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Ttc3 Gene Detail
Summary
  • Symbol
    Ttc3
  • Name
    tetratricopeptide repeat domain 3
  • Synonyms
    2610202A04Rik, D16Ium21, D16Ium21e, TPRD
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276539
    NCBI Gene: 22129
  • Gene Overview
    MyGene.info: TTC3
Location & Maps
more
  • Sequence Map
    Chr16:94370618-94522117 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      151500 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 55.18 cM, cytoband C3.3-4
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    TTC3, tetratricopeptide repeat domain 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TTC3, tetratricopeptide repeat domain 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DCRR1, RNF105, TPRDIII
  • Links
    NCBI Gene ID: 7267
    neXtProt AC: NX_P53804

  • Chr Location
    21q22.2; chr21:37073254-37203107 (+)  GRCh38.p2
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from multigenic genotypes
    26 phenotype references
  • All Mutations and Alleles
    49
  • Gene trapped
    36
  • Targeted
    9
  • Transgenic
    4
  • Genomic Mutations
    8 involving Ttc3
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    242
  • Tissues
    198
  • cDNA Data
    38
  • Literature Summary
    9
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030295 VEGA Gene Model | MGI Sequence Detail 151500 C57BL/6J ±  kb
transcript OTTMUST00000074998 VEGA | MGI Sequence Detail 7417 Not Applicable  
polypeptide OTTMUSP00000039241 VEGA | MGI Sequence Detail 1979 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1253 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    Genomic 3
    cDNA 40
    Primer pair 1
    Other 1

    Microarray probesets 9
Other
Accession IDs
less
MGD-MRK-33853, MGI:106166, MGI:1917694, MGI:2146340
References
more
  • Summaries
    All 42
    Developmental Gene Expression 9
    Diseases 3
    Gene Ontology 6
    Phenotypes 26
  • Earliest
    J:34963 Wei J, et al., Direct cDNA selection with DNA microdissected from mouse chromosome 16: isolation of novel clones and construction of a partial transcription map of the C3-C4 region. Genome Res. 1996 Aug;6(8):678-87
  • Latest
    J:233532 Scekic-Zahirovic J, et al., Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss. EMBO J. 2016 May 17;35(10):1077-97
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory