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Ehhadh Gene Detail
Summary
  • Symbol
    Ehhadh
  • Name
    enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
  • Synonyms
    1300002P22Rik, HD, L-bifunctional enzyme, L-PBE, MFP, MFP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277964
    NCBI Gene: 74147
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:21761287-21787807 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 12.86 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277964
protein coding gene Chr16:21761285-21787834 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022661
protein coding gene Chr16:19195841-19224859 (-)
A/J MGP_AJ_G0022623
protein coding gene Chr16:18284763-18311267 (-)
AKR/J MGP_AKRJ_G0022598
protein coding gene Chr16:19052051-19080377 (-)
BALB/cJ MGP_BALBcJ_G0022627
protein coding gene Chr16:18478122-18509053 (-)
C3H/HeJ MGP_C3HHeJ_G0022392
protein coding gene Chr16:19148527-19179702 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023078
protein coding gene Chr16:19606476-19634629 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020596
protein coding gene Chr16:18981441-19006738 (-)
CAST/EiJ MGP_CASTEiJ_G0021922
protein coding gene Chr16:19140313-19167657 (-)
CBA/J MGP_CBAJ_G0022364
protein coding gene Chr16:20428446-20460942 (-)
DBA/2J MGP_DBA2J_G0022496
protein coding gene Chr16:18269419-18295867 (-)
FVB/NJ MGP_FVBNJ_G0022471
protein coding gene Chr16:18238345-18264595 (-)
LP/J MGP_LPJ_G0022563
protein coding gene Chr16:18948919-18977735 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022491
protein coding gene Chr16:20021033-20060832 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023089
protein coding gene Chr16:18994263-19021057 (-)
PWK/PhJ MGP_PWKPhJ_G0021662
protein coding gene Chr16:18499892-18528906 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021492
protein coding gene Chr16:18771595-18800770 (-)
WSB/EiJ MGP_WSBEiJ_G0021965
protein coding gene Chr16:18959578-18987610 (-)



Homology
more
  • Human Ortholog
    EHHADH, enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EHHADH, enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ECHD, FRTS3, LBFP, LBP, L-PBE, PBFE
  • Links
    NCBI Gene ID: 1962
    neXtProt AC: NX_Q08426
    UniProt: Q08426

  • Chr Location
    3q27.2; chr3:185190624-185282886 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human EHHADH associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    14 phenotypes from multigenic genotypes
    3 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022853 Ensembl Gene Model | MGI Sequence Detail 26521 C57BL/6J ±  kb
transcript ENSMUST00000023559 Ensembl | MGI Sequence Detail 2981 Not Applicable  
polypeptide ENSMUSP00000023559 Ensembl | MGI Sequence Detail 718 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 85
    cDNA 84
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1921397
References
more
  • Summaries
    All 48
    Developmental Gene Expression 10
    Diseases 2
    Gene Ontology 10
    Phenotypes 11
  • Earliest
    J:55395 Qi C, et al., Absence of spontaneous peroxisome proliferation in enoyl-CoA Hydratase/L-3-hydroxyacyl-CoA dehydrogenase-deficient mouse liver. Further support for the role of fatty acyl CoA oxidase in PPARalpha ligand metabolism. J Biol Chem. 1999 May 28;274(22):15775-80
  • Latest
    J:275567 Zurkirchen L, et al., Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Nat Commun. 2019 May 16;10(1):2192

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory