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Septin11 Gene Detail
Summary
  • Symbol
    Septin11
  • Name
    septin 11
  • Synonyms
    6230410I01Rik, D5Ertd606e, Sept11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277214
    NCBI Gene: 52398
  • Gene Overview
    MyGene.info: SEPTIN11
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:93093437-93176447 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 47.29 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    824 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277214
protein coding gene Chr5:93090995-93182368 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029758
protein coding gene Chr5:94312794-94397468 (+)
A/J MGP_AJ_G0029724
protein coding gene Chr5:90554966-90642030 (+)
AKR/J MGP_AKRJ_G0029670
protein coding gene Chr5:93547643-93630940 (+)
BALB/cJ MGP_BALBcJ_G0029734
protein coding gene Chr5:91436116-91520866 (+)
C3H/HeJ MGP_C3HHeJ_G0029457
protein coding gene Chr5:93930597-94013443 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030188
protein coding gene Chr5:98051345-98138201 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027424
protein coding gene Chr5:86183627-86267053 (+)
CAST/EiJ MGP_CASTEiJ_G0028867
protein coding gene Chr5:93315138-93400413 (+)
CBA/J MGP_CBAJ_G0029427
protein coding gene Chr5:101469544-101553985 (+)
DBA/2J MGP_DBA2J_G0029571
protein coding gene Chr5:90607684-90690339 (+)
FVB/NJ MGP_FVBNJ_G0029530
protein coding gene Chr5:89467369-89550456 (+)
LP/J MGP_LPJ_G0029659
protein coding gene Chr5:94678001-94762622 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029559
protein coding gene Chr5:106346516-106431789 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030222
protein coding gene Chr5:93049864-93144076 (+)
PWK/PhJ MGP_PWKPhJ_G0028586
protein coding gene Chr5:89673168-89757335 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028421
protein coding gene Chr5:92396399-92481079 (+)
WSB/EiJ MGP_WSBEiJ_G0028946
protein coding gene Chr5:93527454-93611560 (+)



Homology
more
  • Human Ortholog
    SEPTIN11, septin 11
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SEPTIN11, septin 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SEPT11
  • Links
    NCBI Gene ID: 55752
    neXtProt AC: NX_Q9NVA2
    UniProt: Q9NVA2

  • Chr Location
    4q21.1; chr4:76949714-77040154 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic growth retardation and complete embryonic lethality during organogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000058013 Ensembl Gene Model | MGI Sequence Detail 83011 C57BL/6J ±  kb
    transcript ENSMUST00000202217 Ensembl | MGI Sequence Detail 1380 Not Applicable  
    polypeptide ENSMUSP00000144235 Ensembl | MGI Sequence Detail 432 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 26
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1915030, MGI:2141224
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:205987 Ageta-Ishihara N, et al., Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation. Nat Commun. 2013;4:2532

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/13/2020
    MGI 6.16
    The Jackson Laboratory