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Pacs1
Gene Detail
Symbol

Name
ID
Pacs1
phosphofurin acidic cluster sorting protein 1
MGI:1277113
Synonyms
MGC:37046
Feature Type
protein coding gene
Genetic Map
Chromosome 19
4.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:5133688-5273119 bp, - strand
From Ensembl annotation of GRCm38

  139432 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9970  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PACS1
Gene Tree: Pacs1

Human
homologs
PACS1, phosphofurin acidic cluster sorting protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 55690
neXtProt AC: NX_Q6VY07

Human Synonyms: MRD17

Human Chr (Location): 11q13.1-q13.2; chr11:66070353-66244747 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PACS1

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(19) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pacs1 interacts with 190 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cellular protein localization, positive regulation of protein binding, ...
Component COPI-coated vesicle, Golgi apparatus, ...
Function ion channel binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (70)    Tissues (8)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 70
cDNA source data(102)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pacs1 ; ZFIN pacs1a    NEW 
Molecular
reagents
All nucleic(102) cDNA(102)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000024855 (Evidence)
Entrez Gene 107975 (Evidence)
UniGene 234923
DFCI TC1576590
DoTS DT.110878066, DT.97410403, DT.496345
NIA Mouse Gene Index U019063
Consensus CDS Project CCDS29453.1
International Mouse Phenotyping Consortium Status Pacs1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024855 Ensembl Gene Model | MGI Sequence Detail 139432 C57BL/6J ±  kb
transcript ENSMUST00000025786 Ensembl | MGI Sequence Detail 4339 Not Applicable 
polypeptide ENSMUSP00000025786 Ensembl | MGI Sequence Detail 961 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(598 from dbSNP Build 137)    SNPs within 2kb including multiple locations(600)
Protein-related
information
ResourceIDDescription
InterPro IPR019381 Phosphofurin acidic cluster sorting protein 1
Protein Ontology PR:000012215 phosphofurin acidic cluster sorting protein 1
References
(Earliest) J:48829 Wan L, et al., PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization. Cell. 1998 Jul 24;94(2):205-16
(Latest) J:205418 Burgert T, et al., SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes. Mol Cell Biol. 2013 Nov;33(21):4308-20
All references(33)
Other
accession IDs
MGI:2147510

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory