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Zfp143 Gene Detail
Summary
  • Symbol
    Zfp143
  • Name
    zinc finger protein 143
  • Synonyms
    D7Ertd805e, KRAB14, pHZ-1, Staf, Zfp79, Zfp80-rs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277969
    NCBI Gene: 20841
  • Gene Overview
    MyGene.info: ZNF143
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:110061670-110095396 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 57.70 cM, cytoband E3-F1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    363 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277969
protein coding gene Chr7:110061217-110095396 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032854
protein coding gene Chr7:113524985-113559296 (+)
A/J MGP_AJ_G0032838
protein coding gene Chr7:110709720-110743183 (+)
AKR/J MGP_AKRJ_G0032769
protein coding gene Chr7:113494812-113529415 (+)
BALB/cJ MGP_BALBcJ_G0032842
protein coding gene Chr7:110408169-110441939 (+)
C3H/HeJ MGP_C3HHeJ_G0032552
protein coding gene Chr7:113524248-113559521 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033348
protein coding gene Chr7:118229482-118266229 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030320
protein coding gene Chr7:112286253-112323961 (+)
CAST/EiJ MGP_CASTEiJ_G0031880
protein coding gene Chr7:105064968-105100026 (+)
CBA/J MGP_CBAJ_G0032525
protein coding gene Chr7:122090433-122123938 (+)
DBA/2J MGP_DBA2J_G0032677
protein coding gene Chr7:108818303-108852663 (+)
FVB/NJ MGP_FVBNJ_G0032630
protein coding gene Chr7:108674048-108708199 (+)
LP/J MGP_LPJ_G0032771
protein coding gene Chr7:115055620-115089808 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032662
protein coding gene Chr7:123753400-123788198 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033369
protein coding gene Chr7:112503699-112537620 (+)
PWK/PhJ MGP_PWKPhJ_G0031587
protein coding gene Chr7:101639047-101673490 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031435
protein coding gene Chr7:99206234-99241742 (+)
WSB/EiJ MGP_WSBEiJ_G0031993
protein coding gene Chr7:113359071-113395577 (+)



Homology
more
  • Human Ortholog
    ZNF143, zinc finger protein 143
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZNF143, zinc finger protein 143
    Orthology source: HomoloGene, HGNC
  • Synonyms
    pHZ-1, SBF, STAF
  • Links
    NCBI Gene ID: 7702
    neXtProt AC: NX_P52747
    UniProt: P52747

  • Chr Location
    11p15.4; chr11:9460965-9528524 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56444
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZNF143
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous disruption of this locus results in fertility defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20841 NCBI Gene Model | MGI Sequence Detail 33727 C57BL/6J ±  kb
    transcript NM_009281 RefSeq | MGI Sequence Detail 3013 C57BL/6  
    polypeptide O70230 UniProt | EBI | MGI Sequence Detail 638 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 1
      cDNA 60
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36359, MGI:107782, MGI:1289198, MGI:2141851, MGI:2142118
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:200454 Ngondo-Mbongo RP, et al., Modulation of gene expression via overlapping binding sites exerted by ZNF143, Notch1 and THAP11. Nucleic Acids Res. 2013 Apr;41(7):4000-14

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory