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Slc13a2 Gene Detail
Summary
  • Symbol
    Slc13a2
  • Name
    solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
  • Synonyms
    mNaDC-1, Nadc1, sodium/dicarboxylate co-transporter
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276558
    NCBI Gene: 20500
  • Gene Overview
    MyGene.info: SLC13A2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:78397087-78422217 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25131 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SLC13A2, solute carrier family 13 member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC13A2, solute carrier family 13 member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NaCT, NaDC-1, NADC1, SDCT1
  • Links
    NCBI Gene ID: 9058
    neXtProt AC: NX_Q13183
    UniProt: Q13183

  • Chr Location
    17q11.2; chr17:28473358-28497781 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased Kreb cycle intermediates in the urine but otherwise have normal kidney function and response to ischemia-reperfusion injury and caloric restriction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000000151 VEGA Gene Model | MGI Sequence Detail 25131 C57BL/6J ±  kb
    transcript OTTMUST00000000474 VEGA | MGI Sequence Detail 2412 Not Applicable  
    polypeptide OTTMUSP00000000208 VEGA | MGI Sequence Detail 586 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      119 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 1
      cDNA 30
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 14
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory