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Fhit
Gene Detail
Symbol

Name
ID
Fhit
fragile histidine triad gene
MGI:1277947
Synonyms
Fra14A2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
5.61 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr14:9550092-11162035 bp, - strand
From VEGA annotation of GRCm38

  1611944 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21661  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: FHIT
Gene Tree: Fhit

Human
homologs
FHIT, fragile histidine triad
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2272
neXtProt AC: NX_P49789

Human Synonyms: AP3Aase, FRA3B

Human Chr (Location): 3p14.2; chr3:59747587-61251459 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(5) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Both homozygotes and heterozygotes for a targeted null mutation exhibit a similarly increased incidence of both spontaneous and nitrosomethylbenzalamine-induced tumors.
 
Human Diseases Modeled in Mice Using Fhit (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Fhit interacts with 46 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process apoptotic process, diadenosine triphosphate catabolic process, ...
Component cytoplasm, cytosol, ...
Function bis(5'-adenosyl)-triphosphatase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (105)    Tissues (105)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Western blot 11
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fhit ; ZFIN fhit    NEW 
Molecular
reagents
All nucleic(16) Genomic(9) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000034621 (Evidence)
Ensembl Gene Model ENSMUSG00000060579 (Evidence)
Entrez Gene 14198 (Evidence)
DFCI TC1585564
DoTS DT.484830, DT.91338875, DT.94293887
NIA Mouse Gene Index U309048
EC 3.6.1.29
Consensus CDS Project CCDS49400.1
International Mouse Phenotyping Consortium Status Fhit
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034621 VEGA Gene Model | MGI Sequence Detail 1611944 C57BL/6J ±  kb
transcript OTTMUST00000087866 VEGA | MGI Sequence Detail 1094 Not Applicable 
polypeptide OTTMUSP00000047853 VEGA | MGI Sequence Detail 213 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(14) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(12697 from dbSNP Build 137)    SNPs within 2kb including multiple locations(12719)
Protein-related
information
ResourceIDDescription
InterPro IPR019808 Histidine triad, conserved site
InterPro IPR001310 Histidine triad (HIT) protein
InterPro IPR011146 HIT-like domain
Protein Ontology PR:000007512 bis(5'-adenosyl)-triphosphatase
References
(Earliest) J:113676 Barnes LD, et al., Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5''-P1,P3-triphosphate hydrolase. Biochemistry. 1996 Sep 10;35(36):11529-35
(Latest) J:194670 Saldivar JC, et al., Initiation of genome instability and preneoplastic processes through loss of Fhit expression. PLoS Genet. 2012 Nov;8(11):e1003077
All references(48)
Disease annotation references (1)
Other
accession IDs
MGI:2145783

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory