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Pcm1 Gene Detail
Summary
  • Symbol
    Pcm1
  • Name
    pericentriolar material 1
  • Synonyms
    2600002H09Rik, 9430077F19Rik, C030044G17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277958
    NCBI Gene: 18536
  • Gene Overview
    MyGene.info: PCM1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:41239752-41332344 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 23.89 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    482 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277958
protein coding gene Chr8:41239641-41334087 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033561
protein coding gene Chr8:40069666-40167061 (+)
A/J MGP_AJ_G0033544
protein coding gene Chr8:38549884-38646225 (+)
AKR/J MGP_AKRJ_G0033467
protein coding gene Chr8:39709352-39805224 (+)
BALB/cJ MGP_BALBcJ_G0033539
protein coding gene Chr8:38667242-38763611 (+)
C3H/HeJ MGP_C3HHeJ_G0033249
protein coding gene Chr8:40102124-40199825 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034055
protein coding gene Chr8:41597007-41694168 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031004
protein coding gene Chr8:35199502-35291522 (+)
CAST/EiJ MGP_CASTEiJ_G0032577
protein coding gene Chr8:39599509-39699211 (+)
CBA/J MGP_CBAJ_G0033227
protein coding gene Chr8:43306381-43405214 (+)
DBA/2J MGP_DBA2J_G0033381
protein coding gene Chr8:38376131-38471287 (+)
FVB/NJ MGP_FVBNJ_G0033325
protein coding gene Chr8:37960951-38057323 (+)
LP/J MGP_LPJ_G0033470
protein coding gene Chr8:40105630-40208355 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033367
protein coding gene Chr8:43056112-43188907 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034073
protein coding gene Chr8:39862030-39964264 (+)
PWK/PhJ MGP_PWKPhJ_G0032286
protein coding gene Chr8:37924834-38022909 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032118
protein coding gene Chr8:39030130-39130730 (+)
WSB/EiJ MGP_WSBEiJ_G0032692
protein coding gene Chr8:40071127-40169620 (+)



Homology
more
  • Human Ortholog
    PCM1, pericentriolar material 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PCM1, pericentriolar material 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PTC4, RET/PCM-1
  • Links
    NCBI Gene ID: 5108
    neXtProt AC: NX_Q15154
    UniProt: Q15154

  • Chr Location
    8p22; chr8:17922763-18029948 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4518
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PCM1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Haploinsufficient mice show a reduced brain size, behavioral impairment to social stimulus and reduced rearing in the open field test.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031592 Ensembl Gene Model | MGI Sequence Detail 92593 C57BL/6J ±  kb
    transcript ENSMUST00000211247 Ensembl | MGI Sequence Detail 6484 Not Applicable  
    polypeptide ENSMUSP00000147887 Ensembl | MGI Sequence Detail 2064 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 18
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1919589, MGI:1924673, MGI:1924736
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 6
      Gene Ontology 21
      Phenotypes 11
    • Earliest
      J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
    • Latest
      J:239231 Zhang B, et al., DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle. J Biol Chem. 2017 Jan 27;292(4):1351-1360

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory