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Pacs1
Gene Detail
Symbol

Name
ID
Pacs1
phosphofurin acidic cluster sorting protein 1
MGI:1277113
Synonyms
MGC:37046
Feature Type
protein coding gene
Genetic Map
Chromosome 19
4.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:5133688-5273119 bp, - strand
From Ensembl annotation of GRCm38

  139432 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9970  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pacs1

Human
homologs
Human Homolog PACS1, phosphofurin acidic cluster sorting protein 1
NCBI Gene ID 55690
neXtProt AC  NX_Q6VY07
Human Synonyms  MRD17
Human Chr (Location)  11q13.1-q13.2; chr11:66070276-66244747 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PACS1
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(19) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pacs1 interacts with 191 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cellular protein localization, positive regulation of protein binding, ...
Component COPI-coated vesicle, Golgi apparatus, ...
Function ion channel binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (70)    Tissues (8)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 70
cDNA source data(102)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(102) cDNA(102)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024855 (Evidence)
Entrez Gene107975 (Evidence)
UniGene234923
DFCITC1576590
DoTSDT.110878066, DT.496345, DT.97410403
NIA Mouse Gene IndexU019063
Consensus CDS ProjectCCDS29453.1
International Mouse Knockout Project StatusPacs1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024855 Ensembl Gene Model | MGI Sequence Detail 139432 C57BL/6J ±  kb
transcript ENSMUST00000025786 Ensembl | MGI Sequence Detail 4339 Not Applicable 
polypeptide ENSMUSP00000025786 Ensembl | MGI Sequence Detail 961 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(598 from dbSNP Build 137)    SNPs within 2kb including multiple locations(600)
Protein-related
information
ResourceIDDescription
InterPro IPR019381 Phosphofurin acidic cluster sorting protein 1
Protein Ontology PR:000012215 phosphofurin acidic cluster sorting protein 1
References
(Earliest) J:48829 Wan L, et al., PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization. Cell. 1998 Jul 24;94(2):205-16
(Latest) J:205418 Burgert T, et al., SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes. Mol Cell Biol. 2013 Nov;33(21):4308-20
All references(34)
Other
accession IDs
MGI:2147510

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory