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Dlg4
Gene Detail
 Symbol
Name
ID
Dlg4
discs, large homolog 4 (Drosophila)
MGI:1277959
Synonyms Dlgh4, PSD95, PSD-95, SAP90, SAP90A
Feature Type protein coding gene
Genetic Map
Chromosome 11
42.96 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:70017085-70045532 bp, + strand
From VEGA annotation of GRCm38

  28448 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1047  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: membrane-associated guanylate kinase (MAGUK) scaffold protein
Gene Tree: Dlg4

Human
homologs
Human Homolog DLG4, discs, large homolog 4 (Drosophila)
NCBI Gene ID 1742
neXtProt AC  NX_P78352
Human Synonyms  PSD95, SAP90, SAP-90
Human Chr (Location)  17p13.1; chr17:7189890-7220050 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit severely impaired spatial learning, alterations in long-term potentiation and depression, and lack of hyperalgesia responses in a neuropathic pain model.
 
Human Diseases Modeled Using Mouse Dlg4 (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Dlg4 interacts with 162 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (108 annotations)
Process alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering, dendritic spine morphogenesis, ...
Component alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex, cell junction, ...
Function acetylcholine receptor binding, beta-1 adrenergic receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (57 records)
Data Summary: Results (160)    Tissues (45)    Images (43)
Theiler Stages: 19, 23, 26, 27, 28
Assay TypeResults
Immunohistochemistry 10
RNA in situ 125
Western blot 25
cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000006024 (Evidence)
Ensembl Gene ModelENSMUSG00000020886 (Evidence)
Entrez Gene13385 (Evidence)
DFCITC1580389, TC1585821, TC1636119, TC1654051
DoTSDT.529975
NIA Mouse Gene IndexU012842
Consensus CDS ProjectCCDS36202.1, CCDS48829.1
International Mouse Knockout Project StatusDlg4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006024 VEGA Gene Model | MGI Sequence Detail 28448 C57BL/6J ±  kb
transcript OTTMUST00000013521 VEGA | MGI Sequence Detail 3271 Not Applicable 
polypeptide OTTMUSP00000006268 VEGA | MGI Sequence Detail 767 Not Applicable 

For the selected sequences
All sequences(115) RefSeq(46) UniProt(8)
Polymorphisms SNPs within 2kb(217 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008144 Guanylate kinase
InterPro IPR020590 Guanylate kinase, conserved site
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR019590 Membrane-associated guanylate kinase (MAGUK), PEST domain, N-terminal
InterPro IPR016313 Membrane-associated guanylate kinase (MAGUK) scaffold protein
InterPro IPR019583 PDZ-associated domain of NMDA receptors
InterPro IPR001478 PDZ domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000006514 disks large homolog 4
References (Earliest) J:48918 Stathakis DG, et al., Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues. Genomics. 1997 Aug 15;44(1):71-82
(Latest) J:208863 Carlyle BC, et al., cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):5036-41
All references(192)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory