Ehhadh
Gene Detail

Symbol Name ID

Ehhadh enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase MGI:1277964

Synonyms

1300002P22Rik, HD, L-bifunctional enzyme, L-PBE, MFP, MFP1

Feature Type

protein coding gene

Genetic Map

Chromosome 16

12.86 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:21761287-21787844 bp, - strand From VEGA annotation of GRCm38   26558 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1486  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase
Gene Tree: Ehhadh

Human homologs

Human Homolog		EHHADH, enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
NCBI Gene ID		1962
neXtProt AC		NX_Q08426, NX_Q9NY65
Human Synonyms		ECHD, LBFP, LBP, L-PBE, PBFE
Human Chr (Location)		3q26.3-q28; chr3:184908412-184971886 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice homozygous for disruption of this gene display a normal phenotype.

 
Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	acyl-CoA metabolic process, fatty acid beta-oxidation, ...
Component	cytoplasm, cytosol, ...
Function	3-hydroxyacyl-CoA dehydrogenase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (174)    Tissues (131)    Images (51)
Theiler Stages: 15, 19, 22, 23, 26, 28

Assay Type	Results
RNA in situ	159
Northern blot	15

cDNA source data(83)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(84) cDNA(83) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000033863 (Evidence)
Ensembl Gene Model	ENSMUSG00000022853 (Evidence)
Entrez Gene	74147 (Evidence)
UniGene	28100
DFCI	TC1576189
DoTS	DT.533752
NIA Mouse Gene Index	U036902
EC	1.1.1.35, 4.2.1.17, 5.3.3.8
Consensus CDS Project	CCDS28063.1
International Mouse Knockout Project Status	Ehhadh

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033863	VEGA Gene Model | MGI Sequence Detail	26558	C57BL/6J
transcript	OTTMUST00000085347	VEGA | MGI Sequence Detail	3018	Not Applicable
polypeptide	OTTMUSP00000046102	VEGA | MGI Sequence Detail	718	Not Applicable

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(115 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006180	3-hydroxyacyl-CoA dehydrogenase, conserved site
InterPro	IPR006108	3-hydroxyacyl-CoA dehydrogenase, C-terminal
InterPro	IPR006176	3-hydroxyacyl-CoA dehydrogenase, NAD binding
InterPro	IPR008927	6-phosphogluconate dehydrogenase, C-terminal-like
InterPro	IPR001753	Crotonase, core
InterPro	IPR013328	Dehydrogenase, multihelical
InterPro	IPR018376	Enoyl-CoA hydratase/isomerase, conserved site
InterPro	IPR016040	NAD(P)-binding domain
Protein Ontology	PR:000006947	peroxisomal bifunctional enzyme

References

(Earliest) J:55395 Qi C, et al., Absence of spontaneous peroxisome proliferation in enoyl-CoA Hydratase/L-3-hydroxyacyl-CoA dehydrogenase-deficient mouse liver. Further support for the role of fatty acyl CoA oxidase in PPARalpha ligand metabolism. J Biol Chem. 1999 May 28;274(22):15775-80
(Latest) J:193325 Boj SF, et al., Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell. 2012 Dec 21;151(7):1595-607
All references(45)

Other accession IDs

MGI:1921397