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Hus1 Gene Detail
Summary
  • Symbol
    Hus1
  • Name
    HUS1 checkpoint clamp component
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277962
    NCBI Gene: 15574
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:8943137-8961191 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 5.74 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    548 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277962
 protein coding gene Chr11:8943137-8961240 (-)
129S1/SvImJ ENSMUSG00200027906
 protein coding gene Chr11:5916672-5934746 (-)
A/J ENSMUSG00195023451
 protein coding gene Chr11:5798230-5816300 (-)
AKR/J ENSMUSG00220007741
 protein coding gene Chr11:5828410-5846480 (-)
BALB/cJ ENSMUSG00180022001
 protein coding gene Chr11:5815219-5833289 (-)
C3H/HeJ ENSMUSG00175009827
 protein coding gene Chr11:5810036-5828107 (-)
C57BL/6NJ ENSMUSG00215019884
 protein coding gene Chr11:5838396-5856450 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016088
 protein coding gene Chr11:5699184-5719583 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210017944
 protein coding gene Chr11:5811610-5829684 (-)
DBA/2J ENSMUSG00185017307
 protein coding gene Chr11:5909399-5927472 (-)
FVB/NJ ENSMUSG00205023824
 protein coding gene Chr11:5825504-5843588 (-)
JF1/MsJ ENSUMUG00000045973
 protein coding gene Chr11:6082652-6100719 (-)
LP/J ENSMUSG00230031973
 protein coding gene Chr11:6967161-6985231 (-)
NOD/ShiLtJ ENSMUSG00190036449
 protein coding gene Chr11:5811317-5829387 (-)
NZO/HlLtJ ENSMUSG00225025137
 protein coding gene Chr11:9025891-9043975 (-)
PWK/PhJ ENSLUMG00010018170
 protein coding gene Chr11:5788876-5806944 (-)
SPRET/EiJ ENSMSPG00010007637
 protein coding gene Chr11:5863920-5886797 (-)
WSB/EiJ ENSIUOG00005006192
 protein coding gene Chr11:5810593-5828662 (-)



Homology
more
  • Human Ortholog
    HUS1, HUS1 checkpoint clamp component
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HUS1, HUS1 checkpoint clamp component
  • Synonyms
    hHUS1
  • Links
    NCBI Gene ID: 3364
    UniProt: O60921

  • Chr Location
    7p12.3; chr7:47961882-47979682 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 4 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit defects in yolk sac vascularization, placental abnormalities, extensive apoptosis, and midgestational lethality. Mutant cells show increased chromosomal abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    677
  • Tissues
    28
  • cDNA Data
    76
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020413 Ensembl Gene Model | MGI Sequence Detail 18055 C57BL/6J ±  kb
    transcript ENSMUST00000129115 Ensembl | MGI Sequence Detail 4172 Not Applicable  
    polypeptide ENSMUSP00000114339 Ensembl | MGI Sequence Detail 281 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 79
      cDNA 76
      Primer pair 2
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 5
      Gene Ontology 12
      Phenotypes 16
    • Earliest
      J:47011 Kostrub CF, et al., Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage. EMBO J. 1998 Apr 1;17(7):2055-66
    • Latest
      J:326477 Pereira C, et al., Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis. Elife. 2022 Feb 8;11:e68677
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory