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Vax1 Gene Detail
Summary
  • Symbol
    Vax1
  • Name
    ventral anterior homeobox 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277163
    NCBI Gene: 22326
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:59154619-59158488 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 54.61 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    7 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277163
 protein coding gene Chr19:59152912-59158829 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025285
 protein coding gene Chr19:59676018-59679887 (-)
A/J MGP_AJ_G0025261
 protein coding gene Chr19:56760617-56764486 (-)
AKR/J MGP_AKRJ_G0025230
 protein coding gene Chr19:58526314-58530183 (-)
BALB/cJ MGP_BALBcJ_G0025256
 protein coding gene Chr19:56830251-56834120 (-)
C3H/HeJ MGP_C3HHeJ_G0025016
 protein coding gene Chr19:58780570-58784439 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025699
 protein coding gene Chr19:61120029-61123898 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023111
 protein coding gene Chr19:55641670-55645545 (-)
CAST/EiJ MGP_CASTEiJ_G0024481
 protein coding gene Chr19:58869911-58873780 (-)
CBA/J MGP_CBAJ_G0024996
 protein coding gene Chr19:64101704-64105573 (-)
DBA/2J MGP_DBA2J_G0025128
 protein coding gene Chr19:56503182-56507051 (-)
FVB/NJ MGP_FVBNJ_G0025089
 protein coding gene Chr19:56250595-56254464 (-)
LP/J MGP_LPJ_G0025214
 protein coding gene Chr19:59557115-59560984 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025122
 protein coding gene Chr19:63323504-63327373 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025757
 protein coding gene Chr19:58761619-58765448 (-)
PWK/PhJ MGP_PWKPhJ_G0024229
 protein coding gene Chr19:56525669-56529496 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024032
 protein coding gene Chr19:57423905-57427768 (-)
WSB/EiJ MGP_WSBEiJ_G0024551
 protein coding gene Chr19:58882130-58885998 (-)



Homology
more
  • Human Ortholog
    VAX1, ventral anterior homeobox 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VAX1, ventral anterior homeobox 1
  • Synonyms
    MCOPS11
  • Links
    NCBI Gene ID: 11023
    neXtProt AC: NX_Q5SQQ9
    UniProt: Q5SQQ9

  • Chr Location
    10q25.3; chr10:117128520-117138301 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human VAX1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 3 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit cleft palate and most die at birth. A few survive to 2 weeks of age. Mutants display defects in axon guidance, coloboma, dysgenesis of the optic nerve, defects of basal telencephalon, and holoprosencephaly.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1030
  • Tissues
    228
  • cDNA Data
    11
  • Literature Summary
    58
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006270 Ensembl Gene Model | MGI Sequence Detail 3870 C57BL/6J ±  kb
    transcript ENSMUST00000172821 Ensembl | MGI Sequence Detail 1044 Not Applicable  
    polypeptide ENSMUSP00000134642 Ensembl | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 13
      Primer pair 1
      Other 8

      Microarray probesets 2
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 58
      Gene Ontology 9
      Phenotypes 21
    • Earliest
      J:49133 Hallonet M, et al., Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain. Development. 1998 Jul;125(14):2599-610
    • Latest
      J:341148 Bosze B, et al., Notch pathway mutants do not equivalently perturb mouse embryonic retinal development. PLoS Genet. 2023 Sep;19(9):e1010928
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory