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Vax1 Gene Detail
Summary
  • Symbol
    Vax1
  • Name
    ventral anterior homeobox 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277163
    NCBI Gene: 22326
  • Gene Overview
    MyGene.info: VAX1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:59166187-59170056 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 54.61 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    7 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277163
protein coding gene Chr19:59164480-59170056 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025285
protein coding gene Chr19:59676018-59679887 (-)
A/J MGP_AJ_G0025261
protein coding gene Chr19:56760617-56764486 (-)
AKR/J MGP_AKRJ_G0025230
protein coding gene Chr19:58526314-58530183 (-)
BALB/cJ MGP_BALBcJ_G0025256
protein coding gene Chr19:56830251-56834120 (-)
C3H/HeJ MGP_C3HHeJ_G0025016
protein coding gene Chr19:58780570-58784439 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025699
protein coding gene Chr19:61120029-61123898 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023111
protein coding gene Chr19:55641670-55645545 (-)
CAST/EiJ MGP_CASTEiJ_G0024481
protein coding gene Chr19:58869911-58873780 (-)
CBA/J MGP_CBAJ_G0024996
protein coding gene Chr19:64101704-64105573 (-)
DBA/2J MGP_DBA2J_G0025128
protein coding gene Chr19:56503182-56507051 (-)
FVB/NJ MGP_FVBNJ_G0025089
protein coding gene Chr19:56250595-56254464 (-)
LP/J MGP_LPJ_G0025214
protein coding gene Chr19:59557115-59560984 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025122
protein coding gene Chr19:63323504-63327373 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025757
protein coding gene Chr19:58761619-58765448 (-)
PWK/PhJ MGP_PWKPhJ_G0024229
protein coding gene Chr19:56525669-56529496 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024032
protein coding gene Chr19:57423905-57427768 (-)
WSB/EiJ MGP_WSBEiJ_G0024551
protein coding gene Chr19:58882130-58885998 (-)



Homology
more
  • Human Ortholog
    VAX1, ventral anterior homeobox 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    VAX1, ventral anterior homeobox 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MCOPS11
  • Links
    NCBI Gene ID: 11023
    neXtProt AC: NX_Q5SQQ9
    UniProt: Q5SQQ9

  • Chr Location
    10q25.3; chr10:117128521-117138301 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7593
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: VAX1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit cleft palate and most die at birth. A few survive to 2 weeks of age. Mutants display defects in axon guidance, coloboma, dysgenesis of the optic nerve, defects of basal telencephalon, and holoprosencephaly.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006270 Ensembl Gene Model | MGI Sequence Detail 3870 C57BL/6J ±  kb
    transcript ENSMUST00000172821 Ensembl | MGI Sequence Detail 1044 Not Applicable  
    polypeptide ENSMUSP00000134642 Ensembl | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 12
      Primer pair 1
      Other 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 47
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:49133 Hallonet M, et al., Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain. Development. 1998 Jul;125(14):2599-610
    • Latest
      J:264268 Li J, et al., Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development. Cereb Cortex. 2018 Sep 1;28(9):3278-3294

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory