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Alx3
Gene Detail
 Symbol
Name
ID
Alx3
aristaless-like homeobox 3
MGI:1277097
Feature Type protein coding gene
Genetic Map
Chromosome 3
46.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:107595031-107605776 bp, + strand
From VEGA annotation of GRCm38

  10746 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4737  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Alx3

Human
homologs
Human Homolog ALX3, ALX homeobox 3
NCBI Gene ID 257
neXtProt AC  NX_O95076
Human Synonyms  FND, FND1
Human Chr (Location)  1p13.3; chr1:110060375-110070700 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ALX3
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in defects in glucose metabolism. Mice homozygous for a reporter allele exhibit partial preweaning lethality, open neural tube and craniofacial defects in some mice.
 
Interactions
Alx3 interacts with 72 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process embryonic forelimb morphogenesis, embryonic hindlimb morphogenesis, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (446)    Tissues (267)    Images (98)
Theiler Stages: 10, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 27, 28
Assay TypeResults
RNA in situ 429
In situ reporter (knock in) 5
Northern blot 6
RT-PCR 6
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(7) Primer pair(3) Other(5)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000035928 (Evidence)
Ensembl Gene ModelENSMUSG00000014603 (Evidence)
Entrez Gene11694 (Evidence)
UniGene10112
DFCITC1591518
DoTSDT.55132945
Consensus CDS ProjectCCDS17739.1
International Mouse Knockout Project StatusAlx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035928 VEGA Gene Model | MGI Sequence Detail 10746 C57BL/6J ±  kb
transcript OTTMUST00000092161 VEGA | MGI Sequence Detail 1874 Not Applicable 
polypeptide OTTMUSP00000050872 VEGA | MGI Sequence Detail 343 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000003979 homeobox protein aristaless-like 3
References (Earliest) J:48587 ten Berge D, et al., Mouse Alx3: an aristaless-like homeobox gene expressed during embryogenesis in ectomesenchyme and lateral plate mesoderm. Dev Biol. 1998 Jul 1;199(1):11-25
(Latest) J:202450 He F, et al., A Critical Role for PDGFRalpha Signaling in Medial Nasal Process Development. PLoS Genet. 2013 Sep;9(9):e1003851
All references(53)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory