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Hus1 Gene Detail
Summary
  • Symbol
    Hus1
  • Name
    HUS1 checkpoint clamp component
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277962
    NCBI Gene: 15574
Location & Maps
more
  • Sequence Map
    Chr11:8993137-9011191 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18055 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HUS1, HUS1 checkpoint clamp component
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HUS1, HUS1 checkpoint clamp component
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hHUS1
  • Links
    NCBI Gene ID: 3364
    neXtProt AC: NX_O60921

  • Chr Location
    7p12.3; chr7:47963288-47979625 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 4 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    2
  • Targeted
    7
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit defects in yolk sac vascularization, placental abnormalities, extensive apoptosis, and midgestational lethality. Mutant cells show increased chromosomal abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005146 VEGA Gene Model | MGI Sequence Detail 18055 C57BL/6J ±  kb
transcript OTTMUST00000011503 VEGA | MGI Sequence Detail 4640 Not Applicable  
polypeptide OTTMUSP00000005348 VEGA | MGI Sequence Detail 281 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    86 from dbSNP Build 137
  • PCR
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008843 checkpoint protein HUS1
  • InterPro Domains
    IPR016580 Cell cycle checkpoint, Hus1
    IPR007150 Checkpoint protein Hus1/Mec3
Molecular
Reagents
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  • All nucleic 77
    cDNA 75
    Primer pair 1
    Other 1

    Microarray probesets 6
References
more
  • Summaries
    All 47
    Developmental Gene Expression 4
    Gene Ontology 10
    Phenotypes 12
  • Earliest
    J:47011 Kostrub CF, et al., Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage. EMBO J. 1998 Apr 1;17(7):2055-66
  • Latest
    J:195191 Lyndaker AM, et al., Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance. PLoS Genet. 2013 Feb;9(2):e1003320

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory