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Zfp143 Gene Detail
Summary
  • Symbol
    Zfp143
  • Name
    zinc finger protein 143
  • Synonyms
    D7Ertd805e, KRAB14, pHZ-1, Staf, Zfp79, Zfp80-rs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277969
    NCBI Gene: 20841
  • Gene Overview
    MyGene.info: ZNF143
Location & Maps
more
  • Sequence Map
    Chr7:110061217-110095394 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34178 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 57.70 cM, cytoband E3-F1
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    ZNF143, zinc finger protein 143
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZNF143, zinc finger protein 143
    Orthology source: HGNC, HomoloGene
  • Synonyms
    pHZ-1, SBF, STAF
  • Links
    NCBI Gene ID: 7702
    neXtProt AC: NX_P52747

  • Chr Location
    11p15.4; chr11:9460965-9528524 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    89
  • Chemically induced (other)
    1
  • Gene trapped
    85
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Zfp143
  • Incidental Mutations
Homozygous disruption of this locus results in fertility defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000060169 VEGA Gene Model | MGI Sequence Detail 34178 C57BL/6J ±  kb
transcript OTTMUST00000147276 VEGA | MGI Sequence Detail 3003 Not Applicable  
polypeptide OTTMUSP00000076658 VEGA | MGI Sequence Detail 638 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    365 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000017716 zinc finger protein 143
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 64
    Genomic 1
    cDNA 59
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-36359, MGI:107782, MGI:1289198, MGI:2141851, MGI:2142118
References
more
  • Summaries
    All 49
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:29678 Bellefroid EJ, et al., Emergence of the ZNF91 Kruppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10757-61
  • Latest
    J:200454 Ngondo-Mbongo RP, et al., Modulation of gene expression via overlapping binding sites exerted by ZNF143, Notch1 and THAP11. Nucleic Acids Res. 2013 Apr;41(7):4000-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory