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Ncoa3
Gene Detail
Symbol

Name
ID
Ncoa3
nuclear receptor coactivator 3
MGI:1276535
Synonyms
2010305B15Rik, AIB1, bHLHe42, KAT13B, pCIP, RAC3, Src3, TRAM1, TRAM-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
86.22 cM, cytoband H2-H4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:165992636-166071470 bp, + strand
From VEGA annotation of GRCm38

  78835 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4764  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NCOA3
Protein SuperFamily: nuclear receptor coactivator
Gene Tree: Ncoa3

Human
homologs
NCOA3, nuclear receptor coactivator 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8202
neXtProt AC: NX_Q9Y6Q9

Human Synonyms: ACTR, AIB1, AIB-1, bHLHe42, CAGH16, CTG26, KAT13B, pCIP, RAC3, SRC3, SRC-3, TNRC14, TNRC16, TRAM-1

Human Chr (Location): 20q12; chr20:47501857-47656877 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(472) : Gene trapped(464) Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Nullizygous mice exhibit growth defects and reduced serum IGF-1 levels and may show impaired proliferative responses to various factors, delayed mammary gland growth and puberty, reproductive dysfunction, susceptibility to endotoxin shock, altered lymphopoiesis, and protection against obesity.
 
Phenotype Images(1)
Interactions
Ncoa3 interacts with 377 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process cellular response to estradiol stimulus, cellular response to hormone stimulus, ...
Component cytoplasm, extracellular exosome, ...
Function androgen receptor binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (240)    Tissues (166)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 193
RT-PCR 47
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA NCOA3 ; Xenbase ncoa3 ; ZFIN ncoa3    NEW 
Molecular
reagents
All nucleic(24) Genomic(1) cDNA(19) Primer pair(4)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000001163 (Evidence)
Ensembl Gene Model ENSMUSG00000027678 (Evidence)
Entrez Gene 17979 (Evidence)
DFCI TC1694868, TC1622416, TC1616696, TC1608172, TC1579066
EC 2.3.1.48
Consensus CDS Project CCDS38333.1
International Mouse Phenotyping Consortium Status Ncoa3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001163 VEGA Gene Model | MGI Sequence Detail 78835 C57BL/6J ±  kb
transcript OTTMUST00000002259 VEGA | MGI Sequence Detail 5757 Not Applicable 
polypeptide OTTMUSP00000001104 VEGA | MGI Sequence Detail 1402 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(6) UniProt(7)
Polymorphisms
SNPs within 2kb(258 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010011 Domain of unknown function DUF1518
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR017426 Nuclear receptor coactivator
InterPro IPR009110 Nuclear receptor coactivator, interlocking
InterPro IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
InterPro IPR008955 Nuclear receptor coactivator Src-1
InterPro IPR000014 PAS domain
InterPro IPR013767 PAS fold
InterPro IPR014710 RmlC-like jelly roll fold
InterPro IPR014935 Steroid receptor coactivator
Protein Ontology PR:000011042 nuclear receptor coactivator 3
References
(Earliest) J:42181 Torchia J, et al., The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function [see comments]. Nature. 1997 Jun 12;387(6634):677-84
(Latest) J:210725 Stashi E, et al., Research resource: loss of the steroid receptor coactivators confers neurobehavioral consequences. Mol Endocrinol. 2013 Oct;27(10):1776-87
All references(95)
Other
accession IDs
MGI:1919360, MGI:2139344

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory