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Pde8a
Gene Detail
Symbol

Name
ID
Pde8a
phosphodiesterase 8A
MGI:1277116
Synonyms
Pde8
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:81213596-81334533 bp, + strand
From VEGA annotation of GRCm38

  120938 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1957  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 3',5'-cyclic-nucleotide phosphodiesterase 8A, high affinity cAMP-specific
Gene Tree: Pde8a

Human
homologs
Human Homolog PDE8A, phosphodiesterase 8A
NCBI Gene ID 5151
neXtProt AC  NX_O60658
Human Synonyms  HsT19550
Human Chr (Location)  15q25.3; chr15:84980513-85139145 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted disruption of this gene results in a 4-fold increase in basal release of testosterone in isolated Leydig cells as well as a significant increase in the sensitivity to luteinizing hormone, measured as testosterone released into the media.
 
Interactions
Pde8a interacts with 153 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (152)    Tissues (115)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 150
RT-PCR 2
cDNA source data(45)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(46) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024583 (Evidence)
Ensembl Gene ModelENSMUSG00000025584 (Evidence)
Entrez Gene18584 (Evidence)
UniGene371577
DFCITC1581017
DoTSDT.486127
NIA Mouse Gene IndexU142803
EC3.1.4.53
Consensus CDS ProjectCCDS40005.1
International Mouse Knockout Project StatusPde8a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024583 VEGA Gene Model | MGI Sequence Detail 120938 C57BL/6J ±  kb
transcript OTTMUST00000060395 VEGA | MGI Sequence Detail 3802 Not Applicable 
polypeptide OTTMUSP00000029460 VEGA | MGI Sequence Detail 823 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(585 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023088 3'5'-cyclic nucleotide phosphodiesterase
InterPro IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
InterPro IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro IPR011006 CheY-like superfamily
InterPro IPR003607 HD/PDEase domain
InterPro IPR000014 PAS domain
InterPro IPR001789 Signal transduction response regulator, receiver domain
Protein Ontology PR:000012486 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
References
(Earliest) J:48936 Soderling SH, et al., Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8991-6
(Latest) J:195529 Brown KM, et al., Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):E1533-42
All references(41)
Other
accession IDs
MGI:2141996

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory