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Gtf2h3 Gene Detail
Summary
  • Symbol
    Gtf2h3
  • Name
    general transcription factor IIH, polypeptide 3
  • Synonyms
    34kDa, 5033417D07Rik, BTF2, D5Ertd679e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277143
    NCBI Gene: 209357
Location & Maps
more
  • Sequence Map
    Chr5:124579140-124597680 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18541 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 63.67 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GTF2H3, general transcription factor IIH subunit 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GTF2H3, general transcription factor IIH subunit 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BTF2, P34, TFB4, TFIIH
  • Links
    NCBI Gene ID: 2967
    neXtProt AC: NX_Q13889

  • Chr Location
    12q24.31; chr12:123633739-123662604 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    22
  • Chemically induced (other)
    1
  • Gene trapped
    18
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Gtf2h3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024483 VEGA Gene Model | MGI Sequence Detail 18541 C57BL/6J ±  kb
transcript OTTMUST00000060068 VEGA | MGI Sequence Detail 2672 Not Applicable  
polypeptide OTTMUSP00000029280 VEGA | MGI Sequence Detail 309 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    166 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008319 general transcription factor IIH subunit 3
  • InterPro Domains
    IPR004600 TFIIH subunit Tfb4/p34
Molecular
Reagents
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  • All nucleic 58
    cDNA 55
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGI:1923218
References
more
  • Summaries
    All 38
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:181994 Kamileri I, et al., Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory