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G6pc2 Gene Detail
Summary
  • Symbol
    G6pc2
  • Name
    glucose-6-phosphatase, catalytic, 2
  • Synonyms
    G6pc-rs, IGRP, islet specific glucose-6-phosphatase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277193
    NCBI Gene: 14378
  • Gene Overview
    MyGene.info: G6PC2
Location & Maps
more
  • Sequence Map
    Chr2:69211073-69227841 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16769 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 39.66 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    G6PC2, glucose-6-phosphatase catalytic subunit 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    G6PC2, glucose-6-phosphatase catalytic subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IGRP
  • Links
    NCBI Gene ID: 57818
    neXtProt AC: NX_Q9NQR9

  • Chr Location
    2q31.1; chr2:168901240-168910000 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with G6pc2 mouse models

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Targeted
    5
  • Transgenic
    4
  • Genomic Mutations
    1 involving G6pc2
  • Incidental Mutations
Mice homozygous for a disruption of this gene show a significant drop in fasting blood glucose. Females also show a significant drop in plasma triacylglycerol.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012981 VEGA Gene Model | MGI Sequence Detail 16769 C57BL/6J ±  kb
transcript OTTMUST00000031263 VEGA | MGI Sequence Detail 1892 Not Applicable  
polypeptide OTTMUSP00000013987 VEGA | MGI Sequence Detail 355 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    125 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 7
    Primer pair 2
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Developmental Gene Expression 5
    Diseases 2
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:64688 Arden SD, et al., Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein. Diabetes. 1999 Mar;48(3):531-42
  • Latest
    J:229667 Clemente-Casares X, et al., Expanding antigen-specific regulatory networks to treat autoimmunity. Nature. 2016 Feb 25;530(7591):434-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory