Pacs1
Gene Detail

Symbol

Name
ID

Pacs1
phosphofurin acidic cluster sorting protein 1
MGI:1277113

Synonyms

MGC:37046

Feature Type

protein coding gene

Genetic Map

Chromosome 19
4.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr19:5133688-5273119 bp, - strand From Ensembl annotation of GRCm38   139432 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:9970  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pacs1

Human
homologs

Human Homolog		PACS1, phosphofurin acidic cluster sorting protein 1
NCBI Gene ID		55690
neXtProt AC		NX_Q6VY07
Human Synonyms		MRD17
Human Chr (Location)		11q13.1-q13.2; chr11:66070276-66244747 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human PACS1

Mutations,
alleles, and
phenotypes

All mutations/alleles(20) : Gene trapped(19) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Pacs1 interacts with 191 markers (Mir1b, Mir7-1, Mir7-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (8 annotations)

Process	cellular protein localization, positive regulation of protein binding, ...
Component	COPI-coated vesicle, Golgi apparatus, ...
Function	ion channel binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (70)    Tissues (8)    Images (24)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	70

cDNA source data(102)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(102) cDNA(102)
Microarray probesets(3)

Other database
links

Ensembl Gene Model	ENSMUSG00000024855 (Evidence)
Entrez Gene	107975 (Evidence)
UniGene	234923
DFCI	TC1576590
DoTS	DT.110878066, DT.97410403, DT.496345
NIA Mouse Gene Index	U019063
Consensus CDS Project	CCDS29453.1
International Mouse Knockout Project Status	Pacs1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000024855	Ensembl Gene Model | MGI Sequence Detail	139432	C57BL/6J
transcript	ENSMUST00000025786	Ensembl | MGI Sequence Detail	4339	Not Applicable
polypeptide	ENSMUSP00000025786	Ensembl | MGI Sequence Detail	961	Not Applicable

All sequences(34) RefSeq(2) UniProt(5)

Polymorphisms

SNPs within 2kb(598 from dbSNP Build 137)    SNPs within 2kb including multiple locations(600)

Protein-related
information

Resource	ID	Description
InterPro	IPR019381	Phosphofurin acidic cluster sorting protein 1
Protein Ontology	PR:000012215	phosphofurin acidic cluster sorting protein 1

References

(Earliest) J:48829 Wan L, et al., PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization. Cell. 1998 Jul 24;94(2):205-16
(Latest) J:205418 Burgert T, et al., SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes. Mol Cell Biol. 2013 Nov;33(21):4308-20
All references(34)

Other
accession IDs

MGI:2147510