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Ttc3 Gene Detail
Summary
  • Symbol
    Ttc3
  • Name
    tetratricopeptide repeat domain 3
  • Synonyms
    2610202A04Rik, D16Ium21, D16Ium21e, TPRD
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276539
    NCBI Gene: 22129
  • Gene Overview
    MyGene.info: TTC3
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:94370620-94469222 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 55.18 cM, cytoband C3.3-4
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    751 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1276539
 protein coding gene Chr16:94370618-94522117 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023071
 protein coding gene Chr16:95607681-95711550 (+)
A/J MGP_AJ_G0023039
 protein coding gene Chr16:91108181-91207478 (+)
AKR/J MGP_AKRJ_G0023009
 protein coding gene Chr16:93905353-94007029 (+)
BALB/cJ MGP_BALBcJ_G0023041
 protein coding gene Chr16:91645147-91744287 (+)
C3H/HeJ MGP_C3HHeJ_G0022802
 protein coding gene Chr16:94420495-94520303 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023488
 protein coding gene Chr16:98654582-98759178 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020990
 protein coding gene Chr16:88970143-89071608 (+)
CAST/EiJ MGP_CASTEiJ_G0022321
 protein coding gene Chr16:95164680-95271812 (+)
CBA/J MGP_CBAJ_G0022771
 protein coding gene Chr16:102930374-103034835 (+)
DBA/2J MGP_DBA2J_G0022905
 protein coding gene Chr16:90999798-91099470 (+)
FVB/NJ MGP_FVBNJ_G0022879
 protein coding gene Chr16:90163541-90262391 (+)
LP/J MGP_LPJ_G0022975
 protein coding gene Chr16:95273974-95375351 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022900
 protein coding gene Chr16:107254914-107361710 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023506
 protein coding gene Chr16:94424801-94528517 (+)
PWK/PhJ MGP_PWKPhJ_G0022066
 protein coding gene Chr16:91267460-91368641 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021896
 protein coding gene Chr16:93970072-94070953 (+)
WSB/EiJ MGP_WSBEiJ_G0022372
 protein coding gene Chr16:94675299-94782134 (+)



Homology
more
  • Human Ortholog
    TTC3, tetratricopeptide repeat domain 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TTC3, tetratricopeptide repeat domain 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DCRR1, RNF105, TPRDIII
  • Links
    NCBI Gene ID: 7267
    neXtProt AC: NX_P53804
    UniProt: P53804

  • Chr Location
    21q22.13; chr21:37073184-37203118 (+)  GRCh38.p7
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from multigenic genotypes
    32 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    242
  • Tissues
    198
  • cDNA Data
    38
  • Literature Summary
    9
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 22129 NCBI Gene Model | MGI Sequence Detail 98603 C57BL/6J ±  kb
transcript NM_009441 RefSeq | MGI Sequence Detail 7295 Not Specified  
polypeptide O88196 UniProt | EBI | MGI Sequence Detail 1979 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    Genomic 3
    cDNA 40
    Primer pair 1
    Other 1

    Microarray probesets 9
Other
Accession IDs
less
MGD-MRK-33853, MGI:106166, MGI:1917694, MGI:2146340
References
more
  • Summaries
    All 65
    Developmental Gene Expression 9
    Diseases 3
    Gene Ontology 3
    Phenotypes 32
  • Earliest
    J:128897 Smith DJ, et al., Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2. Genomics. 1995 Jun 10;27(3):425-34
  • Latest
    J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/06/2018
MGI 6.13 		The Jackson Laboratory