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Pcm1 Gene Detail
Summary
  • Symbol
    Pcm1
  • Name
    pericentriolar material 1
  • Synonyms
    2600002H09Rik, 9430077F19Rik, C030044G17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277958
    NCBI Gene: 18536
  • Gene Overview
    MyGene.info: PCM1
Location & Maps
more
  • Sequence Map
    Chr8:41239759-41334086 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      94328 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 23.89 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PCM1, pericentriolar material 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PCM1, pericentriolar material 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PTC4, RET/PCM-1
  • Links
    NCBI Gene ID: 5108
    neXtProt AC: NX_Q15154

  • Chr Location
    8p22-p21.3; chr8:17922857-18029948 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4518
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PCM1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human PCM1 associations

Human Disease Mouse Models
       Thyroid Cancer, Nonmedullary, 1; NMTC1   OMIM: 188550
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    42
  • Gene trapped
    41
  • Targeted
    1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031592 Ensembl Gene Model | MGI Sequence Detail 94328 C57BL/6J ±  kb
transcript ENSMUST00000045218 Ensembl | MGI Sequence Detail 8380 Not Applicable  
polypeptide ENSMUSP00000039709 Ensembl | MGI Sequence Detail 2025 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    484 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012419 pericentriolar material 1 protein
  • InterPro Domains
    IPR024138 Pericentriolar material 1 protein
    IPR031446 Pericentriolar material 1 protein, C-terminal
Molecular
Reagents
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  • All nucleic 19
    Genomic 1
    cDNA 17
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:1919589, MGI:1924673, MGI:1924736
References
more
  • Summaries
    All 48
    Developmental Gene Expression 6
    Gene Ontology 13
    Phenotypes 9
  • Earliest
    J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
  • Latest
    J:224117 Zoubovsky S, et al., Neuroanatomical and behavioral deficits in mice haploinsufficient for Pericentriolar material 1 (Pcm1). Neurosci Res. 2015 Sep;98:45-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory