Dlg4
Gene Detail

Symbol

Name
ID

Dlg4
discs, large homolog 4 (Drosophila)
MGI:1277959

Synonyms

Dlgh4, PSD95, PSD-95, SAP90, SAP90A

Feature Type

protein coding gene

Genetic Map

Chromosome 11
42.96 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:70017085-70045532 bp, + strand From VEGA annotation of GRCm38   28448 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:1047  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: membrane-associated guanylate kinase (MAGUK) scaffold protein
Gene Tree: Dlg4

Human
homologs

Human Homolog		DLG4, discs, large homolog 4 (Drosophila)
NCBI Gene ID		1742
neXtProt AC		NX_P78352
Human Synonyms		PSD95, SAP90, SAP-90
Human Chr (Location)		17p13.1; chr17:7189890-7220050 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(9) : Gene trapped(1) Targeted(8)
Genomic Mutations involving Dlg4 (1)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for a targeted null mutation exhibit severely impaired spatial learning, alterations in long-term potentiation and depression, and lack of hyperalgesia responses in a neuropathic pain model.

 
Human Diseases Modeled in Mice Using Dlg4 (2)    Mutations Annotated to Human Diseases (1)   

Interactions

Dlg4 interacts with 162 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (117 annotations)

Process	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering, dendritic spine morphogenesis, ...
Component	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex, cell junction, ...
Function	acetylcholine receptor binding, beta-1 adrenergic receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (59 records)

Data Summary: Results (160)    Tissues (45)    Images (43)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	10
RNA in situ	125
Western blot	25

cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(10) cDNA(10)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000006024 (Evidence)
Ensembl Gene Model	ENSMUSG00000020886 (Evidence)
Entrez Gene	13385 (Evidence)
DFCI	TC1585821, TC1580389, TC1654051, TC1636119
DoTS	DT.529975
NIA Mouse Gene Index	U012842
Consensus CDS Project	CCDS36202.1, CCDS48829.1
International Mouse Knockout Project Status	Dlg4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006024	VEGA Gene Model | MGI Sequence Detail	28448	C57BL/6J
transcript	OTTMUST00000013521	VEGA | MGI Sequence Detail	3271	Not Applicable
polypeptide	OTTMUSP00000006268	VEGA | MGI Sequence Detail	767	Not Applicable

All sequences(122) RefSeq(46) UniProt(15)

Polymorphisms

SNPs within 2kb(217 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR008144	Guanylate kinase
InterPro	IPR020590	Guanylate kinase, conserved site
InterPro	IPR008145	Guanylate kinase/L-type calcium channel
InterPro	IPR019590	Membrane-associated guanylate kinase (MAGUK), PEST domain, N-terminal
InterPro	IPR016313	Membrane-associated guanylate kinase (MAGUK) scaffold protein
InterPro	IPR019583	PDZ-associated domain of NMDA receptors
InterPro	IPR001478	PDZ domain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR001452	Src homology-3 domain
InterPro	IPR011511	Variant SH3
Protein Ontology	PR:000006514	disks large homolog 4

References

(Earliest) J:48918 Stathakis DG, et al., Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues. Genomics. 1997 Aug 15;44(1):71-82
(Latest) J:215025 Harding AM, et al., ASIC2 subunits facilitate expression at the cell surface and confer regulation by PSD-95. PLoS One. 2014;9(4):e93797
All references(200)
Disease annotation references (1)