About   Help   FAQ
Ptp4a1 Gene Detail
Summary
  • Symbol
    Ptp4a1
  • Name
    protein tyrosine phosphatase 4a1
  • Synonyms
    Prl-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277096
    NCBI Gene: 19243
  • Gene Overview
    MyGene.info: PTP4A1
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr1:30940302-30949770 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 11.47 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277096
protein coding gene Chr1:30940302-30950181 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015896
protein coding gene Chr1:29149508-29163239 (-)
A/J MGP_AJ_G0015878
protein coding gene Chr1:28451075-28459595 (-)
AKR/J MGP_AKRJ_G0015834
protein coding gene Chr1:28762791-28772299 (-)
BALB/cJ MGP_BALBcJ_G0015833
protein coding gene Chr1:28195492-28205733 (-)
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0014006
protein coding gene Chr1:25981602-25991213 (-)
CAST/EiJ MGP_CASTEiJ_G0015246
protein coding gene Chr1:28855567-28865039 (-)
CBA/J MGP_CBAJ_G0015639
protein coding gene Chr1:31294031-31309938 (-)
DBA/2J MGP_DBA2J_G0015739
protein coding gene Chr1:27899430-27908801 (-)
FVB/NJ MGP_FVBNJ_G0015742
protein coding gene Chr1:27460684-27475254 (-)
LP/J MGP_LPJ_G0015810
protein coding gene Chr1:29447782-29455993 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015762
protein coding gene Chr1:33391120-33402566 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016334
protein coding gene Chr1:28738964-28749370 (-)
PWK/PhJ MGP_PWKPhJ_G0015029
protein coding gene Chr1:27562239-27571951 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0015310
protein coding gene Chr1:28693448-28703463 (-)



Homology
more
  • Human Ortholog
    PTP4A1, protein tyrosine phosphatase type IVA, member 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PTP4A1, protein tyrosine phosphatase type IVA, member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HH72, PRL1, PRL-1, PTPCAAX1, PTP(CAAX1)
  • Links
    NCBI Gene ID: 7803
    neXtProt AC: NX_Q93096
    UniProt: Q93096

  • Chr Location
    6q12; chr6:63528021-63583588 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    16 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
A homozygous null mutation leads to an increase in preweaning lethality. Homozygous KO in combination with homozygous KO of Ptp4a2 is embryonic lethal. Heterozygous-homozygous and homozygous-heterozygous KO combinations lead to reduced male fertility, with the het-hom combination exacerbating the phenotype of single homozygous Ptp4a2 KO.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026064 Ensembl Gene Model | MGI Sequence Detail 9469 C57BL/6J ±  kb
transcript ENSMUST00000232841 Ensembl | MGI Sequence Detail 4236 Not Applicable  
polypeptide ENSMUSP00000156862 Ensembl | MGI Sequence Detail 173 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    cDNA 28
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2138452, MGI:2138775
References
more
  • Summaries
    All 46
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:44686 Diamond RH, et al., PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth. Mol Cell Biol. 1994 Jun;14(6):3752-62
  • Latest
    J:254330 Sacchetti C, et al., PTP4A1 promotes TGFbeta signaling and fibrosis in systemic sclerosis. Nat Commun. 2017 Oct 20;8(1):1060

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/13/2018
MGI 6.13
The Jackson Laboratory