Zfp644 Gene Detail

Summary

• Symbol
  Zfp644
• Name
  zinc finger protein 644
• Synonyms
  1110068L01Rik, BM-005, D5Ertd689e, mKIAA1221, Zep-2

• Feature Type
  protein coding gene
• IDs
  MGI:1277212
  NCBI Gene: 52397
• Gene Overview
  MyGene.info: ZNF644
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr5:106616739-106697287 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    80549 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 5, 51.43 cM
• Mapping Data
  3 experiments

Homology

• Human Ortholog
  ZNF644, zinc finger protein 644

• Vertebrate Orthologs
  9

• Human Ortholog
  ZNF644, zinc finger protein 644
  Orthology source: HomoloGene, HGNC
• Synonyms
  BM-005, MYP21, NatF, ZEP-2
• Links
  HGNC:29222

  NCBI Gene ID: 84146

  neXtProt AC: NX_Q9H582

  UniProt: Q9H582

  
  
• Chr Location
  1p22.2; chr1:90915298-91022269 (-)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 12971
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: ZNF644
• Gene Tree
  Zfp644
  

Human Diseases

• Diseases
  1 with human ZNF644 associations

				Human Disease	Mouse Models
				myopia IDs myopia       DOID:11830 EFO:0003927 ICD10CM:H52.1 ICD9CM:367.1 MESH:D009216 NCI:C102533 OMIM:160700 OMIM:255500 OMIM:300613 OMIM:310460 OMIM:603221 OMIM:608367 OMIM:608474 OMIM:608908 OMIM:609256 OMIM:609257 OMIM:609258 OMIM:609259 OMIM:609994 OMIM:609995 OMIM:610320 OMIM:612554 OMIM:612717 OMIM:613959 OMIM:613969 OMIM:614166 OMIM:614167 OMIM:615420 OMIM:615431 OMIM:615946 UMLS_CUI:C0027092

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  10 phenotype references
  

• All Mutations and Alleles
  6
• Chemically induced (ENU)
  1
• Chemically induced (other)
  1
• Radiation induced
  1
• Spontaneous
  1
• Targeted
  2
• Genomic Mutations
  3 involving Zfp644
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  52 strains or lines available

Mice homozygous for an ENU-induced allele exhibit normal blood lymphocyte populations.

Gene Ontology
(GO)
Classifications

• External Resources
  FuncBase

Expression

• Assay Results
  8
• Tissues
  8
• cDNA Data
  12
• Literature Summary
  1

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA ZNF644
  ZFIN znf644a, znf644b

Interactions

• Zfp644 interacts with 384 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

Sequences &
Gene Models

• All Sequences
  148
• RefSeq
  58
• UniProt
  14
• CCDS
  CCDS39196.1

• VEGA
  OTTMUSG00000023248 (Evidence)
• Ensembl
  ENSMUSG00000049606 (Evidence)
• NCBI Gene
  52397

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000023248	VEGA Gene Model | MGI Sequence Detail	80549	C57BL/6J
transcript	OTTMUST00000056288	VEGA | MGI Sequence Detail	5785	Not Applicable
polypeptide	OTTMUSP00000027033	VEGA | MGI Sequence Detail	1323	Not Applicable

Polymorphisms

• SNPs within 2kb
  302 from dbSNP Build 142

Protein
Information

• UniProt
  14 Sequences
• InterPro Domains
  IPR013087 Zinc finger C2H2-type
  IPR013083 Zinc finger, RING/FYVE/PHD-type

Molecular
Reagents

• All nucleic 14

  cDNA 12

  Primer pair 2

  
  

  Microarray probesets 6

Other
Accession IDs

MGI:1916116, MGI:2140743

References

• Summaries
  All 35

  Developmental Gene Expression 1

  Phenotypes 10
• Earliest
  J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42