Ncoa3 MGI Mouse Gene Detail - MGI:1276535 - nuclear receptor coactivator 3

Symbol

Ncoa3
Name

nuclear receptor coactivator 3
Synonyms

2010305B15Rik, AIB1, bHLHe42, KAT13B, pCIP, RAC3, Src3, TRAM1, TRAM-1

Feature Type

protein coding gene
IDs

MGI:1276535
NCBI Gene: 17979
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr2:165834557-165915162 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 86.22 cM, cytoband H2-H4
Mapping Data

3 experiments

SNPs within 2kb

251 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1276535	protein coding gene	Chr2:165834556-165915162 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026899	protein coding gene	Chr2:171611913-171703641 (+)
A/J	MGP_AJ_G0026865	protein coding gene	Chr2:164560675-164641979 (+)
AKR/J	MGP_AKRJ_G0026838	protein coding gene	Chr2:169472959-169554303 (+)
BALB/cJ	MGP_BALBcJ_G0026874	protein coding gene	Chr2:164922706-165004178 (+)
C3H/HeJ	MGP_C3HHeJ_G0026618	protein coding gene	Chr2:169823199-169906297 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027322	protein coding gene	Chr2:176594374-176683213 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024694	protein coding gene	Chr2:157938444-158020917 (+)
CAST/EiJ	MGP_CASTEiJ_G0026076	protein coding gene	Chr2:170257436-170342408 (+)
CBA/J	MGP_CBAJ_G0026595	protein coding gene	Chr2:183040108-183141064 (+)
DBA/2J	MGP_DBA2J_G0026731	protein coding gene	Chr2:163708388-163790096 (+)
FVB/NJ	MGP_FVBNJ_G0026699	protein coding gene	Chr2:162179598-162260774 (+)
LP/J	MGP_LPJ_G0026833	protein coding gene	Chr2:171634462-171720738 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026718	protein coding gene	Chr2:186504467-186590416 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027378	protein coding gene	Chr2:169368744-169454770 (+)
PWK/PhJ	MGP_PWKPhJ_G0025811	protein coding gene	Chr2:163329717-163412087 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025613	protein coding gene	Chr2:168297423-168389236 (+)
WSB/EiJ	MGP_WSBEiJ_G0026147	protein coding gene	Chr2:170265984-170353610 (+)

Human Ortholog

NCOA3, nuclear receptor coactivator 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NCOA3, nuclear receptor coactivator 3
Synonyms

ACTR, AIB1, AIB-1, bHLHe42, CAGH16, CTG26, KAT13B, pCIP, RAC3, SRC3, SRC-3, TNRC14, TNRC16, TRAM-1
Links

HGNC:7670

NCBI Gene ID: 8202

neXtProt AC: NX_Q9Y6Q9

UniProt: Q9Y6Q9
Chr Location

20q13.12; chr20:47501857-47656877 (+) GRCh38.p7

Alliance of Genome Resources

Ncoa3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NCOA3
Protein SuperFamily

Nuclear_receptor_coactivator
Gene Tree

Ncoa3

Diseases

1 with human NCOA3 associations

				Human Disease	Mouse Models
				obesity IDs obesity DOID:9970 EFO:0001073 ICD10CM:E66.9 ICD9CM:278.00 MESH:D009765 NCI:C159658 OMIM:601665 UMLS_CUI:C0028754

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

108 phenotypes from 6 alleles in 8 genetic backgrounds
23 phenotypes from multigenic genotypes
1 images
63 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

408
Endonuclease-mediated

1
Gene trapped

393
Targeted

13
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

236 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Nullizygous mice exhibit growth defects and reduced serum IGF-1 levels and may show impaired proliferative responses to various factors, delayed mammary gland growth and puberty, reproductive dysfunction, susceptibility to endotoxin shock, altered lymphopoiesis, and protection against obesity.

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All GO Annotations

62
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

963
Tissues

179
cDNA Data

20
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NCOA3

Xenbase ncoa3

ZFIN ncoa3

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Ncoa3 interacts with 377 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

65
RefSeq

14
UniProt

7
CCDS

CCDS38333.1, CCDS89586.1

Ensembl

ENSMUSG00000027678 (Evidence)
NCBI Gene

17979

			Length	Strain/Species	Flank
genomic	17979	NCBI Gene Model \| MGI Sequence Detail	80606	C57BL/6J	± kb
transcript	NM_001405160	RefSeq \| MGI Sequence Detail	7744	C57BL/6
polypeptide	O09000	UniProt \| EBI \| MGI Sequence Detail	1398	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000011042 nuclear receptor coactivator 3

(term hierarchy)
EC

2.3.1.48
InterPro Domains

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

IPR017426 Nuclear receptor coactivator

IPR032565 Nuclear receptor coactivator 2/3, DUF4927

IPR028818 Nuclear receptor coactivator 3

IPR010011 Nuclear receptor coactivator, DUF1518

IPR009110 Nuclear receptor coactivator, interlocking

IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking

IPR037077 Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily

IPR014935 Nuclear receptor coactivator, receptor-binding domain

IPR000014 PAS domain

IPR035965 PAS domain superfamily

IPR013767 PAS fold

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All nucleic 25

Genomic 1

cDNA 20

Primer pair 4

Microarray probesets 6

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MGI:1919360, MGI:2139344

Summaries

All 131

Developmental Gene Expression 16

Diseases 1

Gene Ontology 15

Phenotypes 63
Earliest

J:42181 Torchia J, et al., The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function [see comments]. Nature. 1997 Jun 12;387(6634):677-84
Latest

J:324899 Meng H, et al., Defining the mammalian coactivation of hepatic 12-h clock and lipid metabolism. Cell Rep. 2022 Mar 8;38(10):110491

TSS for Ncoa3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21748	Chr2:165834528-165834539 (+)	-23 bp
Tssr21749	Chr2:165834545-165834587 (+)	9 bp
Tssr21750	Chr2:165834598-165834607 (+)	46 bp
Tssr21751	Chr2:165834635-165834646 (+)	84 bp
Tssr21752	Chr2:165839308-165839330 (+)	4,762 bp
Tssr21753	Chr2:165845224-165845245 (+)	10,678 bp
Tssr21754	Chr2:165851536-165851542 (+)	16,982 bp
Tssr21755	Chr2:165854853-165854866 (+)	20,303 bp
Tssr21756	Chr2:165858169-165858174 (+)	23,615 bp
Tssr21757	Chr2:165862212-165862215 (+)	27,657 bp
Tssr21758	Chr2:165877427-165877443 (+)	42,878 bp
Tssr21759	Chr2:165901106-165901140 (+)	66,566 bp
Tssr21760	Chr2:165901232-165901248 (+)	66,683 bp
Tssr21761	Chr2:165910669-165910673 (+)	76,114 bp
Tssr21762	Chr2:165910965-165910968 (+)	76,410 bp
Tssr21763	Chr2:165914121-165914143 (+)	79,575 bp
Tssr21764	Chr2:165914467-165914468 (+)	79,911 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/22/2022 MGI 6.21