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Ptp4a3 Gene Detail
Summary
  • Symbol
    Ptp4a3
  • Name
    protein tyrosine phosphatase 4a3
  • Synonyms
    Prl-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277098
    NCBI Gene: 19245
  • Gene Overview
    MyGene.info: PTP4A3
Location & Maps
more
  • Sequence Map
    Chr15:73723145-73758766 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      35622 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 34.05 cM, cytoband E1
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PTP4A3, protein tyrosine phosphatase type IVA, member 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTP4A3, protein tyrosine phosphatase type IVA, member 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PRL3, PRL-3, PRL-R
  • Links
    NCBI Gene ID: 11156
    neXtProt AC: NX_O75365

  • Chr Location
    8q24.3; chr8:141391993-141432454 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    3
  • Gene trapped
    9
  • Radiation induced
    2
  • Targeted
    6
  • Genomic Mutations
    5 involving Ptp4a3
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit partial preweaning lethality and decreased incidence of AOM-DDS induced tumors. Mice homozygous for a different targeted allele exhibit decreased circulating glucose levels in an intraperitoneal glucose tolerance test.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19245 NCBI Gene Model | MGI Sequence Detail 35622 C57BL/6J ±  kb
transcript NM_001166388 RefSeq | MGI Sequence Detail 3808 C57BL/6  
polypeptide Q9D658 UniProt | EBI | MGI Sequence Detail 173 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    421 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013442 protein tyrosine phosphatase type IVA 3
  • EC
  • InterPro Domains
    IPR000340 Dual specificity phosphatase, catalytic domain
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
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  • All nucleic 94
    cDNA 94

    Microarray probesets 4
Other
Accession IDs
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MGI:2146167
References
more
  • Summaries
    All 38
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 5
    Phenotypes 31
  • Earliest
    J:46627 Zeng Q, et al., Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1. Biochem Biophys Res Commun. 1998 Mar 17;244(2):421-7
  • Latest
    J:209508 Zimmerman MW, et al., Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility. J Biol Chem. 2014 Feb 28;289(9):5904-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory