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Epc2 Gene Detail
Summary
  • Symbol
    Epc2
  • Name
    enhancer of polycomb homolog 2 (Drosophila)
  • Synonyms
    D2Ertd694e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278321
    NCBI Gene: 227867
Location & Maps
more
  • Sequence Map
    Chr2:49451486-49551948 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      100463 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 28.62 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    EPC2, enhancer of polycomb homolog 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    EPC2, enhancer of polycomb homolog 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPC-LIKE
  • Links
    NCBI Gene ID: 26122
    neXtProt AC: NX_Q52LR7

  • Chr Location
    2q23.1; chr2:148644811-148788491 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 32274
    1 human;1 mouse;2 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: EPC2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    45
  • Chemically induced (other)
    1
  • Gene trapped
    40
  • Targeted
    4
  • Genomic Mutations
    1 involving Epc2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012480 VEGA Gene Model | MGI Sequence Detail 100463 C57BL/6J ±  kb
transcript OTTMUST00000029659 VEGA | MGI Sequence Detail 4697 Not Applicable  
polypeptide OTTMUSP00000013338 VEGA | MGI Sequence Detail 808 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    307 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007117 enhancer of polycomb homolog 2
  • InterPro Domains
    IPR009607 Enhancer of polycomb, C-terminal
    IPR019542 Enhancer of polycomb-like, N-terminal
    IPR024943 Enhancer of polycomb protein
Molecular
Reagents
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  • All nucleic 82
    cDNA 81
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:1277221
References
more
  • Summaries
    All 37
    Gene Ontology 3
    Phenotypes 14
  • Earliest
    J:43737 Stankunas K, et al., The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals. Development. 1998 Oct;125(20):4055-66
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory