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Fhit
Gene Detail
 Symbol
Name
ID
Fhit
fragile histidine triad gene
MGI:1277947
Synonyms Fra14A2
Feature Type protein coding gene
Genetic Map
Chromosome 14
5.61 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr14:9550092-11162035 bp, - strand
From VEGA annotation of GRCm38

  1611944 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21661  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Fhit

Human
homologs
Human Homolog FHIT, fragile histidine triad
NCBI Gene ID 2272
neXtProt AC  NX_P49789
Human Synonyms  AP3Aase, FRA3B
Human Chr (Location)  3p14.2; chr3:59749310-61251459 (-)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Targeted(2) Gene trapped(5)
 
Both homozygotes and heterozygotes for a targeted null mutation exhibit a similarly increased incidence of both spontaneous and nitrosomethylbenzalamine-induced tumors.
 
Human Diseases Modeled Using Mouse Fhit (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process apoptotic process, diadenosine triphosphate catabolic process, ...
Component cytoplasm, cytosol, ...
Function bis(5'-adenosyl)-triphosphatase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (105)    Tissues (105)    Images (1)
Theiler Stages: 22, 28
Assay TypeResults
RNA in situ 94
Western blot 11
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(16) Genomic(9) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000034621 (Evidence)
Ensembl Gene ModelENSMUSG00000060579 (Evidence)
Entrez Gene14198 (Evidence)
DFCITC1585564
DoTSDT.484830, DT.91338875, DT.94293887
NIA Mouse Gene IndexU309048
EC3.6.1.29
Consensus CDS ProjectCCDS49400.1
International Mouse Knockout Project StatusFhit
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034621 VEGA Gene Model | MGI Sequence Detail 1611944 C57BL/6J ±  kb
transcript OTTMUST00000087866 VEGA | MGI Sequence Detail 1094 Not Applicable 
polypeptide OTTMUSP00000047853 VEGA | MGI Sequence Detail 213 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(16) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(12697 from dbSNP Build 137)    SNPs within 2kb including multiple locations(12719)
Protein-related
information
ResourceIDDescription
InterPro IPR019808 Histidine triad, conserved site
InterPro IPR001310 Histidine triad (HIT) protein
InterPro IPR011146 HIT-like domain
Protein Ontology PR:000007512 bis(5'-adenosyl)-triphosphatase
References (Earliest) J:113676 Barnes LD, et al., Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5''-P1,P3-triphosphate hydrolase. Biochemistry. 1996 Sep 10;35(36):11529-35
(Latest) J:194670 Saldivar JC, et al., Initiation of genome instability and preneoplastic processes through loss of Fhit expression. PLoS Genet. 2012 Nov;8(11):e1003077
All references(50)
Other
accession IDs
MGI:2145783

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory