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Ncoa3 Gene Detail
Summary
  • Symbol
    Ncoa3
  • Name
    nuclear receptor coactivator 3
  • Synonyms
    2010305B15Rik, AIB1, bHLHe42, KAT13B, pCIP, RAC3, Src3, TRAM1, TRAM-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276535
    NCBI Gene: 17979
  • Gene Overview
    MyGene.info: NCOA3
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr2:165992636-166071470 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      78835 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 86.22 cM, cytoband H2-H4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NCOA3, nuclear receptor coactivator 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NCOA3, nuclear receptor coactivator 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACTR, AIB1, AIB-1, bHLHe42, CAGH16, CTG26, KAT13B, pCIP, RAC3, SRC3, SRC-3, TNRC14, TNRC16, TRAM-1
  • Links
    NCBI Gene ID: 8202
    neXtProt AC: NX_Q9Y6Q9
    UniProt: Q9Y6Q9

  • Chr Location
    20q13.12; chr20:47501857-47656877 (+)  GRCh38.p7
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    108 phenotypes from 6 alleles in 8 genetic backgrounds
    23 phenotypes from multigenic genotypes
    1 images
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice exhibit growth defects and reduced serum IGF-1 levels and may show impaired proliferative responses to various factors, delayed mammary gland growth and puberty, reproductive dysfunction, susceptibility to endotoxin shock, altered lymphopoiesis, and protection against obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    240
  • Tissues
    166
  • cDNA Data
    19
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000001163 VEGA Gene Model | MGI Sequence Detail 78835 C57BL/6J ±  kb
    transcript OTTMUST00000002259 VEGA | MGI Sequence Detail 5757 Not Applicable  
    polypeptide OTTMUSP00000001104 VEGA | MGI Sequence Detail 1402 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      251 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • EC
      2.3.1.48
    • InterPro Domains
      IPR010011 Domain of unknown function DUF1518
      IPR032565 Domain of unknown function DUF4927
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR017426 Nuclear receptor coactivator
      IPR028818 Nuclear receptor coactivator 3
      IPR009110 Nuclear receptor coactivator, interlocking
      IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
      IPR037077 Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily
      IPR014935 Nuclear receptor coactivator, receptor-binding domain
      IPR000014 PAS domain
      IPR035965 PAS domain superfamily
      IPR013767 PAS fold
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 1
      cDNA 19
      Primer pair 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1919360, MGI:2139344
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 15
      Phenotypes 49
    • Earliest
      J:42181 Torchia J, et al., The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function [see comments]. Nature. 1997 Jun 12;387(6634):677-84
    • Latest
      J:247655 Chen W, et al., Steroid Receptor Coactivator 3 Contributes to Host Defense against Enteric Bacteria by Recruiting Neutrophils via Upregulation of CXCL2 Expression. J Immunol. 2017 Feb 15;198(4):1606-1615
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory