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Pacs1 Gene Detail
Summary
  • Symbol
    Pacs1
  • Name
    phosphofurin acidic cluster sorting protein 1
  • Synonyms
    MGC:37046
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277113
    NCBI Gene: 107975
  • Gene Overview
    MyGene.info: PACS1
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5183710-5323327 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.25 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    580 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277113
 protein coding gene Chr19:5183186-5323327 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024695
 protein coding gene Chr19:2068302-2224508 (-)
A/J MGP_AJ_G0024661
 protein coding gene Chr19:1960693-2101357 (-)
AKR/J MGP_AKRJ_G0024634
 protein coding gene Chr19:2010323-2165782 (-)
BALB/cJ MGP_BALBcJ_G0024661
 protein coding gene Chr19:1958458-2101865 (-)
C3H/HeJ MGP_C3HHeJ_G0024429
 protein coding gene Chr19:2011627-2169598 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025108
 protein coding gene Chr19:2122143-2278523 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022538
 protein coding gene Chr19:1886467-2013462 (-)
CAST/EiJ MGP_CASTEiJ_G0023901
 protein coding gene Chr19:2042414-2192237 (-)
CBA/J MGP_CBAJ_G0024401
 protein coding gene Chr19:2207863-2375208 (-)
DBA/2J MGP_DBA2J_G0024528
 protein coding gene Chr19:1944300-2084720 (-)
FVB/NJ MGP_FVBNJ_G0024495
 protein coding gene Chr19:1946135-2089042 (-)
LP/J MGP_LPJ_G0024614
 protein coding gene Chr19:2059257-2203095 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024525
 protein coding gene Chr19:2082660-2234682 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025156
 protein coding gene Chr19:2012317-2165935 (-)
PWK/PhJ MGP_PWKPhJ_G0023647
 protein coding gene Chr19:1982207-2122976 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023452
 protein coding gene Chr19:2002306-2154604 (-)
WSB/EiJ MGP_WSBEiJ_G0023963
 protein coding gene Chr19:2023435-2179260 (-)



Homology
more
  • Human Ortholog
    PACS1, phosphofurin acidic cluster sorting protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PACS1, phosphofurin acidic cluster sorting protein 1
  • Synonyms
    MRD17, SHMS
  • Links
    NCBI Gene ID: 55690
    neXtProt AC: NX_Q6VY07
    UniProt: Q6VY07

  • Chr Location
    11q13.1-q13.2; chr11:66070276-66244747 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human PACS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    8
  • cDNA Data
    103
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107975 NCBI Gene Model | MGI Sequence Detail 139618 C57BL/6J ±  kb
    transcript NM_153129 RefSeq | MGI Sequence Detail 4360 C57BL/6  
    polypeptide Q8K212 UniProt | EBI | MGI Sequence Detail 961 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 103
      cDNA 103

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147510
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:48829 Wan L, et al., PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization. Cell. 1998 Jul 24;94(2):205-16
    • Latest
      J:205418 Burgert T, et al., SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes. Mol Cell Biol. 2013 Nov;33(21):4308-20
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/05/2021
    MGI 6.17     		The Jackson Laboratory