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Il13ra2 Gene Detail
Summary
  • Symbol
    Il13ra2
  • Name
    interleukin 13 receptor, alpha 2
  • Synonyms
    CD213a2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277954
    NCBI Gene: 16165
  • Gene Overview
    MyGene.info: IL13RA2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:147383478-147429192 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 68.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    135 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277954
protein coding gene ChrX:147383476-147429192 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036164
protein coding gene ChrX:144994916-145041946 (-)
A/J MGP_AJ_G0036141
protein coding gene ChrX:144253139-144302694 (-)
AKR/J MGP_AKRJ_G0036067
protein coding gene ChrX:149013910-149070487 (-)
BALB/cJ MGP_BALBcJ_G0036132
protein coding gene ChrX:142473065-142518227 (-)
C3H/HeJ MGP_C3HHeJ_G0035840
protein coding gene ChrX:145114477-145161401 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036656
protein coding gene ChrX:149089984-149138259 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033481
protein coding gene ChrX:135701502-135742335 (-)
CAST/EiJ MGP_CASTEiJ_G0035131
protein coding gene ChrX:125639415-125673470 (-)
CBA/J MGP_CBAJ_G0035817
protein coding gene ChrX:153728143-153777128 (-)
DBA/2J MGP_DBA2J_G0035975
protein coding gene ChrX:143309577-143356383 (-)
FVB/NJ MGP_FVBNJ_G0035909
protein coding gene ChrX:142532930-142578661 (-)
LP/J MGP_LPJ_G0036066
protein coding gene ChrX:145908382-145954844 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035945
protein coding gene ChrX:161847504-161892571 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036692
protein coding gene ChrX:144259972-144307769 (-)
PWK/PhJ MGP_PWKPhJ_G0034825
protein coding gene ChrX:122392430-122438923 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034651
protein coding gene ChrX:126207418-126254879 (-)
WSB/EiJ MGP_WSBEiJ_G0035266
protein coding gene ChrX:142560811-142606942 (-)



Homology
more
  • Human Ortholog
    IL13RA2, interleukin 13 receptor subunit alpha 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IL13RA2, interleukin 13 receptor subunit alpha 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD213A2, CT19, IL13BP, IL-13R
  • Links
    NCBI Gene ID: 3598
    neXtProt AC: NX_Q14627
    UniProt: Q14627

  • Chr Location
    Xq23; chrX:115003975-115017644 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 534
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: IL13RA2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Null mice display a phenotype consistent with attenuated IL13 responsiveness, including abnormal serum protein concentrations, increased frequency of bone marrow macrophage progenitor cells, and abnormal response of tissue macrophage to LPS.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16165 NCBI Gene Model | MGI Sequence Detail 45715 C57BL/6J ±  kb
    transcript NM_008356 RefSeq | MGI Sequence Detail 2279 C57BL/6  
    polypeptide O88786 UniProt | EBI | MGI Sequence Detail 383 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 5
      Primer pair 3
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:49271 Donaldson DD, et al., The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1. J Immunol. 1998 Sep 1;161(5):2317-24
    • Latest
      J:258853 Zhou Y, et al., Galectin-3 Interacts with the CHI3L1 Axis and Contributes to Hermansky-Pudlak Syndrome Lung Disease. J Immunol. 2018 Mar 15;200(6):2140-2153

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory