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Dlg4
Gene Detail
Symbol

Name
ID
Dlg4
discs, large homolog 4 (Drosophila)
MGI:1277959
Synonyms
Dlgh4, PSD95, PSD-95, SAP90, SAP90A
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.96 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:70017085-70045532 bp, + strand
From VEGA annotation of GRCm38

  28448 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1047  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: DLG4
Protein SuperFamily: membrane-associated guanylate kinase (MAGUK) scaffold protein
Gene Tree: Dlg4

Human
homologs
DLG4, discs, large homolog 4 (Drosophila)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1742
neXtProt AC: NX_P78352

Human Synonyms: PSD95, SAP90, SAP-90

Human Chr (Location): 17p13.1; chr17:7189890-7220050 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Genomic Mutations involving Dlg4 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit severely impaired spatial learning, alterations in long-term potentiation and depression, and lack of hyperalgesia responses in a neuropathic pain model.
 
Human Diseases Modeled in Mice Using Dlg4 (2)    Mutations Annotated to Human Diseases (1)   
Interactions
Dlg4 interacts with 162 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (61 records)
Data Summary: Results (160)    Tissues (45)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 125
Western blot 25
cDNA source data(9)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase dlg4 ; ZFIN dlg4b    NEW 
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000006024 (Evidence)
Ensembl Gene Model ENSMUSG00000020886 (Evidence)
Entrez Gene 13385 (Evidence)
DFCI TC1585821, TC1580389, TC1654051, TC1636119
DoTS DT.529975
NIA Mouse Gene Index U012842
Consensus CDS Project CCDS36202.1, CCDS48829.1
International Mouse Phenotyping Consortium Status Dlg4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006024 VEGA Gene Model | MGI Sequence Detail 28448 C57BL/6J ±  kb
transcript OTTMUST00000013521 VEGA | MGI Sequence Detail 3271 Not Applicable 
polypeptide OTTMUSP00000006268 VEGA | MGI Sequence Detail 767 Not Applicable 

For the selected sequences
All sequences(107) RefSeq(38) UniProt(8)
Polymorphisms
SNPs within 2kb(217 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008144 Guanylate kinase
InterPro IPR020590 Guanylate kinase, conserved site
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR019590 Membrane-associated guanylate kinase (MAGUK), PEST domain, N-terminal
InterPro IPR016313 Membrane-associated guanylate kinase (MAGUK) scaffold protein
InterPro IPR019583 PDZ-associated domain of NMDA receptors
InterPro IPR001478 PDZ domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000006514 disks large homolog 4
References
(Earliest) J:48918 Stathakis DG, et al., Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues. Genomics. 1997 Aug 15;44(1):71-82
(Latest) J:218988 Smith KM, et al., Fgfr1 inactivation in the mouse telencephalon results in impaired maturation of interneurons expressing parvalbumin. PLoS One. 2014;9(8):e103696
All references(205)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory