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Slc13a2 Gene Detail
Summary
  • Symbol
    Slc13a2
  • Name
    solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
  • Synonyms
    mNaDC-1, Nadc1, sodium/dicarboxylate co-transporter
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276558
    NCBI Gene: 20500
  • Gene Overview
    MyGene.info: SLC13A2
Location & Maps
more
  • Sequence Map
    Chr11:78397087-78422217 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25131 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SLC13A2, solute carrier family 13 member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC13A2, solute carrier family 13 member 2
    Orthology source: HomoloGene
  • Synonyms
    NaCT, NaDC-1, NADC1, SDCT1
  • Links
    NCBI Gene ID: 9058
    neXtProt AC: NX_Q13183

  • Chr Location
    17p13.2; chr17:28473357-28497781 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Targeted
    3
  • Genomic Mutations
    2 involving Slc13a2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit increased Kreb cycle intermediates in the urine but otherwise have normal kidney function and response to ischemia-reperfusion injury and caloric restriction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000151 VEGA Gene Model | MGI Sequence Detail 25131 C57BL/6J ±  kb
transcript OTTMUST00000000474 VEGA | MGI Sequence Detail 2412 Not Applicable  
polypeptide OTTMUSP00000000208 VEGA | MGI Sequence Detail 586 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    119 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000014934 solute carrier family 13 member 2
  • InterPro Domains
    IPR001898 Sodium/sulphate symporter
    IPR031312 Sodium/sulphate symporter, conserved site
Molecular
Reagents
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  • All nucleic 33
    Genomic 1
    cDNA 30
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:43593 Schorpp M, et al., Characterization of mouse and human nude genes. Immunogenetics. 1997;46(6):509-15
  • Latest
    J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory