb
transcript NM_007534 RefSeq | MGI Sequence Detail 764 C57BL/6  
polypeptide NP_031560 RefSeq | MGI Sequence Detail 172 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved site
    IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved site
    IPR002475 Bcl2-like
    IPR013282 Bcl-2-related protein A1
    IPR026298 Blc2 family
    IPR036834 Blc2-like superfamily
Molecular
Reagents
less
  • All nucleic 9
    Genomic 1
    cDNA 8

    Microarray probesets 2
References
more
  • Summaries
    All 22
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:47747 Hatakeyama S, et al., Multiple gene duplication and expression of mouse bcl-2-related genes, A1. Int Immunol. 1998 May;10(5):631-7
  • Latest
    J:268123 Mensink M, et al., Anti-apoptotic A1 is not essential for lymphoma development in Emicro-Myc mice but helps sustain transplanted Emicro-Myc tumour cells. Cell Death Differ. 2018 Mar;25(4):795-806

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory