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Epc1 Gene Detail
Summary
  • Symbol
    Epc1
  • Name
    enhancer of polycomb homolog 1
  • Synonyms
    2400007E14Rik, 5730566F07Rik, A930032N02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278322
    NCBI Gene: 13831
  • Gene Overview
    MyGene.info: EPC1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:6435951-6516108 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      80158 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 4.48 cM, cytoband A1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    EPC1, enhancer of polycomb homolog 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EPC1, enhancer of polycomb homolog 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Epl1
  • Links
    NCBI Gene ID: 80314
    neXtProt AC: NX_Q9H2F5
    UniProt: Q9H2F5

  • Chr Location
    10p11.22; chr10:32267716-32378798 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele die prior to P10 (no time point given) and heterozygous mice exhibit impaired skeletal muscle differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000017262 VEGA Gene Model | MGI Sequence Detail 80158 C57BL/6J ±  kb
    transcript OTTMUST00000041772 VEGA | MGI Sequence Detail 3965 Not Applicable  
    polypeptide OTTMUSP00000018778 VEGA | MGI Sequence Detail 813 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      379 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 57
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1916980, MGI:1917905, MGI:1924445
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:43737 Stankunas K, et al., The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals. Development. 1998 Oct;125(20):4055-66
    • Latest
      J:244731 Dong Y, et al., EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice. Mol Cell Biol. 2017 Oct 01;37(19):None

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory