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Bsn Gene Detail
Summary
  • Symbol
    Bsn
  • Name
    bassoon
  • Synonyms
    presynaptic cytomatrix protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277955
    NCBI Gene: 12217
Location & Maps
more
  • Sequence Map
    Chr9:108096022-108190384 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      94363 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    BSN, bassoon presynaptic cytomatrix protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BSN, bassoon presynaptic cytomatrix protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ZNF231
  • Links
    NCBI Gene ID: 8927
    neXtProt AC: NX_Q9UPA5

  • Chr Location
    3p21.31; chr3:49554489-49671549 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31161
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: BSN
  • Gene Tree
    Bsn
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 1 genetic background
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mutants lacking functional protein exhibit impaired hippocampal and photoreceptor synaptic transmission, aberrant photoreceptor ribbon synapse formation, and spontaneous epileptic seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016899 VEGA Gene Model | MGI Sequence Detail 94363 C57BL/6J ±  kb
transcript OTTMUST00000041006 VEGA | MGI Sequence Detail 15938 Not Applicable  
polypeptide OTTMUSP00000018359 VEGA | MGI Sequence Detail 3942 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    413 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 10
    Genomic 2
    cDNA 8

    Microarray probesets 6
References
more
  • Summaries
    All 81
    Developmental Gene Expression 18
    Gene Ontology 16
    Phenotypes 25
  • Earliest
    J:48938 Dieck S, et al., Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals. J Cell Biol. 1998 Jul 27;142(2):499-509
  • Latest
    J:222854 Laguna A, et al., Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease. Nat Neurosci. 2015 Jun;18(6):826-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory