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Shmt2
Gene Detail
Symbol

Name
ID
Shmt2
serine hydroxymethyltransferase 2 (mitochondrial)
MGI:1277989
Synonyms
2700043D08Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 10
74.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:127517123-127522444 bp, - strand
From NCBI annotation of GRCm38

  5322 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133984  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: serine/glycine hydroxymethyltransferase
Gene Tree: Shmt2

Human
homologs
Human Homolog SHMT2, serine hydroxymethyltransferase 2 (mitochondrial)
NCBI Gene ID 6472
neXtProt AC  NX_P34897
Human Synonyms  GLYA, HEL-S-51e, SHMT
Human Chr (Location)  12q12-q14; chr12:57229573-57234935 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(10) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Shmt2 interacts with 82 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (52)    Tissues (8)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 48
RT-PCR 4
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(13) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000025403 (Evidence)
Entrez Gene108037 (Evidence)
DFCITC1573568, TC1736733
DoTSDT.110983959, DT.494654, DT.94410391, DT.97416352
NIA Mouse Gene IndexU032339
EC2.1.2.1
Consensus CDS ProjectCCDS24244.1
International Mouse Knockout Project StatusShmt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 108037 NCBI Gene Model | MGI Sequence Detail 5322 C57BL/6J ±  kb
transcript NM_028230 RefSeq | MGI Sequence Detail 2305 C57BL/6 
polypeptide NP_082506 RefSeq | MGI Sequence Detail 504 C57BL/6 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(86 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
InterPro IPR001085 Serine hydroxymethyltransferase
InterPro IPR019798 Serine hydroxymethyltransferase, pyridoxal phosphate binding site
Protein Ontology PR:000014848 serine hydroxymethyltransferase, mitochondrial
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(37)
Other
accession IDs
MGI:1919660, MGI:2143464, MGI:2143516

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory