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Epc2 Gene Detail
Summary
  • Symbol
    Epc2
  • Name
    enhancer of polycomb homolog 2
  • Synonyms
    D2Ertd694e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278321
    NCBI Gene: 227867
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:49451486-49551942 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 28.62 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    307 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1278321
protein coding gene Chr2:49451486-49551948 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025722
protein coding gene Chr2:48624577-48726397 (+)
A/J MGP_AJ_G0025698
protein coding gene Chr2:46787441-46881555 (+)
AKR/J MGP_AKRJ_G0025668
protein coding gene Chr2:48127773-48228872 (+)
BALB/cJ MGP_BALBcJ_G0025693
protein coding gene Chr2:46904448-47000032 (+)
C3H/HeJ MGP_C3HHeJ_G0025454
protein coding gene Chr2:48110789-48211217 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026139
protein coding gene Chr2:50110271-50208004 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023545
protein coding gene Chr2:44830149-44924118 (+)
CAST/EiJ MGP_CASTEiJ_G0024919
protein coding gene Chr2:48173859-48271481 (+)
CBA/J MGP_CBAJ_G0025434
protein coding gene Chr2:51969840-52085124 (+)
DBA/2J MGP_DBA2J_G0025565
protein coding gene Chr2:46408960-46506508 (+)
FVB/NJ MGP_FVBNJ_G0025527
protein coding gene Chr2:46130396-46235897 (+)
LP/J MGP_LPJ_G0025653
protein coding gene Chr2:48559974-48663889 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025558
protein coding gene Chr2:53025921-53157697 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026197
protein coding gene Chr2:48028390-48129905 (+)
PWK/PhJ MGP_PWKPhJ_G0024660
protein coding gene Chr2:46292178-46384085 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024466
protein coding gene Chr2:48196252-48298646 (+)
WSB/EiJ MGP_WSBEiJ_G0024986
protein coding gene Chr2:48289833-48386315 (+)



Homology
more
  • Human Ortholog
    EPC2, enhancer of polycomb homolog 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    EPC2, enhancer of polycomb homolog 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPC-LIKE
  • Links
    NCBI Gene ID: 26122
    neXtProt AC: NX_Q52LR7
    UniProt: Q52LR7

  • Chr Location
    2q23.1; chr2:148644780-148788491 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32274
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EPC2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 227867 NCBI Gene Model | MGI Sequence Detail 100457 C57BL/6J ±  kb
transcript NM_172663 RefSeq | MGI Sequence Detail 4358 C57BL/6  
polypeptide Q8C0I4 UniProt | EBI | MGI Sequence Detail 808 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 83
    cDNA 82
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1277221
References
more
  • Summaries
    All 42
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:43737 Stankunas K, et al., The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals. Development. 1998 Oct;125(20):4055-66
  • Latest
    J:243553 Fisher CL, et al., An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers. Nucleic Acids Res. 2017 Dec 1;45(21):e174

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory