Ncoa3
Gene Detail

Symbol Name ID

Ncoa3 nuclear receptor coactivator 3 MGI:1276535

Synonyms

2010305B15Rik, AIB1, bHLHe42, KAT13B, pCIP, RAC3, Src3, TRAM1, TRAM-1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

86.22 cM, cytoband H2-H4
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:165992636-166071470 bp, + strand From VEGA annotation of GRCm38   78835 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4764  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: nuclear receptor coactivator
Gene Tree: Ncoa3

Human homologs

Human Homolog		NCOA3, nuclear receptor coactivator 3
NCBI Gene ID		8202
neXtProt AC		NX_Q9Y6Q9
Human Synonyms		ACTR, AIB1, AIB-1, bHLHe42, CAGH16, CTG26, KAT13B, pCIP, RAC3, SRC3, SRC-3, TNRC14, TNRC16, TRAM-1
Human Chr (Location)		20q12; chr20:47501857-47656877 (+)  GRCh38

Alleles and phenotypes

All alleles(472) : Gene trapped(464) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 

Nullizygous mice exhibit growth defects and reduced serum IGF-1 levels and may show impaired proliferative responses to various factors, delayed mammary gland growth and puberty, reproductive dysfunction, susceptibility to endotoxin shock, altered lymphopoiesis, and protection against obesity.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (44 annotations)

Process	developmental growth, histone acetylation, ...
Component	cytoplasm, Golgi apparatus, ...
Function	androgen receptor binding, chromatin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)

Data Summary: Results (247)    Tissues (169)    Images (15)
Theiler Stages: 2, 3, 4, 5, 17, 21, 22, 23, 27, 28

Assay Type	Results
RNA in situ	193
RT-PCR	54

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(1) cDNA(19) Primer pair(4)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000001163 (Evidence)
Ensembl Gene Model	ENSMUSG00000027678 (Evidence)
Entrez Gene	17979 (Evidence)
DFCI	TC1579066, TC1608172, TC1616696, TC1622416, TC1694868
EC	2.3.1.48
Consensus CDS Project	CCDS38333.1
International Mouse Knockout Project Status	Ncoa3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001163	VEGA Gene Model | MGI Sequence Detail	78835	C57BL/6J
transcript	OTTMUST00000002259	VEGA | MGI Sequence Detail	5757	Not Applicable
polypeptide	OTTMUSP00000001104	VEGA | MGI Sequence Detail	1402	Not Applicable

All sequences(48) RefSeq(4) UniProt(7)

Polymorphisms

SNPs within 2kb(258 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR010011	Domain of unknown function DUF1518
InterPro	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
InterPro	IPR017426	Nuclear receptor coactivator
InterPro	IPR009110	Nuclear receptor coactivator, interlocking
InterPro	IPR014920	Nuclear receptor coactivator, Ncoa-type, interlocking
InterPro	IPR008955	Nuclear receptor coactivator Src-1
InterPro	IPR000014	PAS domain
InterPro	IPR013767	PAS fold
InterPro	IPR014710	RmlC-like jelly roll fold
InterPro	IPR014935	Steroid receptor coactivator
Protein Ontology	PR:000011042	nuclear receptor coactivator 3

References

(Earliest) J:42181 Torchia J, et al., The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function [see comments]. Nature. 1997 Jun 12;387(6634):677-84
(Latest) J:199012 Tien JC, et al., The steroid receptor coactivator-3 is required for the development of castration-resistant prostate cancer. Cancer Res. 2013 Jul 1;73(13):3997-4008
All references(93)

Other accession IDs

MGI:1919360, MGI:2139344