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Epc1 Gene Detail
Summary
  • Symbol
    Epc1
  • Name
    enhancer of polycomb homolog 1 (Drosophila)
  • Synonyms
    2400007E14Rik, 5730566F07Rik, A930032N02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278322
    NCBI Gene: 13831
  • Gene Overview
    MyGene.info: EPC1
Location & Maps
more
  • Sequence Map
    Chr18:6435951-6516108 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      80158 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 4.48 cM, cytoband A1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    EPC1, enhancer of polycomb homolog 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EPC1, enhancer of polycomb homolog 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Epl1
  • Links
    NCBI Gene ID: 80314
    neXtProt AC: NX_Q9H2F5

  • Chr Location
    10p11; chr10:32267716-32378798 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    37
  • Gene trapped
    36
  • Targeted
    1
  • Incidental Mutations
Mice homozygous for a gene trap allele die prior to P10 (no time point given) and heterozygous mice exhibit impaired skeletal muscle differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017262 VEGA Gene Model | MGI Sequence Detail 80158 C57BL/6J ±  kb
transcript OTTMUST00000041772 VEGA | MGI Sequence Detail 3965 Not Applicable  
polypeptide OTTMUSP00000018778 VEGA | MGI Sequence Detail 813 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    379 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000007116 enhancer of polycomb homolog 1
  • InterPro Domains
    IPR009607 Enhancer of polycomb, C-terminal
    IPR019542 Enhancer of polycomb-like, N-terminal
    IPR024943 Enhancer of polycomb protein
Molecular
Reagents
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  • All nucleic 57
    cDNA 57

    Microarray probesets 4
Other
Accession IDs
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MGI:1916980, MGI:1917905, MGI:1924445
References
more
  • Summaries
    All 37
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:43737 Stankunas K, et al., The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals. Development. 1998 Oct;125(20):4055-66
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory