Fhit
Gene Detail

Symbol Name ID

Fhit fragile histidine triad gene MGI:1277947

Synonyms

Fra14A2

Feature Type

protein coding gene

Genetic Map

Chromosome 14

5.61 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr14:9550092-11162035 bp, - strand From VEGA annotation of GRCm38   1611944 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21661  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Fhit

Human homologs

Human Homolog		FHIT, fragile histidine triad
NCBI Gene ID		2272
neXtProt AC		NX_P49789
Human Synonyms		AP3Aase, FRA3B
Human Chr (Location)		3p14.2; chr3:59735036-61237133 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(2) Gene trapped(5)
 

Both homozygotes and heterozygotes for a targeted null mutation exhibit a similarly increased incidence of both spontaneous and nitrosomethylbenzalamine-induced tumors.

 
Human Diseases Modeled Using Mouse Fhit (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	diadenosine triphosphate catabolic process, DNA replication, ...
Component	cytoplasm, intracellular membrane-bounded organelle, ...
Function	bis(5'-adenosyl)-triphosphatase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (105)    Tissues (105)    Images (1)
Theiler Stages: 22, 28

Assay Type	Results
RNA in situ	94
Western blot	11

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) Genomic(9) cDNA(7)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000034621 (Evidence)
Ensembl Gene Model	ENSMUSG00000060579 (Evidence)
Entrez Gene	14198 (Evidence)
DFCI	TC1585564
DoTS	DT.484830, DT.91338875, DT.94293887
NIA Mouse Gene Index	U309048
EC	3.6.1.29
Consensus CDS Project	CCDS49400.1
International Mouse Knockout Project Status	Fhit

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034621	VEGA Gene Model | MGI Sequence Detail	1611944	C57BL/6J
transcript	OTTMUST00000087866	VEGA | MGI Sequence Detail	1094	Not Applicable
polypeptide	OTTMUSP00000047853	VEGA | MGI Sequence Detail	213	Not Applicable

All sequences(51) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(9677 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019808	Histidine triad, conserved site
InterPro	IPR001310	Histidine triad (HIT) protein
InterPro	IPR011146	HIT-like domain
Protein Ontology	PR:000007512	bis(5'-adenosyl)-triphosphatase

References

(Earliest) J:113676 Barnes LD, et al., Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5''-P1,P3-triphosphate hydrolase. Biochemistry. 1996 Sep 10;35(36):11529-35
(Latest) J:185447 Romero I, et al., The tumour suppressor Fhit positively regulates MHC class I expression on cancer cells. J Pathol. 2012 Jul;227(3):367-79
All references(48)

Other accession IDs

MGI:2145783