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Pde9a Gene Detail
Summary
  • Symbol
    Pde9a
  • Name
    phosphodiesterase 9A
  • Synonyms
    PDE9A1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277179
    NCBI Gene: 18585
  • Gene Overview
    MyGene.info: PDE9A
Location & Maps
more
  • Sequence Map
    Chr17:31386234-31476310 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      90077 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 16.23 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PDE9A, phosphodiesterase 9A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDE9A, phosphodiesterase 9A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSPDE9A2
  • Links
    NCBI Gene ID: 5152
    neXtProt AC: NX_O76083

  • Chr Location
    21q22.3; chr21:42653752-42775520 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 113565
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: PDE9A
  • Gene Tree
Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Gene trapped
    19
  • Targeted
    7
  • Genomic Mutations
    4 involving Pde9a
  • Incidental Mutations
Mice homozygous for a null allele exhibit suppressed pressure-overload-induced cardiac pathobiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033902 VEGA Gene Model | MGI Sequence Detail 90077 C57BL/6J ±  kb
transcript OTTMUST00000085511 VEGA | MGI Sequence Detail 1891 Not Applicable  
polypeptide OTTMUSP00000046197 VEGA | MGI Sequence Detail 534 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    457 from dbSNP Build 142
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000012488 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
  • EC
  • InterPro Domains
    IPR023088 3'5'-cyclic nucleotide phosphodiesterase
    IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
    IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
    IPR003607 HD/PDEase domain
Molecular
Reagents
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  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 5
    Diseases 2
    Gene Ontology 7
    Phenotypes 14
  • Earliest
    J:48139 Soderling SH, et al., Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J Biol Chem. 1998 Jun 19;273(25):15553-8
  • Latest
    J:220465 Lee DI, et al., Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease. Nature. 2015 Mar 26;519(7544):472-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory