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Hus1
Gene Detail
Symbol

Name
ID
Hus1
Hus1 homolog (S. pombe)
MGI:1277962
Feature Type
protein coding gene
Genetic Map
Chromosome 11
5.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr11:8993137-9011191 bp, - strand
From VEGA annotation of GRCm38

  18055 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37932  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cell cycle checkpoint protein, HUS1 type
Gene Tree: Hus1

Human
homologs
Human Homolog HUS1, HUS1 checkpoint homolog (S. pombe)
NCBI Gene ID 3364
neXtProt AC  NX_O60921
Human Synonyms  hHUS1
Human Chr (Location)  7p13-p12; chr7:47963285-47979625 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit defects in yolk sac vascularization, placental abnormalities, extensive apoptosis, and midgestational lethality. Mutant cells show increased chromosomal abnormalities.
 
Interactions
Hus1 interacts with 365 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cellular response to DNA damage stimulus, cellular response to ionizing radiation, ...
Component checkpoint clamp complex, cytoplasm, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (77)    Tissues (26)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 51
Northern blot 26
cDNA source data(75)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(77) cDNA(75) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000005146 (Evidence)
Ensembl Gene ModelENSMUSG00000020413 (Evidence)
Entrez Gene15574 (Evidence)
UniGene42201
DFCITC1582049, TC1667534, TC1603024
DoTSDT.483703, DT.110521517, DT.102556575, DT.102551802
NIA Mouse Gene IndexU032507
Consensus CDS ProjectCCDS24429.1
International Mouse Knockout Project StatusHus1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005146 VEGA Gene Model | MGI Sequence Detail 18055 C57BL/6J ±  kb
transcript OTTMUST00000011503 VEGA | MGI Sequence Detail 4640 Not Applicable 
polypeptide OTTMUSP00000005348 VEGA | MGI Sequence Detail 281 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(6) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(86 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016580 Cell cycle checkpoint, Hus1
InterPro IPR007150 Checkpoint protein Hus1/Mec3
Protein Ontology PR:000008843 checkpoint protein HUS1
References
(Earliest) J:47011 Kostrub CF, et al., Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage. EMBO J. 1998 Apr 1;17(7):2055-66
(Latest) J:195191 Lyndaker AM, et al., Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance. PLoS Genet. 2013 Feb;9(2):e1003320
All references(50)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory