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Thumpd3 Gene Detail
Summary
  • Symbol
    Thumpd3
  • Name
    THUMP domain containing 3
  • Synonyms
    Gtrosa26as
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277973
    NCBI Gene: 14911
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:113023292-113045239 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 52.73 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    455 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277973
 protein coding gene Chr6:113023186-113045239 (+)
129S1/SvImJ ENSMUSG00200025296
 protein coding gene Chr6:110072897-110094947 (+)
A/J ENSMUSG00195016678
 protein coding gene Chr6:109745323-109767375 (+)
AKR/J ENSMUSG00220030922
 protein coding gene Chr6:108668660-108690697 (+)
BALB/cJ ENSMUSG00180002275
 protein coding gene Chr6:110110057-110132109 (+)
C3H/HeJ ENSMUSG00175029658
 protein coding gene Chr6:67276347-67298382 (-)
C57BL/6NJ ENSMUSG00215012142
 protein coding gene Chr6:110104522-110126574 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028714
 protein coding gene Chr6:108125047-108147983 (+)
CAST/EiJ ENSTCUG00005029302
 protein coding gene Chr6:109915659-109937738 (+)
CBA/J ENSMUSG00210019846
 protein coding gene Chr6:109928585-109950619 (+)
DBA/2J ENSMUSG00185017372
 protein coding gene Chr6:110304118-110326135 (+)
FVB/NJ ENSMUSG00205019601
 protein coding gene Chr6:109003986-109026005 (+)
JF1/MsJ ENSUMUG00000009261
 protein coding gene Chr6:109033292-109055351 (+)
LP/J ENSMUSG00230043652
 protein coding gene Chr6:111574236-111596285 (+)
NOD/ShiLtJ ENSMUSG00190017990
 protein coding gene Chr6:109502796-109524814 (+)
NZO/HlLtJ ENSMUSG00225047497
 protein coding gene Chr6:113518412-113540428 (+)
PWK/PhJ ENSLUMG00010025524
 protein coding gene Chr6:108525710-108547751 (+)
SPRET/EiJ ENSMSPG00010043866
 protein coding gene Chr6:111303593-111325574 (+)
WSB/EiJ ENSIUOG00005021730
 protein coding gene Chr6:110256742-110278789 (+)



Homology
more
  • Human Ortholog
    THUMPD3, THUMP domain 3 tRNA guanosine methyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THUMPD3, THUMP domain 3 tRNA guanosine methyltransferase
  • Links
    NCBI Gene ID: 25917
    UniProt: Q9BV44

  • Chr Location
    3p25.3; chr3:9362967-9386791 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    641
  • Tissues
    28
  • cDNA Data
    91
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 14911 NCBI Gene Model | MGI Sequence Detail 21948 C57BL/6J ±  kb
transcript NM_001409955 RefSeq | MGI Sequence Detail 2706 C57BL/6  
polypeptide P97770 UniProt | EBI | MGI Sequence Detail 505 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000032109 tRNA (guanine(6)-N(2))-methyltransferase THUMP3
    (term hierarchy)
  • EC
    2.1.1.-, 2.1.1.256
  • InterPro Domains
    IPR053943 Ribosomal RNA large subunit methyltransferase K/L-like, conserved site
    IPR000241 Ribosomal RNA large subunit methyltransferase K/L-like, methyltransferase domain
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    IPR004114 THUMP domain
Molecular
Reagents
less
  • All nucleic 94
    Genomic 1
    cDNA 92
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141705
References
more
  • Summaries
    All 47
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:79478 Friedrich G, et al., Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 1991 Sep;5(9):1513-23
  • Latest
    J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory