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Ncoa3 Gene Detail
Summary
  • Symbol
    Ncoa3
  • Name
    nuclear receptor coactivator 3
  • Synonyms
    2010305B15Rik, AIB1, bHLHe42, KAT13B, pCIP, RAC3, Src3, TRAM-1, TRAM1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276535
    NCBI Gene: 17979
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:165834557-165915162 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 86.22 cM, cytoband H2-H4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1761 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1276535
 protein coding gene Chr2:165834545-165915162 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026899
 protein coding gene Chr2:171611913-171703641 (+)
A/J MGP_AJ_G0026865
 protein coding gene Chr2:164560675-164641979 (+)
AKR/J MGP_AKRJ_G0026838
 protein coding gene Chr2:169472959-169554303 (+)
BALB/cJ MGP_BALBcJ_G0026874
 protein coding gene Chr2:164922706-165004178 (+)
C3H/HeJ MGP_C3HHeJ_G0026618
 protein coding gene Chr2:169823199-169906297 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027322
 protein coding gene Chr2:176594374-176683213 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024694
 protein coding gene Chr2:157938444-158020917 (+)
CAST/EiJ MGP_CASTEiJ_G0026076
 protein coding gene Chr2:170257436-170342408 (+)
CBA/J MGP_CBAJ_G0026595
 protein coding gene Chr2:183040108-183141064 (+)
DBA/2J MGP_DBA2J_G0026731
 protein coding gene Chr2:163708388-163790096 (+)
FVB/NJ MGP_FVBNJ_G0026699
 protein coding gene Chr2:162179598-162260774 (+)
LP/J MGP_LPJ_G0026833
 protein coding gene Chr2:171634462-171720738 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026718
 protein coding gene Chr2:186504467-186590416 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027378
 protein coding gene Chr2:169368744-169454770 (+)
PWK/PhJ MGP_PWKPhJ_G0025811
 protein coding gene Chr2:163329717-163412087 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025613
 protein coding gene Chr2:168297423-168389236 (+)
WSB/EiJ MGP_WSBEiJ_G0026147
 protein coding gene Chr2:170265984-170353610 (+)



Homology
more
  • Human Ortholog
    NCOA3, nuclear receptor coactivator 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCOA3, nuclear receptor coactivator 3
  • Synonyms
    ACTR, AIB-1, AIB1, bHLHe42, CAGH16, CTG26, KAT13B, pCIP, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1
  • Links
    NCBI Gene ID: 8202
    UniProt: Q9Y6Q9

  • Chr Location
    20q13.12; chr20:47501887-47656877 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NCOA3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    109 phenotypes from 6 alleles in 8 genetic backgrounds
    9 phenotypes from multigenic genotypes
    1 images
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice exhibit growth defects and reduced serum IGF-1 levels and may show impaired proliferative responses to various factors, delayed mammary gland growth and puberty, reproductive dysfunction, susceptibility to endotoxin shock, altered lymphopoiesis, and protection against obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    971
  • Tissues
    184
  • cDNA Data
    20
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17979 NCBI Gene Model | MGI Sequence Detail 80606 C57BL/6J ±  kb
    transcript NM_001405160 RefSeq | MGI Sequence Detail 7744 C57BL/6  
    polypeptide O09000 UniProt | EBI | MGI Sequence Detail 1398 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000011042 nuclear receptor coactivator 3
      (term hierarchy)
    • EC
      2.3.1.48
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR017426 Nuclear receptor coactivator
      IPR032565 Nuclear receptor coactivator 2/3, DUF4927
      IPR010011 Nuclear receptor coactivator, DUF1518
      IPR009110 Nuclear receptor coactivator, interlocking
      IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
      IPR037077 Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily
      IPR014935 Nuclear receptor coactivator, receptor-binding domain
      IPR000014 PAS domain
      IPR035965 PAS domain superfamily
      IPR013767 PAS fold
    • GlyGen
      O09000 6 sites, 1 O-linked glycan (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 1
      cDNA 20
      Primer pair 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1919360, MGI:2139344
    References
    more
    • Summaries
      All 139
      Developmental Gene Expression 16
      Gene Ontology 20
      Phenotypes 63
    • Earliest
      J:42181 Torchia J, et al., The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function [see comments]. Nature. 1997 Jun 12;387(6634):677-84
    • Latest
      J:361157 Xie Y, et al., Deficiency of Nuclear Receptor Coactivator 3 Aggravates Diabetic Kidney Disease by Impairing Podocyte Autophagy. Adv Sci (Weinh). 2024 May;11(19):e2308378
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory