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Arhgef25 Gene Detail
Summary
  • Symbol
    Arhgef25
  • Name
    Rho guanine nucleotide exchange factor (GEF) 25
  • Synonyms
    2410008H17Rik, D10Ertd610e, GEFT
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277173
    NCBI Gene: 52666
  • Gene Overview
    MyGene.info: ARHGEF25
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127182525-127190083 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 74.50 cM, cytoband D3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    37 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277173
protein coding gene Chr10:127182521-127190085 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017810
protein coding gene Chr10:130763910-130771447 (-)
A/J MGP_AJ_G0017785
protein coding gene Chr10:125527700-125535233 (-)
AKR/J MGP_AKRJ_G0017748
protein coding gene Chr10:129242537-129250074 (-)
BALB/cJ MGP_BALBcJ_G0017749
protein coding gene Chr10:125938323-125945859 (-)
C3H/HeJ MGP_C3HHeJ_G0017573
protein coding gene Chr10:129383997-129391528 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018204
protein coding gene Chr10:135200513-135208150 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015884
protein coding gene Chr10:119535785-119543359 (-)
CAST/EiJ MGP_CASTEiJ_G0017133
protein coding gene Chr10:130039717-130047254 (-)
CBA/J MGP_CBAJ_G0017542
protein coding gene Chr10:140639922-140647453 (-)
DBA/2J MGP_DBA2J_G0017648
protein coding gene Chr10:124620658-124628195 (-)
FVB/NJ MGP_FVBNJ_G0017643
protein coding gene Chr10:123560398-123567935 (-)
LP/J MGP_LPJ_G0017722
protein coding gene Chr10:131336381-131343917 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017671
protein coding gene Chr10:143352027-143359564 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018244
protein coding gene Chr10:129302666-129310203 (-)
PWK/PhJ MGP_PWKPhJ_G0016918
protein coding gene Chr10:124816537-124824074 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016710
protein coding gene Chr10:128338147-128345668 (-)
WSB/EiJ MGP_WSBEiJ_G0017194
protein coding gene Chr10:129528940-129536474 (-)



Homology
more
  • Human Ortholog
    ARHGEF25, Rho guanine nucleotide exchange factor 25
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ARHGEF25, Rho guanine nucleotide exchange factor 25
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GEFT, p63RhoGEF
  • Links
    NCBI Gene ID: 115557
    neXtProt AC: NX_Q86VW2
    UniProt: Q86VW2

  • Chr Location
    12q13.3; chr12:57610180-57617245 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Mice homozygous for a conditional allele activated in the second heart field exhibit normal cardiac development and prenatal survival.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019467 Ensembl Gene Model | MGI Sequence Detail 7559 C57BL/6J ±  kb
transcript ENSMUST00000019611 Ensembl | MGI Sequence Detail 2218 Not Applicable  
polypeptide ENSMUSP00000019611 Ensembl | MGI Sequence Detail 618 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    9 Sequences
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR035899 Dbl homology (DH) domain superfamily
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR030738 Rho guanine nucleotide exchange factor 25
Molecular
Reagents
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  • All nucleic 76
    cDNA 73
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
less
MGI:1919219
References
more
  • Summaries
    All 38
    Developmental Gene Expression 8
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:251386 Ongherth A, et al., p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts. J Mol Cell Cardiol. 2015 Nov;88:39-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory