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Pde8a Gene Detail
Summary
  • Symbol
    Pde8a
  • Name
    phosphodiesterase 8A
  • Synonyms
    Pde8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277116
    NCBI Gene: 18584
Location & Maps
more
  • Sequence Map
    Chr7:81213596-81334533 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      120938 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PDE8A, phosphodiesterase 8A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PDE8A, phosphodiesterase 8A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HsT19550
  • Links
    NCBI Gene ID: 5151
    neXtProt AC: NX_O60658

  • Chr Location
    15q25.3; chr15:84980513-85139145 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Pde8a
  • Incidental Mutations
Targeted disruption of this gene results in a 4-fold increase in basal release of testosterone in isolated Leydig cells as well as a significant increase in the sensitivity to luteinizing hormone, measured as testosterone released into the media.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024583 VEGA Gene Model | MGI Sequence Detail 120938 C57BL/6J ±  kb
transcript OTTMUST00000060395 VEGA | MGI Sequence Detail 3802 Not Applicable  
polypeptide OTTMUSP00000029460 VEGA | MGI Sequence Detail 823 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    585 from dbSNP Build 137
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012486 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
  • EC
  • InterPro Domains
    IPR023088 3'5'-cyclic nucleotide phosphodiesterase
    IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
    IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
    IPR011006 CheY-like superfamily
    IPR003607 HD/PDEase domain
    IPR000014 PAS domain
    IPR013767 PAS fold
Molecular
Reagents
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  • All nucleic 48
    cDNA 46
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGI:2141996
References
more
  • Summaries
    All 37
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 20
  • Earliest
    J:48936 Soderling SH, et al., Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8991-6
  • Latest
    J:195529 Brown KM, et al., Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):E1533-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory