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Vax1
Gene Detail
Symbol

Name
ID
Vax1
ventral anterior homeobox 1
MGI:1277163
Feature Type
protein coding gene
Genetic Map
Chromosome 19
54.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:59166187-59170056 bp, - strand
From VEGA annotation of GRCm38

  3870 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7593  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: VAX1
Gene Tree: Vax1

Human
homologs
VAX1, ventral anterior homeobox 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 11023
neXtProt AC: NX_Q5SQQ9

Human Synonyms: MCOPS11

Human Chr (Location): 10q26.1; chr10:117128521-117138301 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human VAX1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Homozygous null mutants exhibit cleft palate and most die at birth. A few survive to 2 weeks of age. Mutants display defects in axon guidance, coloboma, dysgenesis of the optic nerve, defects of basal telencephalon, and holoprosencephaly.
 
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process axon guidance, brain development, ...
Component nucleus
Function chromatin DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (218)    Tissues (187)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 218
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA VAX1 ZFIN vax1    NEW 
Molecular
reagents
All nucleic(15) cDNA(11) Primer pair(1) Other(3)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000037558 (Evidence)
Ensembl Gene Model ENSMUSG00000006270 (Evidence)
Entrez Gene 22326 (Evidence)
UniGene 23801
DFCI TC1692908
DoTS DT.87032698, DT.110882758
NIA Mouse Gene Index U039191
Consensus CDS Project CCDS29933.1
International Mouse Phenotyping Consortium Status Vax1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037558 VEGA Gene Model | MGI Sequence Detail 3870 C57BL/6J ±  kb
transcript OTTMUST00000096822 VEGA | MGI Sequence Detail 1044 Not Applicable 
polypeptide OTTMUSP00000054141 VEGA | MGI Sequence Detail 338 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000017268 ventral anterior homeobox 1
References
(Earliest) J:49133 Hallonet M, et al., Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain. Development. 1998 Jul;125(14):2599-610
(Latest) J:218337 Hoffmann HM, et al., Heterozygous deletion of ventral anterior homeobox (vax1) causes subfertility in mice. Endocrinology. 2014 Oct;155(10):4043-53
All references(65)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory