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Fhit Gene Detail
Summary
  • Symbol
    Fhit
  • Name
    fragile histidine triad gene
  • Synonyms
    Fra14A2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277947
    NCBI Gene: 14198
  • Gene Overview
    MyGene.info: FHIT
Location & Maps
more
  • Sequence Map
    Chr14:9550092-11162035 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1611944 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 5.61 cM, cytoband A2
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    FHIT, fragile histidine triad
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FHIT, fragile histidine triad
    Orthology source: HomoloGene
  • Synonyms
    AP3Aase, FRA3B
  • Links
    NCBI Gene ID: 2272
    neXtProt AC: NX_P49789

  • Chr Location
    3p14.2; chr3:59747587-61251459 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 21661
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: FHIT
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Fhit mouse models

Human Disease Mouse Models
       Muir-Torre Syndrome; MRTES   OMIM: 158320 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    5
  • Targeted
    2
  • Incidental Mutations
Both homozygotes and heterozygotes for a targeted null mutation exhibit a similarly increased incidence of both spontaneous and nitrosomethylbenzalamine-induced tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034621 VEGA Gene Model | MGI Sequence Detail 1611944 C57BL/6J ±  kb
transcript OTTMUST00000087866 VEGA | MGI Sequence Detail 1094 Not Applicable  
polypeptide OTTMUSP00000047853 VEGA | MGI Sequence Detail 213 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    12527 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 9
    cDNA 7

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145783
References
more
  • Summaries
    All 45
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 7
    Phenotypes 18
  • Earliest
    J:113676 Barnes LD, et al., Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5''-P1,P3-triphosphate hydrolase. Biochemistry. 1996 Sep 10;35(36):11529-35
  • Latest
    J:194670 Saldivar JC, et al., Initiation of genome instability and preneoplastic processes through loss of Fhit expression. PLoS Genet. 2012 Nov;8(11):e1003077

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory