Targeted disruption of this gene results in a 4-fold increase in basal release of testosterone in isolated Leydig cells as well as a significant increase in the sensitivity to luteinizing hormone, measured as testosterone released into the media.
|InterPro||IPR023088||3'5'-cyclic nucleotide phosphodiesterase|
|InterPro||IPR002073||3'5'-cyclic nucleotide phosphodiesterase, catalytic domain|
|InterPro||IPR023174||3'5'-cyclic nucleotide phosphodiesterase, conserved site|
|InterPro||IPR001789||Signal transduction response regulator, receiver domain|
|Protein Ontology||PR:000012486||high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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