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Pde8a Gene Detail
Summary
  • Symbol
    Pde8a
  • Name
    phosphodiesterase 8A
  • Synonyms
    Pde8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277116
    NCBI Gene: 18584
  • Gene Overview
    MyGene.info: PDE8A
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:81213804-81333622 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.71 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    577 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277116
protein coding gene Chr7:81213596-81334533 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032426
protein coding gene Chr7:83253560-83390524 (+)
A/J MGP_AJ_G0032405
protein coding gene Chr7:81294281-81421826 (+)
AKR/J MGP_AKRJ_G0032341
protein coding gene Chr7:83091173-83228518 (+)
BALB/cJ MGP_BALBcJ_G0032417
protein coding gene Chr7:80957250-81082450 (+)
C3H/HeJ MGP_C3HHeJ_G0032130
protein coding gene Chr7:83706097-83837269 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032909
protein coding gene Chr7:86521120-86657819 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029917
protein coding gene Chr7:83783736-83906381 (+)
CAST/EiJ MGP_CASTEiJ_G0031458
protein coding gene Chr7:74626505-74772384 (+)
CBA/J MGP_CBAJ_G0032096
protein coding gene Chr7:89422754-89561511 (+)
DBA/2J MGP_DBA2J_G0032251
protein coding gene Chr7:79831652-79953025 (+)
FVB/NJ MGP_FVBNJ_G0032206
protein coding gene Chr7:79760909-79886633 (+)
LP/J MGP_LPJ_G0032332
protein coding gene Chr7:84489571-84621698 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032243
protein coding gene Chr7:89496283-89627220 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032927
protein coding gene Chr7:82500930-82631205 (+)
PWK/PhJ MGP_PWKPhJ_G0031178
protein coding gene Chr7:73042470-73166699 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031019
protein coding gene Chr7:69509812-69643839 (+)
WSB/EiJ MGP_WSBEiJ_G0031576
protein coding gene Chr7:82865457-82996618 (+)



Homology
more
  • Human Ortholog
    PDE8A, phosphodiesterase 8A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDE8A, phosphodiesterase 8A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HsT19550
  • Links
    NCBI Gene ID: 5151
    neXtProt AC: NX_O60658
    UniProt: O60658

  • Chr Location
    15q25.3; chr15:84980513-85139145 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted disruption of this gene results in a 4-fold increase in basal release of testosterone in isolated Leydig cells as well as a significant increase in the sensitivity to luteinizing hormone, measured as testosterone released into the media.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18584 NCBI Gene Model | MGI Sequence Detail 119819 C57BL/6J ±  kb
    transcript NM_008803 RefSeq | MGI Sequence Detail 4135 Not Specified  
    polypeptide O88502 UniProt | EBI | MGI Sequence Detail 823 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 47
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141996
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 22
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory