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Pycr2 Gene Detail
Summary
  • Symbol
    Pycr2
  • Name
    pyrroline-5-carboxylate reductase family, member 2
  • Synonyms
    1810018M05Rik, P5cr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277956
    NCBI Gene: 69051
Location & Maps
more
  • Sequence Map
    Chr1:180904293-180908088 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3796 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 84.46 cM, cytoband H5
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PYCR2, pyrroline-5-carboxylate reductase family member 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PYCR2, pyrroline-5-carboxylate reductase family member 2
    Orthology source: HomoloGene
  • Synonyms
    HLD10, P5CR2
  • Links
    NCBI Gene ID: 29920
    neXtProt AC: NX_Q96C36

  • Chr Location
    1q42.12; chr1:225919877-225924340 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PYCR2 associations

Human Disease Mouse Models
       Leukodystrophy, Hypomyelinating, 10; HLD10   OMIM: 616420
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Targeted
    2
  • Genomic Mutations
    2 involving Pycr2
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050459 VEGA Gene Model | MGI Sequence Detail 3796 C57BL/6J ±  kb
transcript OTTMUST00000128030 VEGA | MGI Sequence Detail 1580 Not Applicable  
polypeptide OTTMUSP00000068951 VEGA | MGI Sequence Detail 320 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    37 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • EC
  • InterPro Domains
    IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like
    IPR016040 NAD(P)-binding domain
    IPR000304 Pyrroline-5-carboxylate reductase
    IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal
    IPR029036 Pyrroline-5-carboxylate reductase, dimerisation domain
Molecular
Reagents
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  • All nucleic 111
    cDNA 111

    Microarray probesets 3
Other
Accession IDs
less
MGI:1916301
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:49270 Meno C, et al., Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos. Genes Cells. 1997 Aug;2(8):513-24
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory